Meta-analyses of cavum septum pellucidum in mood disorders in comparison with healthy controls or schizophrenia

Beraldi, Gabriel Henrique; Prado, Kelly S.; Amann, Benedikt L.; Raduà, Joaquim; Friedman, Lee; Elkis, Hélio

doi:10.1016/j.euroneuro.2018.10.001

Cited by 12 publications

(6 citation statements)

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“…One hurdle in pursuing an investigation of the CSP in clinical population, is the uncertainty regarding the prevalence of CSP in healthy adults, stemming from differences in detection method, definition criteria, and homogeneity of the population (23,(28)(29)(30)(31)(32)(33). Abnormally large CSP was repeatedly linked to schizophrenia (23,28,38,(29)(30)(31)(32)(34)(35)(36)(37), bipolar disorders (31,39,40), and others psychopathologies (41,42), when compared to healthy controls. Yet, other studies did not find higher rates of enlarged CSP in schizophrenia (43)(44)(45) or other psychiatric disorders(46-49).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Risk Factors for Post Traumatic Stress Disorder (PTSD) in Recent Trauma Survivors

Ben‐Zion

Artzi

Niry

et al. 2019

Preprint

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Background: Low hippocampal volume could serve as an early risk factor for Post-traumatic Stress Disorder (PTSD) in interaction with other brain anomalies of developmental origin. One such anomaly may well be a presence of large Cavum Septum Pellucidum (CSP), which has been loosely associated with PTSD. Here, we performed a longitudinal prospective study of recent trauma survivors. We hypothesized that at one-month after trauma exposure, the relation between hippocampal volume and PTSD symptom severity will be moderated by CSP volume, and that this early interaction will account for persistent PTSD symptoms at subsequent time-points. Methods: 171 adults (87 females, average age=34.22, range=18-65) admitted to a general hospital's emergency department following a traumatic event, underwent clinical assessment and structural MRI within one-month after trauma. Follow-up clinical evaluations were conducted at six (n=97) and fourteen (n=78) months after trauma. Hippocampus and CSP volumes were measured automatically by FreeSurfer software and verified manually by a neuroradiologist.Results: At one-month following trauma, CSP volume significantly moderated the relation between hippocampal volume and PTSD severity (p=0.026), and this interaction further predicted symptom severity at fourteen months post-trauma (p=0.018). Specifically, individuals with smaller hippocampus and larger CSP at one-month post-trauma, showed more severe symptoms at one-and fourteen months following trauma exposure. Conclusions:Our study provides evidence for an early neuroanatomical risk factors for PTSD, which could also predict the progression of the disorder in the year following trauma exposure.Such a simple-to-acquire neuroanatomical signature for PTSD could guide early management, as well as long-term monitoring. Trial Registration: Neurobehavioral Moderators of Post-traumatic Disease Trajectories. ClinicalTrials.gov registration: NCT03756545. https://clinicaltrials.gov/ct2/show/NCT03756545 National Institute of Mental Health (NIMH) given to AS (PI), IL and TH (co-Investigators, subcontractors), and had undergone critical review by the NIMH Adult Psychopathology and Disorders of Aging study section. Nevertheless, the NIMH had no role in the design, execution, data management and data analysis of the current study. Sagol School of Neuroscience at Tel-Aviv University supported ZB fellowships, and Sagol Brain Institute at Tel-Aviv Sourasky Medical Center supported NK and HS fellowships. A preliminary version of this work was previously published in Biorxiv (https://www.biorxiv.org/content/10.1101/721068v1). Disclosures:The authors declare that they have no financial disclosures and no conflict of interests.As mentioned in the participants section, the present study is part of a larger on-going project that examines PTSD development in trauma survivors. The authors declare that they report all measures, conditions and data exclusions, as pertain to outlined hypotheses, obtained from all the participants who completed assessments within one-m...

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Section: Introductionmentioning

confidence: 99%

Neuroanatomical Risk Factors for Post Traumatic Stress Disorder (PTSD) in Recent Trauma Survivors

Ben‐Zion

Artzi

Niry

et al. 2019

Preprint

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“…112,113 Finally, groups of psychiatrists based at other public universities in different states in Brazil have regularly published wellcited systematic reviews and meta-analyses on several neuroimaging topics. [114][115][116][117][118][119][120][121][122][123][124][125] There are two additional Brazilian research centers dedicated primarily to neurophysiology and neurology that deserve to be mentioned here. At the privately funded Albert Einstein Israelite Hospital in Sã o Paulo, a group of neuroradiologists and neuroscientists has conducted a series of MRI investigations evaluating interventions of potential interest to psychiatry using yoga-based and other meditation methods.…”

Section: Psychiatric Neuroimaging In Brazilmentioning

confidence: 99%

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

Busatto

Rosa

Squarzoni

et al. 2021

Braz. J. Psychiatry

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The last four decades have witnessed tremendous growth in research studies applying neuroimaging methods to evaluate pathophysiological and treatment aspects of psychiatric disorders around the world. This article provides a brief history of psychiatric neuroimaging research in Brazil, including quantitative information about the growth of this field in the country over the past 20 years. Also described are the various methodologies used, the wealth of scientific questions investigated, and the strength of international collaborations established. Finally, examples of the many methodological advances that have emerged in the field of in vivo neuroimaging are provided, with discussion of the challenges faced by psychiatric research groups in Brazil, a country of limited resources, to continue incorporating such innovations to generate novel scientific data of local and global relevance.

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“…During normal fetal development, the two leaves of the septum are separated and form a cavity referred to as the cavum septum pellucidum (CSP), fusing back together around 36 weeks gestation so that only about one-third of term infants maintain the fetal state ( 3 ). While the presence of a CSP is considered to be a normal neurodevelopmental anatomical variation in some people ( 4 , 5 ), it is also considered to be a neurodevelopmental abnormality in people with bipolar disorder ( 6 – 8 ), posttraumatic stress disorder ( 9 , 10 ), schizophrenia spectrum disorders ( 6 , 8 , 11 , 12 ), and telomere biology disorders ( 13 ). A substantial percentage of the general population has a CSP, and the reported percentages vary considerably based on the method used to identify it.…”

Section: Introductionmentioning

confidence: 99%

Examining for Cavum Septum Pellucidum and Ventricular Enlargement in Retired Elite-Level Rugby League Players

et al. 2022

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ObjectiveA cavum septum pellucidum (CSP) has been reported as a visible brain anomaly in normal individuals as well in some former combat and collision sport athletes. The appearance of CSP with fenestrations and ventricular enlargement are considered associated features of the neuropathological diagnosis of chronic traumatic encephalopathy. The current study examined CSP anatomic features and lateral ventricle size in retired elite rugby league players and controls.MethodsForty-one retired rugby league players and 41 healthy community controls, similar in age and education, underwent structural MRI scans. CSP grade, CSP length, corpus callosum septal length, and Evans' ratio (for lateral ventricle size) were rated by two of the current study authors. All participants also self-reported concussion exposure histories, depressive symptoms, daytime sleepiness, and impulsivity. They completed a neuropsychological test battery assessing premorbid intellectual functioning, attention, processing speed, language, visuospatial skills, memory, and aspects of executive functioning.ResultsThe two raters had high agreement for CSP grade (Cohen's κ = 0.80), CSP length [intraclass correlation (ICC) = 0.99], corpus callosum septal length (ICC = 0.73), the CSP/septal ratio (ICC = 0.99), and the Evans' ratio (ICC = 0.75). Twenty-five retired players (61.0%) had an abnormal CSP compared to 17 controls [41.5%; χ(1, 82)2 = 3.12, p = 0.08, odds ratio = 2.21]. The CSP/septal ratio was larger for retired players than for the controls. The Evans' ratio did not differ between the two groups. In the retired rugby league players (n = 41), those with normal (n = 16) and abnormal (n = 25) CSP grades did not differ across age, age of first exposure to collision sport, years of sport exposure, concussion history, or 23 clinical and cognitive variables.ConclusionThis study revealed a difference in the size of the CSP between retired professional rugby league players and controls. There was no significant difference in the size of the ventricles between the two groups. There were no significant differences between those with vs. without an abnormal CSP on age of first exposure to rugby league, years of exposure to repetitive neurotrauma, number of lifetime concussions, depression, impulsivity, perceived cognitive decline, or on any neuropsychological test.

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Meta-analyses of cavum septum pellucidum in mood disorders in comparison with healthy controls or schizophrenia

Cited by 12 publications

References 64 publications

Neuroanatomical Risk Factors for Post Traumatic Stress Disorder (PTSD) in Recent Trauma Survivors

Neuroanatomical Risk Factors for Post Traumatic Stress Disorder (PTSD) in Recent Trauma Survivors

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

Examining for Cavum Septum Pellucidum and Ventricular Enlargement in Retired Elite-Level Rugby League Players

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