Mesoporous Silica Nanoparticles Sebagai Drug Carrier pada Aplikasi Controlled Drug Delivery System

Abstract

There are many DDS (Drug Delivery System) methods that can be used in this decade. The DDS method with nanotechnology is also increasingly in demand because it can be a controlled DDS (CDDS). One of the nanomaterials that can be useful for this purpose is Mesporous Silica Nanoparticle or MSN. This article provides a review that discusses how MSN can deliver drugs, the synthesis method and its level of ability in DDS. MSN showed that its ability to deliver various types of drugs including Ibuprofen, Doxorubicin and general antibiotics. The results of the synthesis can use solution based and EISA where the release properties in DDS are quite effective. This shows that MSN is good for the use of CDDS.

Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride

“…The porosity of the composite can have an impact on the adsorption and release of TCH drugs. The release of TCH drugs is also influenced by the competition between the affinity of TCH for the adsorbent surface and its solubility in the release medium 33 . This mathematical drug release model has different regression coefficient (R 2 ) values in the release medium of pH 6.86, shown in Table 2.…”

Perkembangan Sintesis MCM-41 Berbasis Sumber Daya Alam dan Aplikasinya: Sebuah Telaah Pustaka

“…Sistem pengantaran obat (Drug Delivery System atau DDS) merupakan suatu sistem untuk mengirimkan obat yang telah digunakan secara klinis dan pra-klinis dalam pengobatan suatu penyakit yang dihantarkan melalui asupan oral atau injeksi ke pembulu darah. Nanopartikel silika mesopori salah satu alternatif pembawa obat yang prospektif karena bentuk mesoporinya yang khas layaknya sarang lebah yang memungkinkan fungsionalitas permukaan sehingga pelepasan obat yang terkontrol sesuai target dari berbagai molekul obat dapat tercapai [15]. Banyaknya kelebihan sifat fisik dan kimia MCM-41 menyebabkan penggunaannya meningkat tajam.…”