Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality

Huan, Luyao; Deng, Xiangling; He, Mengyang; Chen, Shunhong; Niu, Wenquan

doi:10.1155/2021/6636856

Cited by 16 publications

(16 citation statements)

References 45 publications

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“…Results of UK Biobank on early natural menopause were associated with a increased risk for a composite of CVD may have a "healthy participant" selection bias (42). The following studies are consistent with our findings on no convincing relationship between early menopausal age and cardiovascular disease (12,(43)(44)(45)(46)(47). Differences in population and study design and the influence of confounding factors may be the main reasons for the inconsistent results.…”

Section: Discussionsupporting

confidence: 84%

Age at Menarche and Menopause, Reproductive Lifespan, and Risk of Cardiovascular Events Among Chinese Postmenopausal Women: Results From a Large National Representative Cohort Study

Chen

Wang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAt present, the association between age at menarche and menopause, reproductive lifespan, and cardiovascular disease (CVD) risk among Chinese postmenopausal women is not clear, and some related researches are contradictory.MethodsA total of 6,198 Chinese postmenopausal women with a mean age of 63.6 years were enrolled at baseline in 2012–2015 and followed up for 5 years. A standardized questionnaire was used to collect relevant information by well-trained interviewers. Physical examination of the participants was performed by trained medical staff. CVD events were observed during follow-up. Cox proportional hazards models were used to estimate hazard ratios between reproductive characteristics and CVD events.ResultsAge at menarche was positively associated with CVD events (HR, 1.106; 95%CI, 1.047–1.167). There was a negative association between age at menopause and CVD risk in postmenopausal women with comorbidity (HR, 0.952; 95%CI, 0.909–0.996). Reproductive lifespan was negatively associated with CVD events (HR, 0.938; 95%CI, 0.880–0.999). The CVD risk increased by 10.6% for every 1-year increase in age at menarche. The CVD risk reduced by 6.2% for every 1-year increase in age at menopause in women with comorbidity. The CVD risk reduced by 3.8% for every 1-year increase in reproductive lifespan.ConclusionsBased on the large prospective study with a nationally representative sample, Chinese postmenopausal women with late age at menarche and shorter reproductive lifespan have higher risk of CVD events.

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Section: Discussionsupporting

confidence: 84%

Age at Menarche and Menopause, Reproductive Lifespan, and Risk of Cardiovascular Events Among Chinese Postmenopausal Women: Results From a Large National Representative Cohort Study

Chen

Wang

et al. 2022

Front. Cardiovasc. Med.

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“…Despite the significant stress factors of the early age period, both patients showed a maintenance of normal reproductive function and the timely onset of menopause that may also be associated with a healthy aging trajectory ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Rotar

Boyarinova

Moguchaya

et al. 2022

Front. Cardiovasc. Med.

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Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.

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“…When ovarian function failure occurs before the usual age of menopause then it is referred to as premature or early menopause. Menopause occurring before the age of 40 years is considered premature menopause and between 40 and 44 years is early menopause , 1–3 since the natural age of menopause lies between 45 and 55 years 4 . Worldwide, natural menopause can vary country‐wise, with 46.2 years in India, 5 45 years in Thailand, 6 49.2 years in Korea, 7 and 51 years in Bangladesh and the United States 8 .…”

Section: Introductionmentioning

confidence: 99%

Study on depletion of ovarian function and late‐life chronic diseases in India

Kundu

Acharya

2023

Intl J Gynecology & Obste

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ObjectiveThe current study aims to understand premature and early menopausal age in association with chronic conditions.MethodsThe present cross‐sectional study analyzed nationally representative data from LASI (Longitudinal Aging Study in India) from 2017 to 2018. Bivariate analysis including cross‐tabulation and χ2 tests were performed. Further multiple regression analysis was performed, using the generalized linear model of logit link.ResultsApproximately 2533 (8%) older women reported that they had experienced premature menopause (before age 40), while 3889 (12.4%) reported having early menopause (age 40–44). The likelihood of a woman with premature menopause developing cardiovascular diseases (CVDs) is 15% higher (adjusted odds ratio [AOR], 1.15; P < 0.05) than those who do not experience premature menopause, while women with early menopause have a 13% higher risk (AOR, 1.13; P < 0.05). For women who experienced premature menopause and were also smokers, the probability of developing CVDs was higher. Other chronic diseases such as bone or joint problems, diabetes, and eye vision problems were also shown to be significant health problems among women who had premature ovarian failure.ConclusionOur results show significant association between women with premature or early depletion of ovarian function and chronic health conditions such as cardiovascular diseases, bone or joint problems, vision problems, and neurological or psychiatric disorders at their later life ages. Comprehensive strategies in the form of lifestyle changes may regulate hormonal levels and allow the body to reach menopause at the appropriate age.

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Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality

Cited by 16 publications

References 45 publications

Age at Menarche and Menopause, Reproductive Lifespan, and Risk of Cardiovascular Events Among Chinese Postmenopausal Women: Results From a Large National Representative Cohort Study

Age at Menarche and Menopause, Reproductive Lifespan, and Risk of Cardiovascular Events Among Chinese Postmenopausal Women: Results From a Large National Representative Cohort Study

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Study on depletion of ovarian function and late‐life chronic diseases in India

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