Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body

Lee, Sang Bong; Kim, Hye Lan; Jeong, Hwan-Jeong; Lim, Sungjoon; Sohn, Myung‐Hee; Kim, Dong Wook

doi:10.1002/ange.201304026

Cited by 46 publications

(38 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lee et al developed an efficient 18 F-labeled aza-dibenzocyclooctynes (DBCO)-substituted MSN pretargeting for PET imaging used in animal tumor models. 33 A DBCO-based PEGylated MSN (DBCO-PEG-MSNs) was first designed to have a size of 100-150 nm in order to be accumulated in tumor site via Enhanced Permeability and Retention (EPR) effect. Then a bioorthogonal strain-promoted alkyne azide cycloaddition (SPAAC) reaction of DBCO-PEG-MSNs was obtained.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

Yang

Bao

Peng

2017

Frontiers in Nanobiomedical Research

View full text Add to dashboard Cite

Positron Emission Tomography (PET) is one of the most sensitive imaging techniques and has been widely used in tumor diagnosis. It can provide a noninvasive and regional estimation of a specific organ with its biochemical processes by introducing a radioactive isotope labeled molecule. Radiolabeled nanoparticles, which have unique characteristics such as large surface area, multifunctionality and long circulation, show great potential in molecular imaging. In this article, we describe the advances in the development of nanoparticle-based tumor PET imaging. Besides the types of radiolabeled nanoparticles (iron-oxide nanoparticles, quantum dots, upconversion nanoparticles (UCNPs), mesoporous silica nanoparticles (MSNs)), the radionuclides, targeting strategies and multimodality imaging are also mentioned.

show abstract

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

Yang

Bao

Peng

2017

Frontiers in Nanobiomedical Research

View full text Add to dashboard Cite

show abstract

“…For example, the pore surface is commonly modified with functionalities which help to control drug loading and the rate of drug release (19). The outer surface is most often used for modification with moieties that aid in increasing colloidal stability, improving biocompatibility (20)(21)(22), and achieving targeting of the particles (21,23,24). Importantly, particle shape (morphology) can be altered without changing the overall pore structure.…”

Section: Chemistry-synthesis and Surface Chemistrymentioning

confidence: 99%

The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal

et al. 2014

View full text Add to dashboard Cite

Abstract. Mesoporous silica nanoparticles (MSNs) have been proposed as drug delivery devices for approximately 15 years. The history of in vitro studies has been promising, demonstrating that MSNs have the capability for stimulus-responsive controlled release, good cellular uptake, cell specific targeting, and the ability to carry a variety of cargoes from hydrophobic drug molecules to imaging agents. However, the translation of the in vitro findings to in vivo conditions has been slow. Herein, we review the current state-of-the-art in the use of MSN for systemic drug delivery in vivo and provide critical insight into the future of MSNs as systemic drug delivery devices and directions that should be undertaken to improve their practicality.

show abstract

“…Mesoporous silica nanoparticles (MSNs) have recently attracted considerable attention in the biomedical field as an excellent candidate for the development of a therapeutic drug delivery system and a carrier for diagnosis. [8][9][10][11][12][13][14] MSNs have several attractive features that make them an excellent drug delivery system, including their large surface area, large pore volume, tailorable pore size, tunable pore diameter, controllable particle size and shape, dual-functional surfaces, and uniform porosity. These characteristics make them suitable for store pharmaceutical drugs and prevent their premature release and degradation before they reach their designated target.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of mesoporous silica nanoparticles in human embryonic kidney 293 cells

Zhang

Zheng

et al. 2015

Drug Testing and Analysis

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) have been widely evaluated for their potential use as carriers for cancer diagnosis and therapy. Understanding the toxicity of MSNs is crucial to their biomedical applications. Although several groups have reported the cytotoxicity of MSNs, the genotoxicity (inducing genetic aberrations) of MSNs in normal human cells has not been extensively investigated. Gene amplification and mutation may initiate and promote carcinogenesis, and changes in mRNA expression can affect normal human physical functions. In this study, human embryonic kidney 293 (HEK293) cells were treated overnight with MSNs at a concentration of 120 µg/mL. The cells were assayed with fluorescent in situ hybridization to check for chromosome changes and gene amplification. Mutations in the epidermal growth factor receptor 1 (EGFR1) and KRAS genes were checked with DNA sequencing. The effects of MSNs on mRNA expression were investigated with an Agilent human mRNA microarray. No chromosomal alterations or gene mutations in EGFR or KRAS were observed in the control HEK293 cells or HEK293 cells exposed to MSNs. The microarray analysis showed that MSNs significantly altered gene expression. The expression of 579 genes was upregulated and that of 1263 genes was downregulated in HEK293 cells treated with MSNs compared with the control HEK293 cells. Our findings suggest that exposure to MSNs is genotoxic to normal human cells, leading to changes in the expression of some genes. This genotoxicity may cause cellular dysfunction and certain benign diseases. We have not shown that MSN exposure induces serious genotoxicity involving carcinogenesis.

show abstract

Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body

Cited by 46 publications

References 59 publications

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal

Genotoxicity of mesoporous silica nanoparticles in human embryonic kidney 293 cells

Contact Info

Product

Resources

About