Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

Sedaghat, Katayoun; Yousefian, Zahra; Vafaei, Abbas Ali; Rashidy-Pour, Ali; Parsaei, Houman; Khaleghian, Ali; Choobdar, Sara

doi:10.1016/j.bbr.2018.08.020

Cited by 47 publications

(36 citation statements)

References 63 publications

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“…The results of the study indicate that CUMS provokes marked behavioral, neurochemical, neurohormonal, and neuroinflammation alterations in adult OVX rats with long-lasting estrogens decline. Our data are in agreement with our recent data and other findings, which indicated that longterm estrogen deprivation in female rodents subjected to a CUMS procedure results in a profound affective-like profile [54].…”

Section: Discussionsupporting

confidence: 94%

Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Koshkina¹,

Волкова²,

Fedotova³

2020

Vitamin D Deficiency

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The aim of the present study was to focus on the effects of Vitamin D 3 (VD 3) supplementation (5.0 mg/kg, s.c.) on the NF-kB/p65, 17β-estradiol (17β-E 2)/ VD 3 receptors expression in the hippocampus in the long-term ovariectomized (OVX) rats treated with low dose of 17β-E 2 (0.5 μg/rat, s.c.) submitted for the chronic unpredictable mild stress (CUMS) for 28 days. Sucrose preference (SPT), forced swimming (FST), and open-field (OFT) tests were conducted to estimate the anhedonia-/depression-like states. NF-kB/p65, 17β-E 2 /VD 3 receptors levels in the hippocampus were evaluated by ELISA and Western blot assays. The findings demonstrated that VD 3 at high dose (5.0 mg/kg, s.c.) in a combination with low dose of 17β-E 2 decreased anhedonia in the SPT and depression-like behavior in the FST of the long-term OVX rats submitted to CUMS. VD 3 (5.0 mg/kg) resulted in significant decreased levels of hippocampal NF-kB/p65 protein expression, as well as to the normalization of hippocampal 17β-E 2 /VD 3 receptors levels in long-term OVX rats treated with 17β-E 2 exposed to CUMS. In conclusion, VD 3 (5.0 mg/kg, s.c.) in a combination with low dose of 17β-E 2 had a synergic antianhedonic-and antidepressant-like effects in the adult female rats following long-term ovariectomy submitted to CUMS.

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Section: Discussionsupporting

confidence: 94%

Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Koshkina¹,

Волкова²,

Fedotova³

2020

Vitamin D Deficiency

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“…The behavioral effects of VD 3 in the long-term OVX rats with CUMS observed in the present study are in agreement with the existing literature. More specifically, VD 3 has been found to restore locomotor activity and anhedonic states in other research with rodent stress models (Camargo et al, 2018;Sedaghat et al, 2019). However, this is the first study showing the anxiolytic-like effect of VD 3 at a dose of 5.0 mg/kg in long-term OVX rats with CUMS.…”

Section: Discussionmentioning

confidence: 71%

Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

Baranenko¹,

Fedotova²,

Tol³

2019

Biocell

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The impact of various vitamin D3 (VD3) doses (1.0, 2.5, or 5 mg/kg, s.c.) in mitigating the negative consequences of chronic unpredictable mild stress (CUMS) was investigated. Adult female rats with long-term estrogen deficiency were assessed using the sucrose preference test (SPT), the elevated plus-maze (EPM), the light/dark test (LDT), and the open-field test (OFT) to measure anhedonia-like and anxiety-like behavior. The corticosterone (CS) and adrenocorticotrophic hormone (ACTH) concentrations in blood serum and the brain-derived neurotrophic factor (BDNF) expression in the hippocampus of long-term ovariectomized (OVX) rats were measured by ELISA kits and/ or western blotting. Treatment with VD3 (5.0 mg/kg), similarly to fluoxetine (10.0 mg/kg), significantly reduced the anhedonia profile in the SPT and anxiety-like behavior in the EPM and LDT, and CS and ACTH levels in blood serum.It also elevated BDNF levels in the hippocampus of long-term OVX/CUMS compared to OVX/CUMS/solvent rats.Thus, these findings suggest that VD3 (5.0 mg/kg) administration might attenuate the anxiety-like profile in longterm OVX adult rats subjected to the CUMS. This might occur via activation of the BDNF signaling pathway in the hippocampus and via restoration of CS and ACTH levels in blood serum.

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“…Other studies have demonstrated that fluoxetine reversed depression-like profiles of OVX rats in a stress depression model [52]. Moreover, preclinical findings have demonstrated that fluoxetine might restore the functional activity of the HPA and 5-HT systems, and BDNF expression in different structures of the brain, improving symptoms of depression in OVX rats with different postovariectomy intervals in both stressed and non-stressed behavioral models [52,53,58]. The results of the current study indicate that CUMS provokes marked behavioral, and neurochemical/neurohormonal alterations in adult OVX rats with longlasting estrogens decline.…”

Section: Fig 8 Vd 3 Modulates Hippocampal Bdnf Expression In Long-tmentioning

confidence: 98%

“…Before and after the initiation of the 4 weeks CUMS procedures, the experimental rats underewent the sucrose preference test (SPT) [52,53]. This test is set up as follows: Following a training trial, the rats are subjected to a 24 h deprivation of food and water.…”

Section: Sucrose Preference Testmentioning

confidence: 99%

Synergic action of Vitamin D₃ and 17β-estradiol on behavioral impairments induced by unpredictable mild stress in the adult ovariectomized female rats

Baranenko

Миронова

Fedotova

et al. 2019

Preprint

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The aim of the present study was study changes in antidepressant-like responses to Vitamin D3 (VD3) supplementation in three different doses (1.0, 2.5, and 5.0 mg/kg, s.c.) in long-term ovariectomized (OVX) rats treated with low dose of 17β-E2 (0.5 μg/rat, s.c.) during chronic unpredictable mild stress (CUMS). Sucrose preference (SPT), forced swimming (FST), and open-field (OFT) tests were administered to measure depression-like behavior. Brain-derived neurotrophic factor (BDNF), and serotonine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the hippocampus were measured by ELISA, western blotting analysis, and by using high performance liquid chromatography (HPLC), respectively.The findings demonstrated that VD3 (5.0 mg/kg, s.c.) in a combination with low dose of 17β-E2 increased sucrose consumption in the SPT and decreased depression-like in the FST of the long-term OVX rats exposed to CUMS. VD3 (5.0 mg/kg) resulted in significant elevated levels of hippocampal BDNF protein expression, as well as to the normalization of 5-HT and 5-HIAA levels in long-term OVX rats plus 17β-E2 compared to the OVX rats plus solvent or 17β-E2 submitted to CUMS. There were no significant effects of VD3 (1.0 and 2.5 mg/kg) treatment on both BDNF protein levels and 5-HT turnover in the hippocampus of the long-term OVX rats treated with 17β-E2 exposed to CUMS compared to the long-term OVX with CUMS rats plus solvent.In conclusion, VD3 (5.0 mg/kg, s.c.) in a combination with low dose of 17β-E2 had a synergic antianhedonic- and antidepressant-like effects in the adult female rats following long-term ovariectomy submitted to CUMS. This is the first study in long-term OVX female rats showing beneficial effects of VD3 on depression-like behavior that are depended on the presence/absence of stressful factors.

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Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

Cited by 47 publications

References 63 publications

Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

Synergic action of Vitamin D₃ and 17β-estradiol on behavioral impairments induced by unpredictable mild stress in the adult ovariectomized female rats

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Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

Cited by 47 publications

References 63 publications

Vitamin D3 Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Vitamin D3 Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

Synergic action of Vitamin D3 and 17β-estradiol on behavioral impairments induced by unpredictable mild stress in the adult ovariectomized female rats

Contact Info

Product

Resources

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Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Vitamin D₃ Modulates NF-kB/p65, 17β-Estradiol, and Vitamin D Receptors Expression at Estrogen Deficiency

Synergic action of Vitamin D₃ and 17β-estradiol on behavioral impairments induced by unpredictable mild stress in the adult ovariectomized female rats