Meta-Analysis: Obesity and the Risk for Gastroesophageal Reflux Disease and Its Complications

Hampel, Howard; Abraham, Neena S.; El–Serag, Hashem B.

doi:10.7326/0003-4819-143-3-200508020-00006

Cited by 1,078 publications

(757 citation statements)

References 52 publications

Supporting

Mentioning

674

Contrasting

Unclassified

Order By: Relevance

“…This association was even more pronounced in males, and after adjustment for potential confounders, such as age, gender, and race, the observed associations of adiponectin with BE remained significant. Obesity is shown to be an independent risk factor of GERD23 through increased transient lower esophageal sphincter relaxation, which is an important mechanism of GERD 24. These results were compatible with our study, which demonstrated that weight and BMI was significantly high in Group III (severe GERD) in comparison to the control group.…”

Section: Discussionsupporting

confidence: 92%

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

et al. 2018

View full text Add to dashboard Cite

Background and AimVisceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.MethodsIn this study, 150 subjects were selected and divided into four groups: Group І (n = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ (n = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ (n = 40) were patients with severe erosive esophagitis; and finally, Group ІV (n = 20) were patients with Barrett's esophagus. Upper gastrointestinal endoscopy was performed for Groups II, III, and IV only, and histopathological assessment was conducted for the suspicious cases of Barrett's esophagus. The measurement of serum adiponectin was performed for all groups using the ELISA test.ResultsOur results revealed that the serum level of adiponectin was significantly lower in patients with different grades of GERD as well Barrett's esophagus as compared to healthy controls (P‐value < 0.001). Additionally, the serum level of adiponectin was correlated with different grades of GERD as the highest level of the adiponectin was found in the control group (11.05 ± 2.58) followed by mild to moderate GERD (6.39 ± 1.64) and then severe GERD (2.42 ± 1.00); finally, the lowest level was detected in the Barrett's esophagus group (1.99 ± 0.47). Our study showed significant correlation between body mass index, waist circumference, and waist–hip ratio on one hand and serum adiponectin level on the other hand, with a statistically significant difference (P‐value < 0.001). The best cut‐off value for serum adiponectin was 7.7 (μg/mL), with a sensitivity of 91.8% and specificity of 97.5%.ConclusionsLow serum adiponectin level appears to be associated with an increased risk of erosive esophagitis, and visceral fat accumulation is related to the impaired secretion of adiponectin, which may have an influence on the pathogenesis of GERD.

show abstract

Section: Discussionsupporting

confidence: 92%

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In a meta-analysis of nine studies, Hampel, et al noted that obesity is associated with a statistically significant increase in the risk of esophageal adenocarcinoma. The odds ratio for developing EAC was 1.52 (95 % CI 1.147-2.009) for those with a BMI of 25 to 30 kg/ m 2 and increased to 2.78 (95 % CI 1.850-4.164) for those with a BMI greater than 30 kg/m 2 [11]. Similarly, Lanergern et al reported a weight-dependent relation between BMI and EAC and documented that obese persons with a BMI greater than 30 kg/m (2) had the highest risk (OR=16.2, CI 6.3-41.4) [12].…”

Section: Discussionmentioning

confidence: 96%

Variations in the Histopathologic Type of Esophageal Carcinoma Between the United States of America and India

Kolkman

Stack

McCarthy

et al. 2015

Indian J Surg Oncol

View full text Add to dashboard Cite

The aim of this study was to compare the incidence of the different histopathologic types of esophageal carcinoma between the United States of American (US) and India. The Surveillance Epidemiology and End Result (SEER) database was analyzed to determine the incidence of different types of esophageal carcinoma in US. A retrospective review was conducted of all the patients that underwent resection for esophageal carcinoma at a regional oncology center in India from 2001 to 2007. Data relating to histopathologic variables was collected and compared to the patients in the SEER database for the same time period. Esophageal adenocarcinoma accounts for the majority of newly diagnosed cases in the US. Although squamous cell carcinoma is the dominant type of esophageal carcinoma in India, we noted a small but gradual increase (0 % in 2001 to 28 % in 2007) in the incidence of esophageal adenocarcinoma. The results of our study demonstrate a geographic variation in the histopathologic type of esophageal carcinoma. A recent increase in the incidence of esophageal adenocarcinoma in India was also demonstrated. Analysis of risk factors known to be associated with esophageal adenocarcinoma, in the context of India, can provide targets for implementing public health measures.

show abstract

“…8 High BMI is a risk factor for gastroesophageal reflux disease (GERD) and, consequently, for EAC. [9][10][11] Several studies have reported that high BMI was not associated with improved or reduced overall survival (OS) after esophagectomy, [12][13][14] although increased postoperative morbidity, such as respiratory complications, anastomotic leaks, and length of hospital stay, have been associated with high BMI in patients with gastroesophageal cancer who are undergoing surgery. 14,15 Many of these studies included small number of patients, in whom adjunctive therapy (preoperative chemotherapy and/or radiotherapy) was used.…”

mentioning

confidence: 99%

The influence of high body mass index on the prognosis of patients with esophageal cancer after surgery as primary therapy

Hayashi¹,

Correa²,

Hofstetter³

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND: High body mass index (BMI), a prevalent condition in the United States, is associated with esophageal adenocarcinoma (EAC). Its influence on a patient's outcome remains unclear. In the current study, the authors examined the impact of BMI on survival and complications in patients with esophageal cancer (EC) who underwent surgery as their primary therapy. METHODS: The authors retrospectively reviewed 301 consecutive EC patients who underwent surgery but received no adjunctive therapy. Patients were segregated into 2 subgroups based on their baseline BMI: normal/low (<25 kg/m 2 ) and high ( 25 kg/m 2 ). RESULTS: Seventy-six (25%) patients had a BMI <25 kg/m 2 and 225 (75%) patients had a BMI 25 kg/m 2 . In the high BMI group, there were more men (P < .001), fewer upper ECs (P ¼ .021), a lower baseline clinical stage (P ¼ .006), and frequent EAC (P < .001). Postoperative morbidity was similar in both groups, with the exception of gastrointestinal complications (P ¼ .016). The 5-year overall survival (OS) rates were 44% in the normal/low BMI group and 60% in the high BMI group (P ¼ .017). The 5-year disease-free survival (DFS) rates were 41% in the normal/low BMI group and 60% in the high BMI group (P ¼ .005). On multivariable analysis, age, weight loss, peripheral vascular disease (PVD), and both clinical and pathological stage of disease were found to be independent prognosticators for OS. Older age (hazard ratio [HR]

show abstract

Meta-Analysis: Obesity and the Risk for Gastroesophageal Reflux Disease and Its Complications

Abstract: Obesity is associated with a statistically significant increase in the risk for GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. The risk for these disorders seems to progressively increase with increasing weight.

Cited by 1,078 publications

References 52 publications

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

Variations in the Histopathologic Type of Esophageal Carcinoma Between the United States of America and India

The influence of high body mass index on the prognosis of patients with esophageal cancer after surgery as primary therapy

Contact Info

Product

Resources

About