Mesoporous silica material TUD-1 as a drug delivery system

Heikkilä, Teemu; Salonen, Jarno; Tuura, Jaani; Hamdy, Mohamed S.; Mul, Guido; Kumar, Narendra; Salmi, Tapio; MURZIN, D; La, Laitinen; Kaukonen, Ann Marie

doi:10.1016/j.ijpharm.2006.09.019

Cited by 208 publications

(90 citation statements)

References 24 publications

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“…[27], PLGA-SiO2 (Poly-Lactic-co-Glycolic Acid) [28], SBA-16 [29] or TDU-1 (Technical Delft University) [30]. …”

Section: Silica Based Ordered Mesoporous Materials To Host Drugsmentioning

confidence: 99%

Drug release from ordered mesoporous silicas

Doadrio¹,

Salinas²,

Sánchez-Montero³

et al. 2015

CPD

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The state of the art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for each drug, are comprehensively listed. Next, the factors influencing the release of drugs from SMMs and the strategies used to control the drug delivery, specially the chemical functionalization of the silica surface, are discussed. In addition, how all these factors were gathered in a kinetic equation that describes the drug release from the mesoporous matrixes is explained. The new application of molecular modeling and docking in the investigation of the drug delivery mechanisms from SMMs is also presented. Finally, the new approaches under investigation in this field are mentioned including the design of smart stimuli-responsive materials and other recent proposals for a future investigation.. 3

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“…[27], PLGA-SiO2 (Poly-Lactic-co-Glycolic Acid) [28], SBA-16 [29] or TDU-1 (Technical Delft University) [30]. …”

Section: Silica Based Ordered Mesoporous Materials To Host Drugsmentioning

confidence: 99%

Drug release from ordered mesoporous silicas

Doadrio¹,

Salinas²,

Sánchez-Montero³

et al. 2015

CPD

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“…[19][20][21][22] Among these mesoporous silica, Mobil Composition of Matter (MCM)-41 and Santa Barbara Amorphous (SBA)-15 , with a two dimensionally ordered hexagonal arrangement of cylindrical pores of uniform size (typically 2-10 nm) disposed parallel to each other ( Figure 1A), are probably the most investigated materials. [23][24][25] In contrast to mesoporous materials templated by surfactant micelles, three dimensionally ordered macroporous (3DOM) materials with pore sizes in the sub-micrometer range are generally templated by colloidal crystals, allowing the introduction of uniform spherical voids with controlled size, typically hundreds of nanometers in diameter 26 ( Figure 1B). The low specific surface areas, relative to mesoporous materials, combined with the three dimensionally interconnected pore networks, allowed ready accessibility to guest molecules and enhanced mass transport.…”

Section: Wang Et Almentioning

confidence: 99%

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

Wang¹,

Zhao²,

Hu³

et al. 2013

IJN

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“…Four of the most common types of mesoporous materials (MCM-41, SBA-15, TUD-1, and carbonized PSi) were recently evaluated for their ability to carry and deliver ibuprofen (Heikkilä et al 2007 ) . Of the four types tested utilizing the solvent-loading method, SBA-15 provided the highest drug load at over 50% (w/w), primarily due to its high pore volume.…”

Section: Recent Advances In the Use Of Mesoporous Silicamentioning

confidence: 99%

Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

Hughey¹,

McGinity²

2011

Formulating Poorly Water Soluble Drugs

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The need for novel formulation and process-based techniques to enhance aqueous solubility has increased substantially in recent years. This is primarily due to the limitations of traditional techniques such as physical and chemical stability of the drug substance or the need for toxic solvents that some techniques require. Alternative solubility-enhancement techniques have emerged in recent years to mitigate issues such as these. The purpose of this chapter is to describe emerging technologies for solubility enhancement, allowing the reader to gain an understanding of their utility.

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Mesoporous silica material TUD-1 as a drug delivery system

Cited by 208 publications

References 24 publications

Drug release from ordered mesoporous silicas

Drug release from ordered mesoporous silicas

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

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