Mesoscale regulation of droplet templates to tailor microparticle structures and functions

Peng, Han‐Yu; Wang, Wei; Xie, Rui; Ju, Xin; Liu, Zhuang; Faraj, Yousef; Chu, Liang‐Yin

doi:10.1016/j.partic.2018.10.003

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…Microfluidic technology is an emerging strategy for the production of highly controlled and uniform microspheres (Li et al, 2018 ; Brzeziński et al, 2019 ; Kim et al, 2019 ; Zou et al, 2019 ; He et al, 2020 ; Peng et al, 2020 ; Zeng et al, 2020 ; Caballero Aguilar et al, 2021 ). The entire process of droplet formation is performed in a microfluidic device containing micron-sized channels.…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

“…In the microfluidic system, the chemical composition of the droplets can be changed according to the change of the constituent fluid (Duncanson et al, 2012 ). The droplet size can also be controlled according to the flow rate of different phases, which makes the technique very suitable for the preparation of highly complex drug delivery carriers (Rezvantalab and Keshavarz Moraveji, 2019 ; Peng et al, 2020 ). Also, microfluidic devices with specific shape microchannels can be designed to meet the functional and structural needs of different microspheres to realize the customization of microspheres (Li et al, 2018 ).…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

“…Also, microfluidic devices with specific shape microchannels can be designed to meet the functional and structural needs of different microspheres to realize the customization of microspheres (Li et al, 2018 ). However, the microfluidic method used in the experiment often has low production efficiency and can not achieve mass production (Kim et al, 2019 ; Rezvantalab and Keshavarz Moraveji, 2019 ; Peng et al, 2020 ). Therefore, some improvement measures are needed to solve this problem.…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

“…Saraf Nawar et al (Nawar et al, 2020 ) proposed to parallelize the microfluidic device to realize a chip containing multiple droplet generators at the same time, as shown in Figure 4 . Such a droplet generator with a multi-layer geometry structure can greatly simplify the droplet production process and improve production efficiency (Peng et al, 2020 ).…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

310

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

See 2 more Smart Citations

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

310

106

View full text Add to dashboard Cite

show abstract

“…Microfluidic technology has a great development space in the field of microspheres. In addition to achieving uniform and controllable particle size, the internal structure of the microspheres can also be customized to develop microspheres with ideal pharmacokinetic curves and loading capacity (Peng et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

Liu

Tan

et al. 2022

Drug Delivery

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Microspheres play an important role in controlling drug delivery and release rate accurately. To realize the sustainable release of insoluble small-molecule drugs, a new three-phase flow-focusing microfluidic device was developed to produce the drug-loaded sustained-release microspheres which were prepared with bicalutamide (BCS class-II) as the model drug and poly(lactide-co-glycolide) (PLGA) as the carrier material. Under optimized prescription conditions, the microspheres showed a smooth surface and uniform size of 51.33 μm with a CV value of 4.43%. Sustained-release microspheres had a releasing duration of around 40 days in vitro without any initial burst release. The drug release mechanism of the microspheres was drug diffusion and polymer erosion. Meanwhile, the drug release of microspheres in vivo could be up to 30 days. Briefly, the microfluidic device in this study provides a new solution for the preparation of sustained-release microspheres for insoluble small-molecule drugs. PLGA sustained-release microspheres developed by the microfluidic device have good application prospects in precise delivery and sustainable release of insoluble small-molecule drugs.

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Multi-chamber microcapsule generation for cell culture using a high- and low-volume centrifuge-based droplet shooting device

Petersen

Asangba

2023

Microfluid Nanofluid

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Mesoscale regulation of droplet templates to tailor microparticle structures and functions

Cited by 10 publications

References 41 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

Multi-chamber microcapsule generation for cell culture using a high- and low-volume centrifuge-based droplet shooting device

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