Messungen der Diffusion von Eiweißkörpern

Abstract

Band 66 1 V. Weimarn, Herstellung disperser Systeme 11 Heft 1 (1934)1 2. Durch die G e i s e r m e t h o d e (explosives Aufkochen yon Flfissigkeit im Innern yon kaltem Dispersionsmittel) und die D a m p f e x p l o s i o n sm e t h o d e (Explosion yon D~impfen im Innern von kaltem Dispersionsmittel) haben wir disperse Systeme yon Quecksilber, Selen und Schwefel erhalten. 3. Die kolloiden L6sungen von Quecksilber und Selen sind sehr stabil. Die Konzentrationen dieser L6sungen betragen nur einige tausendstel Prozent (z. B. far Quecksilber 0,005 Proz., ffir Selen 0,006 Proz.). 9 4. Die Stabilit~t der kolloiden L6sungen dieser drei Stoffe ist zu erkl~iren durch die Anwesenheit yon 16slichen Verbindungen im Dispersionsmittel, welche mit dem kolloidzerteiltem Stoff gemeinsame Atome haben. Ohne diese Verbindungen sind die kolloiden L6sungen instabil.Weitere Versuche sind im Oange, die Untersuchungen werden yon dem einen yon uns (N. S a t a ) in verschiedenen Richtungen fortgesetzt.

The Calibration of Diffusion Membranes and the Calculation of Molecular Volumes From Diffusion Coefficients

“…to be 1.45 cmY/day). The value of Tiselius and Gross (1934) for the diffusion coefficient of hemoglobin which is 9 per cent higher than that obtained by Tiselius and Gross. As yet there has not been a sufficiently detailed study of the diffusion of any protein by both the classical and the membrane methods to prove that the two methods when applied to proteins yield exactly the same results.…”

Studies of Hemoglobinemia and Hemoglobinuria Produced in Man by Intravenous Injection of Hemoglobin Solutions

“…These authors (23) conclude that proteins are excreted by the normal kidney according to the physical size of their molecules, but that hemoglobin has a peculiar place in this scheme. In our study small amounts of hemoglobin appeared in the urine at very low plasma hemoglobin levels after hemoglobin injections in the patients with preexistent glomerular inj.ury and albuminuria (Figure 2 (24,25); it is presumed, however, that no dissociation occurs in the plasma, since studies in dogs have shown that below a certain plasma concentration hemoglobin does not filter through the glomeruli (20). 8 Although the nature of this protein was not identified, the significance of its presence in the urine in relation to glomerular filtration would seem to be the same, whether the protein is albumin or a plasma protein derived from hemoglobin, since it did not appear in the urine in the absence of hemoglobinuria.…”

Human Glomerular Permeability and Tubular Recovery Values for Hemoglobin

“…The association of proteinuria with decreased glomerular filtration rate and renal blood flow has been observed by others (16,17). Especially pertinent to this hypothesis is the observation of White and Rolf (16) that during heavy exercise a group of normal subjects developed a marked decrease in glomerular 4 It is possible that some degree of dissociation of the hemoglobin molecule might occur at the low plasma concentrations employed in this study (9,10), but the absence of any quantitative information on this possibility precludes consideration here. filtration rate and renal blood flow.…”