Mesoporous bioglass capsule composite injectable hydrogels with antibacterial and vascularization promotion properties for chronic wound repair

Abstract

MBG@PDA composite hydrogels repair chronic wounds by establishing a microenvironment for angiogenesis and inhibiting wound infection.

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

“…The regeneration of capillary system is an important factor in the rapid healing of skin tissue. 17,42,46 The regeneration of capillaries can improve the function of cells under hypoxic condition and improve the feeding condition of the whole traumatic tissue. 44,47 Based on this, this study prepared mesoporous bioglass particles with multi-channel pore structure and rapid vascularization function, which could recruit cells during the wound healing process, accelerate the angiogenesis process and promote wound repair (Fig.…”

“…Bioactive glass (bioglass), originally developed and extensively used for bone repair, [13][14][15] has demonstrated a positive role in wound healing in recent years. 16,17 A multitude of research studies have demonstrated that bioglass holds promise as a wound healing promoter due to its remarkable potential to significantly enhance and activate the cellular behaviors of inflammatory cells, fibroblasts, and endothelial cells, as well as their intricate interplay. 17,18 Human umbilical vein endothelial cells (HUVECs) and fibroblasts are the main types of cells involved in wound healing.…”

“…16,17 A multitude of research studies have demonstrated that bioglass holds promise as a wound healing promoter due to its remarkable potential to significantly enhance and activate the cellular behaviors of inflammatory cells, fibroblasts, and endothelial cells, as well as their intricate interplay. 17,18 Human umbilical vein endothelial cells (HUVECs) and fibroblasts are the main types of cells involved in wound healing. Studies have demonstrated that bioglass can regulate endothelial cell behavior, stimulate its mitotic response, and promote angiogenesis to improve wound healing.…”

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

“…The Stöber methodology enables manipulation of particle shape and morphology using catalysts. The precursors or ions usually incorporated during the hydrolysis and condensation reactions differentiate between silica-only nanoparticles and sol–gel BGs, with NH 4 OH playing a key role as a solvent. ,, However, adding organic compounds and metal ions affects hydrolysis–condensation reactions, resulting in undesirable morphological changes. , Careful control of experimental conditions is needed (e.g., TEOS/water ratio, reaction pH, precursor types, and concentration) to avoid agglomeration and ensure shape, size, regularity and homogeneity is retained as this directly impacts morphology and bioactivity. ,,, Individual, homogeneous, mesoporous Si-based particles of controllable size form under basic conditions. , Under acidic conditions, Si-based particles aggregate and form a 3D-gelled structure as condensation reactions proceed. , Surfactants or polymers are commonly used as templating agents, usually during the hydrolysis and condensation steps, to positively manipulate the morphological characteristics of sol–gel-derived BG morphology. ,,− For example, the surfactant cetyltrimethylammonium bromide (CTAB) enhances mesoporosity, surface area, pore volume, and particle shape of BG formulations during micelle-BG formation (discussed further in section ). ,,,,− However, CTAB and metal ions are cationic and interact with each other, decreasing mesoporosity and/or pore volume. ,, These challenges motivated investigation of additive manufacturing style synthesis techniques, although they are not commonly utilized.…”

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

“…After integration, the composite hydrogels have excellent wound closure effects, boosted reactive oxygen species-scavenging activity, and significant angiogenesis ability [ 139 ]. They also can obtain better organized epidermal and dermal layers in full-thickness skin wounds in in vivo wound healing studies [ 140 ] and realize the integration of angiogenesis and infection inhibition [ 50 ].…”