Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Puljiz, Mario; Danolić, Damir; Kostić, Lucija; Alvir, Ilija; Tomica, Darko; Mamić, Ivica; Munivrana, Ivana Vlastelica; Puljiz, Marko; Vrdoljak, Danko Velimir; Balja, Melita Perić

doi:10.20471/acc.2016.55.02.22

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Although radical hysterectomy with or without bilateral salpingooophorectomy and pelvic lymphadenectomy is the mainstay of treatment for early-stage disease, the efficacy of chemotherapy or radiotherapy is not clear, especially in locally advanced stages. More experiences on the management of this tumor would be necessary to achieve the best strategy (11). Currently, the treatment methods are adopted from guidelines for typical cervical adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

et al. 2021

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Scan to discover onlineMesonephric adenocarcinoma of the uterine cervix is an extremely rare tumor of the female genital tract which derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding and an enlarged uterine cervix on physical examination without obvious mass lesion. She was clinically underdiagnosed with cervical myoma and mesonephric hyperplasia. After simple hysterectomy, stage IB2 mesonephric adenocarcinoma was diagnosed. Despite adjuvant chemoradiation, she presented with peritoneal and locoregional recurrence in less than a year. So, in the presence of abnormal bleeding and cervical mass, mesonephric hyperplasia in cervical biopsy specimen should be suspected for adenocarcinoma. Radical hysterectomy and complete staging with or without salpingooophorectomy is the mainstay of treatment. Despite all ambiguities, due to the small number of reported cases, the overall prognosis seems to be less favorable than conventional cervical adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

et al. 2021

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“…Нині інформація про внутрішньоутробний розвиток сечостатевої системи визначається теорією Мюллера, визнаною більшістю дослідників [14,21,33,36,40].…”

Section: результати обговоренняunclassified

Modern view on the germ and embryogenesis of the urinary organs

Bulyk¹,

Popeliuk²,

Melnyk³

et al. 2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The literature is devoted to the analysis of scientific literature for the last 10 years from the electronic databases "PubMed" and "National Library of Ukraine named after V. I. Vernadsky", which are devoted to the study of the formation and development of organs and structures of the urinary system. The consequences of perinatal morphogenesis play the most essential role in the causes and contribution to many congenital malformations (CM), stillbirths, and infant morbidity. According to the Medical and Genetic Service of the Ministry of Health of Ukraine, up to 3,000 cases of CM of various organs and systems are recorded annually among newborns in Ukraine. CM of the genitourinary system ranks 3rd in frequency, among which CM of the female genitalia is up to 6 %. These figures are somewhat subjective, as a certain percentage of pathology of the female reproductive system is detected only when a girl reaches childbearing age, which greatly complicates the choice of methods and effectiveness of treatment. The rapid development of the genitourinary system of the fetus requires morphologists to comprehensively study the patterns of morphogenesis and the development of topographic and anatomical relationships of the reproductive system and urinary tract in the early period of human ontogenesis. The problem of combining information about the structural organization of the urinary tract and genital system into a consolidated morphofunctional unit is one of the cardinal problems of perinatal urology. The final formation of the urogenital organs is as follows. The initial kidneys' replacement with the permanent ones, metanephros, begins to form, from the same nephrogenic cord that gave rise to the primary kidney. The proper permanent renal parenchyma develops from the nephrogenic cord (renal tubuli). From the 3rd month, the permanent kidneys replace the mesonephros as the excretory organs already function. Thus, the embryonic development of the genitals is closely related to the development of the urinary tract and kidneys. Therefore, the CM of these two systems often occurs together. Active introduction of perinatal prophylaxis of urogenital organs requires modern approaches and methods of examination of intrauterine life. Therefore, the complex of embryotopographic studies attains special significance, having combined the consideration of organically critical periods of development with the understanding of the peculiarities of the spatial relationships of organs and structures of the genitourinary system.

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“…Mesonephric adenocarcinoma (MNAC) is a rare carcinoma that originates from mesonephric remnant of the female genital tract [1][2][3] , and are predominantly located on the lateral walls of the cervix and vagina [4] . Of the cases reported to date, the vast majority of MNAC are from uterine cervix [1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] ., , comprising<1% of all carcinomas at this site [20] , several cases of MNAC are from ovary [21][22][23][24] , and rare cases are from vagina [4,7,[25][26][27][28][29] and uterine corpus [4,11,21,[30][31][32][33][34][35][36][37][38][39][40]…”

Section: Introductionmentioning

confidence: 99%

Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

Hu¹,

Xu²,

Deng³

et al. 2020

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Abstract Background Mesonephric adenocarcinoma (MNAC) is a rare carcinoma which arises from the mesonephric remnant of the gynecologic tract. It mainly occurs in the uterine cervix, barely locates in the uterine corpus, ovarian and vagina. To date, only a few cases of MNAC arising from of the uterine body (UB-MNAC) have been reported, and the clinicopathologic and molecular characteristics of UB-MNAC remain limited. A recent report suggested that series of UB-MNAC should be defined as Mesonephric-like adenocarcinoma carcinomas (MLAC), for they exhibited the classic morphologic features and immunophenotype of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric remnants. Thus, the histogenesis of UB-MNAC is not yet clear, they may originate in Müllerian tissue and exhibits the mesonephric differentiation phenotype, or arise from the mesonephric remnants in the uterine wall.Case presentation To better understand the histogenesis of UB-MNAC, we presented three UB-MNAC cases from west china second university hospital, which exhibited typical morphologic, histologic as well as the immunohistochemical characteristics of MNAC. Notably, among the three cases, two cases arising from the myometrium layer of the uterine corpus found mesonephric remnants around the tumor. By reviewing the published UB-MNAC and UB-MLAC, we found that to our knowledge ,it is the first time finding mesonephric remnants around the MNAC cells in the reported literature, except one case that found mesonephric remnants in the cervix, and the tumors of the three cases were all arising from the myometrium layer, without endometrium involved. Then we compared the clinical characteristics of the UB-MNAC cases arising from the myometrium and endometrium, and the results showed that the two subgroups had most in common in the clinical characteristics except the myometrium subgroup had a higher elevated CA125 level, and this result was in consistent with the Kaplan-Meier survival analysis, which indicated that the myometrium subgroup had a poorer prognosis than the endometrium group. But this need more data and further study such as the molecular analysis.Conclusion Though the pathogenesis of MLAC or MNAC of the uterine corpus is still under debate, according to our cases and the published literatures, We hypothesize two different pathways involved: the MNAC arising from the myometrium not affecting the endometrium may directly develop from the mesonephric remnant, the one occurred in the endometrium may not real mesonephric adenocarcinoma, but more likely arising from mesonephric transformation of Müllerian adenocarcinoma, and is better referred as MLAC. Besides, the two kinds of adenocarcinomas may have different clinical prognosis, while the MNAC arising from the myometrium may have a poorer prognosis than the MLAC originating from the endometrium, although they have identical morphologic and histologic characteristics.

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Mesonephric Adenocarcinoma of Endocervix With Lobular Mesonephric Hyperplasia: Case Report

Cited by 6 publications

References 16 publications

Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

Modern view on the germ and embryogenesis of the urinary organs

Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

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