Mesonephric adenocarcinoma of the vagina with a 3-year follow-up

Erşahin, Çağatay; Huang, Min Hsiung; Potkul, Ronald K.; Hammadeh, Rasheed; Salhadar, Alia

doi:10.1016/j.ygyno.2005.07.010

Cited by 24 publications

(26 citation statements)

References 9 publications

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“…Mesonephric adenocarcinomas of uterine cervix, which are presumed to arise from mesonephric hyperplasia or mesonephric remnants, are characterized by morphological diversity and an unusual appearance 6 . Diff erential diagnoses include adenoma malignum, well-diff erentiated villoglandular adenocarcinoma, endometrioid adenocarcinoma, serous adenocarcinoma, mesonephric adenocarcinoma with a sarcomatous component, clear-cell carcinoma and mesonephric hyperplasia 6,7,9 . In almost all cases reported in the literature, mesonephric hyperplasia classifi ed as diff use mesonephric hyperplasia, ductal mesonephric hyperplasia and lobular mesonephric hyperplasia was observed adjacent to mesonephric adenocarcinoma, especially lobular and diff use subtypes 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Only 16% of carcinosarcomas reported in the English literature were of mesonephric duct origin 2 . Th e typical histologic features of clear-cell cytoplasm and hobnail cell pattern, and the presence of PAS positive intraluminal secretion with PAS positive intracytoplasmic globules direct us to the diagnosis of clear-cell carcinoma 9 . Th e absence of mesonephric hyperplasia is associated with endometrioid adenocarcinoma and clear-cell carcinoma 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Our case demonstrated characteristic cytokeratin 7, vimentin and EMA positivity, high Ki-67 proliferation index (60%), negative ER, PR, CEA and PAS positive intraluminal secretion with PAS negative carcinoma cells. Recent reports showed that immunohistochemical features of mesonephric adenocarcinoma included positivity for epithelial markers including pancytokeratin, CK7, CAM5.2 and EMA 7,9 . Vimentin is positive in 70% and calretinin in 88% of cervical mesonephric adenocarcinoma, while CK20, ER, PR and CEA are usually negative 7,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Recent reports showed that immunohistochemical features of mesonephric adenocarcinoma included positivity for epithelial markers including pancytokeratin, CK7, CAM5.2 and EMA 7,9 . Vimentin is positive in 70% and calretinin in 88% of cervical mesonephric adenocarcinoma, while CK20, ER, PR and CEA are usually negative 7,9 . Th is staining profi le is crucial in the diff erential diagnosis, especially with endometrioid and other paramesonephric adenocarcinomas, with which it may be confused.…”

Section: Discussionmentioning

confidence: 99%

“…Th e expression of p53 and/or CD10 is also useful in establishing the diagnosis of mesonephric neoplasm. CD10 has been suggested as a marker for all mesonephric lesions in the female genital tract, although there are cases of CD10 negative mesonephric adenocarcinomas reported in the literature 4,6,9 . Most other benign endocervical glandular lesions are negative for CD10 4 .…”

Section: Discussionmentioning

confidence: 99%

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Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Puljiz

Danolić

Kostić

et al. 2016

ACC

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SUMMARY -Mesonephric adenocarcinoma is a rare variant of cervical adenocarcinoma. We present a case of mesonephric adenocarcinoma of endocervix with cervical and vaginal lobular mesonephric hyperplasia in a 57-year-old woman. Vaginal bleeding persisting for 12 months was the only symptom. Histopathologic fi ndings and characteristic immunophenotype are crucial for the diagnosis. Th e tumor was composed of papillary formation with a central fi brovascular stroma, villoglandular and densely compact tubular structures containing intraluminal eosinophilic secretion, and coated with one or more rows of cylindrical atypical epithelial cells. Th ere were 30 pathologic mitotic shapes found per 10 HPF. Th e tumor invaded nearly full-thickness of cervical stroma with positive lymphovascular space invasion and clear margins. Th e case demonstrated characteristic cytokeratin 7, vimentin and epithelial membrane antigen positivity and high Ki-67 proliferation index (60%). Estrogen receptors, progesterone receptors and carcinoembryonic antigen were negative. Intratubular lumen secretion was periodic acid-Schiff positive with periodic acid-Schiff negative carcinoma cells. Diff erential diagnoses include adenoma malignum, well-diff erentiated villoglandular adenocarcinoma, endometrioid adenocarcinoma, serous adenocarcinoma, mesonephric adenocarcinoma with a sarcomatous component, clear-cell carcinoma and mesonephric hyperplasia. Radical hysterectomy with bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy was performed. Th ree years after the surgery, the patient remains well. Th ere has not been any evidence of local or distant recurrence. Th ere are no specifi c recommendations for the treatment of this rare disease. It remains uncertain whether surgical approach is suffi cient or the treatment should include additional radio/chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Puljiz

Danolić

Kostić

et al. 2016

ACC

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Cysts, Non neoplastic Glandular Lesions, and Glandular Neoplasms of the Vulva and Vagina

Faruqi

2012

Pathology of the Vulva and Vagina

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Mesonephric adenocarcinoma of the vagina

et al. 2016

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BackgroundMesonephric adenocarcinoma of the vagina is an extremely rare tumor of the female genital tract, with only a few cases reported so far worldwide. Consequently, there is no established standard treatment and limited knowledge about the prognosis and biologic behavior of vaginal mesonephric adenocarcinoma.MethodsThis report documents a new case of vaginal mesonephric adenocarcinoma diagnosed in a 54-year-old woman, and analyzes this in the context of all previously published cases.ResultsMRI demonstrated that the 2.5 × 1.8 cm tumor of the vaginal wall was invading urethra and bladder. Following surgical excision, histologic analysis determined mesonephric adenocarcinoma of the vagina, stage pT2 R1. In order to avoid the mutilating extended surgery which would be required to reach R0 and considerable impairment of quality of life, adjuvant radiochemotherapy was administered with external radiation and brachytherapy, including 5 cycles of cisplatin (40 mg/m²) for radiosensitization. After 4 years of continuous oncologic follow-up, the patient is alive and clinically free of disease.ConclusionIn this case it was shown that adjuvant radiochemotherapy with radiation and brachytherapy was effective to manage the surgical R1 situation and maintain the patient’s life quality. More published cases reports are needed to gradually substantiate optimal treatment strategies.

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Mesonephric adenocarcinoma of the vagina with a 3-year follow-up

Cited by 24 publications

References 9 publications

Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Cysts, Non neoplastic Glandular Lesions, and Glandular Neoplasms of the Vulva and Vagina

Mesonephric adenocarcinoma of the vagina

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