Meta-Analysis of Direct Oral Anticoagulants Compared With Vitamin K Antagonist for Left Ventricle Thrombus

Mir, Tanveer; Sattar, Yasar; Attique, Hassan Bin; Hussain, Tanveer; Alraies, M. Chadi; Sheikh, Mujeeb; Qureshi, Waqas

doi:10.1016/j.carrev.2021.03.001

Cited by 4 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is still a lack of consensus on the optimal antithrombotic regimen for MI and LV thrombus with concurrent ischemic stroke. Meta-analyses have shown a controversial result on the use of direct oral anticoagulants (DOACs) compared to vitamin K antagonists for the treatment of LV thrombus [ 5 , 11 , 12 ]. Randomized studies are needed to assess DOAC efficacy, especially in large thrombus burden populations with concurrent ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

A Difficult Case of Cardio-Cerebral Infarction Syndrome With Left Ventricular Thrombus

Cheong,

Tan,

Kang

et al. 2024

Cureus

View full text Add to dashboard Cite

Left ventricular thrombus is a major complication following myocardial infarction, particularly in patients with anterior myocardial infarction or dilated cardiomyopathies regardless of coronary reperfusion therapy. Embolization of mural thrombus is one of the major causes of large vessel occlusion ischemic stroke. A combination therapy of antiplatelet (single or dual antiplatelet) and anticoagulant is mandatory in the management of myocardial infarction and left ventricular thrombus with or without stroke. To our knowledge, there are no guidelines on the optimal regimen (dual or triple therapies) and timing of administration in cases of cardio-cerebral infarction. It is difficult for clinicians to balance the risks of intracranial hemorrhage and coronary stent thrombosis. Here, we describe the case of a gentleman who had recently undergone coronary intervention and presented with ischemic stroke and left ventricular thrombus, along with the management challenges in this scenario.

show abstract

Section: Discussionmentioning

confidence: 99%

A Difficult Case of Cardio-Cerebral Infarction Syndrome With Left Ventricular Thrombus

Cheong,

Tan,

Kang

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Specifically, DOACs are associated with lower bleeding and mortality rates than VKAs. 14 , 15 , 16 Additional advantages of DOACs include the lack of INR monitoring requirements, easy administration, and the absence of dietary restrictions. According to 2021 AHA guidelines, anticoagulation with DOACs is as effective as VKA in LV thrombus prevention.…”

Section: Discussionmentioning

confidence: 99%

“…Recent meta‐analyses have shown that direct oral anticoagulants (DOACs) can be a reasonable treatment option in patients with LV thrombus. Specifically, DOACs are associated with lower bleeding and mortality rates than VKAs 14–16 . Additional advantages of DOACs include the lack of INR monitoring requirements, easy administration, and the absence of dietary restrictions.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular thrombus in a patient with recurrent ischemic stroke events—The role of echocardiography

Stylianou

Tsampasian

Pavlou

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical Message Cardiac ultrasound is recommended in investigating ischemic stroke events. There is increasing evidence that direct oral anticoagulants can be safely used instead of vitamin K antagonists in the setting of left ventricular thrombus. Abstract Cardioembolic stroke is responsible for an increasing number of ischemic strokes. Compared to other causes of stroke, cardioembolic strokes affect a larger brain area. Left ventricular (LV) thrombi account for up to 10% of cardioembolic strokes. It is essential to identify patients at high risk of LV thrombus formation, such as patients with a history of myocardial infarction, patients with reduced ejection fraction, or patients with cardiomyopathies. We present a patient with an ischemic stroke, and the cardiac ultrasound revealed a reduced ejection fraction and the presence of LV thrombus at the apex. The patient had no prior history of cardiovascular diseases. Even in a resource‐limited setting, cardiac ultrasound is recommended to investigate stroke or transient ischemic attack events, especially in patients with a prior history of myocardial infarction. Although patients with LV thrombus should be treated with oral anticoagulants for at least 3 months, the role of direct oral anticoagulants and the optimal period of anticoagulation in this setting needs further investigation.

show abstract

Outcomes Associated With Novel Oral Anticoagulants and Warfarin in Patients With Cardiac Thrombus Following ST-Segment Elevation Myocardial Infarction

Albaeni,

Li,

Shan

et al. 2025

The American Journal of Cardiology

View full text Add to dashboard Cite

Meta-Analysis of Direct Oral Anticoagulants Compared With Vitamin K Antagonist for Left Ventricle Thrombus

Cited by 4 publications

References 26 publications

A Difficult Case of Cardio-Cerebral Infarction Syndrome With Left Ventricular Thrombus

A Difficult Case of Cardio-Cerebral Infarction Syndrome With Left Ventricular Thrombus

Left ventricular thrombus in a patient with recurrent ischemic stroke events—The role of echocardiography

Outcomes Associated With Novel Oral Anticoagulants and Warfarin in Patients With Cardiac Thrombus Following ST-Segment Elevation Myocardial Infarction

Contact Info

Product

Resources

About