Mesoporous carbon‑manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy

Li, Xian; Feng, Xiaoqiang; Sun, Changshan; Liu, Yixuan; Zhao, Qinfu; Wang, Siling

doi:10.1016/j.jconrel.2019.12.042

Cited by 51 publications

(21 citation statements)

References 43 publications

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“…The designed stimuli-responsive systems can be delivered to diseased sites and realize on-demand drug release to improve therapeutic effects and hinder premature leakage-induced side effects. All internal and external stimuli, such as redox potential [2], pH [1], enzymes [3], and temperature and light [4,5], have been used to design stimuli-responsive DDSs. Among these stimuli, enzymes, as internal stimuli, have gained wide attention due to their distinct concentrations in different tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

et al. 2020

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An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS-N=N-CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in the hollow cavity and mesopores of HMSS with the high loading amount of 35.2%. In vitro drug release proved that HMSS-N=N-CS/DOX performed enzyme-responsive drug release. The grafted CS could increase the biocompatibility and stability and reduce the protein adsorption on HMSS. Gastrointestinal mucosa irritation and cell cytotoxicity results indicated the good biocompatibility of HMSS and HMSS-N=N-CS. Cellular uptake results indicated that the uptake of DOX was obviously increased after HMSS-N=N-CS/DOX was preincubated with a colonic enzyme mixture. HMSS-N=N-CS/DOX incubated with colon enzymes showed increased cytotoxicity, and its IC 50 value was three times lower than that of HMSS-N=N-CS/DOX group without colon enzymes. The present work lays the foundation for subsequent research on mesoporous carriers for oral colon-specific drug delivery.

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Section: Introductionmentioning

confidence: 99%

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

et al. 2020

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“…[ 16 − 18 ] Typically, PTT method involves a photoabsorber to convert near infrared (NIR) light energy into the heat at local region and the resulted temperature increase leads to the tumor ablation because of the specific slowing down of blood flow velocity. [ 19 ] A lot of important materials, including transition metal dichalcogenides, [ 20 ] gold nanoparticles, [ 21 ] carbon‐based materials, [ 22 ] organic conjugated molecules, [ 23 ] polymers, [ 24 ] and other NIR absorbing materials, have been explored for this purpose. [ 25,26 ] Meanwhile, various image‐guided PTT composites have been developed recently.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Polymer Nanocomposites Integrating Magnetic Polyoxomolybdates for Enhanced MRI and On‐Site Activated Photothermal Properties

Zhou

Wan

Kong

et al. 2020

Macromol. Rapid Commun.

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This work reports the ionic composition of a PEGylated and chemically crosslinked polyethyleneimine with a gadolinium‐coordinated polyoxomolybdate cluster, K17[Gd(P2Mo17O61)2], via electrostatic interaction. The prepared composites form nanoobjects with an average size of ≈27 nm at dried state and maintain structural stability in aqueous solution. While the biocompatibility on HeLa cells is demonstrated, the polymer‐shielded multifunctional nanoplatform shows both the combined magnetic resonance imaging and redox‐triggered photothermal conversion effect. As a contrast agent, the T1‐weighed relaxivity reaches up to 22.77 mm−1 s−1. The photothermal conversion of the prepared composites can be aroused by yielding a broad near infrared (NIR) adsorption through on‐site reduction of the glutathione that is enriched in the tumor environment. The high efficiency ≈61.0% under the irradiation of 808 nm NIR laser illustrates a distinct treatment capability according to cell counting Kit‐8 assay while the obvious inhibition for the growth of tumor cells is observed.

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“…68 In another study, US imaging was combined with MRI for cancer imaging using some manganese oxide-based NPs. 69 Although manganese oxide nanosheets 70 and mesoporous NPs 71 have been previously applied for PTT, hollow MnO 2 NPs have only recently been used. For the first time, Zeng et al fabricated polydopamine (PDA)-coated photosensitiser chlorin e6-loaded hollow MnO 2 NPs for photodynamic and photothermal synergistic breast cancer therapy.…”

Section: Dovepressmentioning

confidence: 99%

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Chen¹,

Wang²,

Shen³

2021

IJN

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Nanotechnology has prompted the development of hollow inorganic nanomedicine. These medicines are now widely investigated as photothermal-based therapies for various diseases due to their high loading capacity, tuneable wavelength, relatively small size and low density. We begin this review with a brief introduction, followed by a summary of the development of imaging-guided photothermal therapy (PTT) for cancer treatment during the last three years (from 2017 to 2020). We then introduce the antibacterial effects of these medicines on some bacterial infections, in which the pathogenic bacteria can be killed by mild photothermal effects, ions and antibiotic release. Other diseases can also be treated using hollow inorganic photothermal agents. Specifically, we discuss the use of PTT for treating Alzheimer's disease, obesity and endometriosis. Finally, we share our perspectives on the current challenges and future prospects of using hollow inorganic materials in clinical PTT for various diseases.

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Mesoporous carbon‑manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy

Cited by 51 publications

References 43 publications

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Biocompatible Polymer Nanocomposites Integrating Magnetic Polyoxomolybdates for Enhanced MRI and On‐Site Activated Photothermal Properties

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

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