Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Abstract

Photothermal therapy (PTT) is proved to be an efficient manner for superficial tumor therapy in preclinical studying. The tumor suppression of chemotherapy can be enhanced by combining with PTT. In this study, we reported a mesoporous magnetic gold “nanoclusters” (MMGNCs) structure as theranostic carrier for chemo-photothermal co-therapy. MMGNCs were successfully prepared and they exhibited efficient photo-thermal effect for PTT. The mesoporous structure provided MMGNCs with high drug loading capacity. By in vitro cytotoxicity testing, we revealed that the combination of PTT and chemotherapy could cause more damage than chemotherapy or PTT did alone. By topically targeting mediated by the extra-magnetic field (MF), MMGNCs can be targeted to the tumor site efficiently. In vivo chemo-photothermal co-therapy of 4T1 breast cancer, under the combinational treatments of chemo-photothermal co-therapy and extra-MF targeting, the tumor growth has been efficiently inhibited, and the pulmonary and mediastinal metastasis have also been prevented. The survival of the cancer bearing mice was prolonged. The bio-imaging applications of this system and the mechanism of the metastasis prevention are ongoing.

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

“…The time of incubation for cell localization was selected as 6, 24, and 48 hours. Cell viability of each well was assessed by applying MTT Assay [30,31].…”

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

“…24,25 Due to its good biosecurity, IR820 was employed as the photothermal agent in this study. 26,27 To further improve the theranostic efficiency and provide a way to image the pathological characteristics of tumors, it is necessary to develop a more effective theranostic agent to sense subtle pathological changes. The lipid-polymer hybrid nanoparticles, which have various advantages of polymeric nanoparticles and liposomes, have become a robust delivery platform with properties such as excellent stability, tunability, high drug encapsulation, and sustained drug release.…”

Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line

“…Gold nanoparticles are excellent photoabsorbers and have been extensively utilized in PTT protocols in the form of nanosized spheres, rods, and shells owing to their excellent optical properties such as very high photothermal conversion efficiencies, and optimization of their surface plasmon resonance to deep tissue penetrating red or near-infrared wavelengths. 18,26 For instance, chemotherapeutic drugs such as doxorubicin (DOX), 27,28 paclitaxel, [29][30][31][32] fluorouracil 33 and CisPt 34 have been combined with gold-based nanostructures for the treatment of various cancers. The preparation of drug-containing GNP formulations is not always straightforward and often functional limitations are encountered that hamper their clinical potential, such as: (1) poor colloidal stability (leading to drug leakage, or premature disassembly in the bloodstream), (2) low drug loading per particle volume/mass, and (3) use of unsuitable chemicals for in vitro/vivo application (for example, the use of cetyltrimethylammonium bromide in the preparation of gold nanorods 35 ).…”