Mesenteric Lymph Flow in Endotoxemic Guinea Pigs

Nemoto, Kayo; Sato, Hitoshi; Tanuma, Kumiko; Okamura, Tadao

doi:10.1089/lrb.2011.0006

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…The mesenteric lymphatic system is the primary 'drain pipe' of the gut and has a high exposure to invading microbes and an active role in response to microbial invasions. In both low and high concentrations, LPS can regulate lymph flow rates [57]. Vascular endothelial cells express a suite of Toll-like receptors (TLRs) that can respond to microbial components including LPS [56].…”

Section: Hyperpermeability and Microbial Dysbiosis: Its Effects On Orgamentioning

confidence: 99%

Gut Permeability, Its Interaction with Gut Microflora and Effects on Metabolic Health are Mediated by the Lymphatics System, Liver and Bile Acid

et al. 2015

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There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gut leakiness'. This review will highlight changes in intestinal permeability and how it may change gut microflora and subsequently affect metabolic health by influencing the functioning of major bodily organs/organ systems: the lymphatic system, liver and pancreas. We also discuss the likelihood that metabolic syndrome undergoes a cyclic worsening facilitated by an increase in intestinal permeability leading to gut dysbiosis, culminating in ongoing poor health leading to further exacerbated gut leakiness.

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Section: Hyperpermeability and Microbial Dysbiosis: Its Effects On Orgamentioning

confidence: 99%

Gut Permeability, Its Interaction with Gut Microflora and Effects on Metabolic Health are Mediated by the Lymphatics System, Liver and Bile Acid

et al. 2015

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“…Increased pumping function has been observed during acute intestinal challenge with the inflammatory substance fMLP [56], and during edemagenic stress [57], and has been suggested to lead to increase in lymph flow (however this parameter was not measured directly). Moreover, simultaneous measurement of lymph flow and lymphatic contractility during acute challenge with LPS showed lymph flow rapidly augmenting due to an increase in pumping activity during the first two hours of the challenge, and remaining elevated in later phase despite pumping inhibition [58, 59]. Many studies performed with the aim to dissect out the role of individual components of the inflammatory soup in lymphatic pumping modulation and classical inflammatory mediators, such as prostanoids, histamine or nitric oxide have been shown to modulate lymphatic pumping and lymph drainage (see reviews [60, 61]).…”

Section: Introductionmentioning

confidence: 99%

“…Although contractile function of lymphatic vessels is reduced and lymphatic vessels are dilated during inflammation [51-53, 58, 59]. The consequence of these changes with respect to lymph transport is not clear.…”

Section: Introductionmentioning

confidence: 99%

“…They have provided quantitative measures of bulk flow rates, but also have their caveats. Lymph flow was measured during lymphatic cannulation, where lymph was collected from the main mesenteric lymphatics draining the gut with a small glass micropipette [56, 59, 85]. While accurate, this method does not provide information on lymph flow in prenodal, afferent lymphatics as it has so far only been obtained from postnodal larger vessels.…”

Section: Introductionmentioning

confidence: 99%

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Inflammation-induced lymphangiogenesis and lymphatic dysfunction

Liao

Weid

2014

Angiogenesis

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The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphatic contractile dysfunction occur in both vascular and nodal parts of the lymphatic system during inflammation, as well as other disease processes. This review provides a critical update on the role of the lymphatic system in disease process such as chronic inflammation and cancer and examines the changes in lymphatic functions the diseases cause and the influence these changes have on the progression of the diseases.

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“…The subject matter of the NIAID-sponsored symposium has, in large measure been embraced by Lymphatic Research and Biology. [2][3][4][5][6][7][8][9][10] Our lymphatic research community is indebted to NIAID for taking a bold and innovative step in organizing the workshop whose proceedings are published in the pages of this issue. Lymphatic Research and Biology is honored to have the opportunity to disseminate this information, especially in light of the stimulus that it is likely to provide for further investigation of immune mechanisms as they relate to the lymphatic circulation.…”

mentioning

confidence: 99%