Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

Chen, Weifeng; Wu, Qianlan; Ren, Hongbo

doi:10.3892/br.2013.181

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…The G allele was revealed to act as a key factor for increasing the risk of GC, which is consistent with the study by Pan et al (29). In addition, in a meta-analysis, Chen et al (30) proposed that the G allele of the MDM2 T309G polymorphism is a high risk factor for developing GC. In the present study, a statistically significant difference was identified in the GG genotype distribution between GC patients and control subjects in the investigated Turkish population (OR=4.58; 95% CI, 1.18-17.79; P=0.022; Table III).…”

Section: Discussionsupporting

confidence: 78%

Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

et al. 2017

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Abstract. Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish population. In the present case-control study, the aim was to investigate the association between genetic polymorphisms of the MDM2 gene (a major regulator of p53 function) and primary GC risk in a Turkish population. The polymorphism, T309G (rs2279744) in the MDM2 gene was determined in patients with GC (n=65) and in healthy control subjects (n=67) using the polymerase chain reaction-restriction fragment length polymorphism method. The findings were evaluated using logistic regression and χ 2 tests. No statistically significant differences were observed between the control subjects and patients with GC regarding smoking status. A comparison between GC cases and control subjects indicated a statistically significant difference for family history of cancer [odds ratio (OR)=0.17; 95% confidence interval (CI), 0.05-0.56; χ 2 =0.19; P=0.01]. A significant difference was identified in the GG genotype distribution between GC patients and control subjects (OR=4.58; 95% CI, 1.18-17.79; P=0.022). Thus, the results of the present study indicate that the MDM2 gene T309G intron (GG) genotype may be an important risk factor for GC development in the Turkish population.

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Section: Discussionsupporting

confidence: 78%

Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

et al. 2017

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“…Moreover, another MDM2 polymorphism (I/D) has been described in the promoter, which may affect the MDM2 expression (Bond et al, 2004;Hu et al, 2006) Considering the role of MDM2 in tumorigenesis, numerous investigations have been made on the effects of MDM2 polymorphisms on various diseases including cancers and several meta-analyses are published with conflicting results (Chen, Wu, & Ren, 2014;Duan & Li, 2017…”

Section: Discussionmentioning

confidence: 99%

“…In the meta‐analysis studies conducted by Chen et al (); Duan & Li. (); Zhuo et al () the MDM2 309T>G polymorphism was considered as a susceptibility factor for hepatocellular carcinoma as well as gastric and cervical cancers, respectively (Chen et al, ; Duan & Li, ; Zhuo, Ren, Li, Wu, & Zhou, ). In the meta‐analysis carried out by Xue et al, the MDM2 309T>G polymorphism was regarded as a susceptible factor for endometrial cancer, especially in Caucasians (Xue, Zhu, & Teng, ).…”

Section: Discussionmentioning

confidence: 99%

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Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study

Maruei‐Milan

Heidari

Salimi

2018

Journal Cellular Physiology

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Murine double minute clone 2 (MDM2) protein plays an important role in the regulation of p53 tumor suppressor. Genetic polymorphisms of the MDM2 gene are the candidate variants in susceptibility to various cancers. In the present study, we aimed to investigate the possible effects of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms on papillary thyroid carcinoma (PTC) susceptibility and clinical or pathological features of the disease. A case control study was carried out involving in a total of 131 patients with PTC and 144 healthy controls. Both cases and controls were genotyped for MDM2 309T>G and I/D polymorphisms. There was no significant difference regarding MDM2 309T>G and I/D genotypes between patients with PTC and controls in neither dominant nor recessive and allelic models. The frequency of G‐D haplotype was higher in patients with PTC and this haplotype was associated with a 1.7‐fold increased risk of PTC. The MDM2 309T>G polymorphism was associated with a higher risk of III–IV stages in patients with PTC. The MDM2 ID genotype was significantly higher in patients with PTC less than 40 years and associated with larger tumor size (≥1 cm). In conclusion, the G‐D haplotype but not MDM2 309T>G and I/D polymorphisms were associated with higher risk of PTC. MDM2 309T>G polymorphism was associated with a higher incidence of III–IV stages, however, I/D polymorphism was associated with larger tumor size and a lower age of disease occurrence.

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“…TP53 induces intracellular expression of MDM2, whereas the latter induces the downregulation of TP53, the auto‐regulatory feedback loop between TP53 and MDM2. The relationship between MDM2 SNP309 and GC risk was meaningful, especially in CGA for the H pylori ‐positive population group . Genotype analyses demonstrated that increased risk for development of CGA was correlated with the MDM2 309G and the P53 72Pro allele compared to the P53 72Arg allele and the MDM2 309T in an allele dose‐dependent manner …”

Section: Genetic Risk Factorsmentioning

confidence: 91%

Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives

et al. 2019

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Recent decades have seen an alarming increase in the incidence of cardia gastric adenocarcinoma (CGA) while noncardia gastric adenocarcinoma (NCGA) has decreased. In 2012, 260 000 CGA cases (age‐standardised rate (ASR); 3.3/100 000) and 691 000 NCGA cases (ASR; 8.8/100 000) were reported worldwide. Compared with women, men had greater rates for both the subsites, especially for CGA. Recently, four molecular subtypes of GC have been proposed by the Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG); however, these classifications do not take into account predisposing germline variants and their possible interaction with somatic alterations in carcinogenesis. The etiology of adenocarcinoma of the cardia and the gastroesophageal junction (GEJ) is not known. It is thought that CGA is distinct from adenocarcinomas located in the esophagus or distal stomach, both epidemiologically and biologically. Moreover, CGA is often identified in the advanced stage having a poor prognosis. Therefore, understanding the risk and the role of predisposing factors in etiology of CGA can inform clinical practice and counseling for risk reduction. In this paper, we showed that GC family history, lifestyle, demographics, gastroesophageal reflux disease, Helicobacter pylori infection, and multiple genetic and epigenetic risk factors as well as several predisposing conditions may underlie susceptibility to CGA. However, several genome‐wide association studies (GWASs) should be conducted to identify novel high‐penetrance genes and pathways as well as causal germline variants predisposing to CGA. They must include different ethnic groups, especially from high‐incidence countries for CGA, because some risk loci are ancestry‐specific. In parallel, statistical methods can be developed to identify cancer predisposition genes (CPGs) from tumor sequencing data. It is also necessary to find novel long noncoding RNAs related to the risk of CGA. Taken altogether, new cancer risk prediction models, including all genetic and nongenetic factors influencing risk, should be developed to facilitate risk assessment, disease prevention, and early diagnosis and intervention of CGA in the future.

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Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk

Cited by 10 publications

References 27 publications

Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study

Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives

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