Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer

Lee, Yuan Chin Amy; Cohet, Catherine; Yu, Yang; Stayner, Leslie T.; Hashibe, Mia; Straif, Kurt

doi:10.1093/ije/dyp280

Cited by 221 publications

(187 citation statements)

References 80 publications

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“…Another meta analysis by Lee, et al got an overall RR of 1.51 (95% CI: 1.37-1.67) and 1.12 (95% CI: 0.78-1.60), respectively. And the increased risk among current smokers was consistent when stratified by region, design, sample size and publication period and a positive dose-response relationship was also observed (Lee et al, 2009).…”

Section: Tobaccosupporting

confidence: 54%

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao¹,

Xie²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

127

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Section: Tobaccosupporting

confidence: 54%

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao¹,

Xie²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

127

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“…Alcohol and other risk factors also make a contribution. A meta-analysis that carefully considered the confounding influence of alcohol, HBV, and HCV found RRs of 1.4-1.5 for liver cancer for current versus never smokers [30].…”

Section: Brief Overview Of Smoking-cancer Associationsmentioning

confidence: 99%

The association of active smoking with multiple cancers: national census-cancer registry cohorts with quantitative bias analysis

Blakely

Barendregt

Foster

et al. 2013

Cancer Causes Control

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Purposes (1) Determine the association of multiple cancers with smoking, focusing on cancers with an uncertain association; and (2) illustrate quantitative bias analysis as applied to registry data, to adjust for misclassification of smoking and residual confounding by alcohol and obesity. Methods New Zealand 1981 and 1996 censuses, including smoking questions, were linked to cancer registry data giving 14.8 million person-years of follow-up. Rate ratios (RR) for current versus never smokers, adjusting for age, sex, ethnicity and socioeconomic factors were calculated and then subjected to quantitative bias analysis. Results RR estimates for lung, larynx (including ear and nasosinus), and bladder cancers adjusted for measured confounders and exposure misclassification were 9.28 (95 % uncertainty interval 8.31-10.4), 6.14 (4.55-8.30), and 2.22 (1.94-2.55), respectively. Moderate associations were found for cervical (1.82; 1.51-2.20), kidney (1.29; 1.07-1.56), liver cancer (1.75; 1.37-2.24; European only), esophageal (2.14; 1.73-2.65), oropharyngeal (2.30; 1.94-2.72), pancreatic (1.68; 1.44-1.96), and stomach cancers (1.42; 1.22-1.66). Protective associations were found for endometrial (0.67; 0.56-0.79) and melanoma (0.72; 0.65-0.81), and borderline association for thyroid (0.76; 0.58-1.00), colon (0.89; and CML (0.66;. Remaining cancers had near null associations. Adjustment for residual confounding suggested little impact, except the RRs for endometrial, kidney, and esophageal cancers were slightly increased, and the oropharyngeal and liver (European/other) RRs were decreased. Conclusions Our large study confirms the strong association of smoking with many cancers and strengthens the evidence for protective associations with thyroid cancer and melanoma. With large data sets, considering and adjusting for residual systematic error is as important as quantifying random error.

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“…Cigarette smoking, positive HBeAg carrier status and chronic hepatitis all contribute synergistically to the development of liver cirrhosis (Yu et al, 1997). A meta-analysis showed that tobacco was associated with liver cancer development (Lee et al, 2009). There was a dose-response relationship between the consumption of alcohol and the development of HCC, 'heavy drinkers' having an approximately 3-4 fold risk increase, compared with non-drinkers (Zhang et al,1998).…”

Section: Discussionmentioning

confidence: 99%

Inpatients' Knowledge about Primary Liver Cancer and Hepatitis

Xu²,

Xu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To assess the level of an inpatient population's awareness about hepatitis and primary liver cancer (PLC), the most common type of which is hepatocellular carcinoma (HCC), and then to initiate education of this group. Methods: A survey was conducted with 1300 participants within the inpatient unit in representative tertiary hospitals in the Chaoshan area of China. Structured questionnaires contained demographic data and statements about different aspects of liver cancer and hepatitis. The questionnaires were completed by trained medical practitioners after they had conducted the interviews. Results: One way ANOVA showed that the sample population lacked adequate knowledge about HCC and hepatitis. Stepwise multiple regression analysis demonstrated that the participant's level of education had the greatest impact on their total knowledge score when other variables remained constant. Conclusions: The study demonstrated: a general lack of awareness amongst the participants about the preventative strategies, and the management options available for people with primary liver cancer and hepatitis; education level was an important factor affecting knowledge levels. The demonstrated deficiencies in people's knowledge about hepatitis and HCC, and their lack of subsequent protective behaviours are likely to play an important role in HCC and hepatitis transmission or prevention.

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Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer

Cited by 221 publications

References 80 publications

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

The association of active smoking with multiple cancers: national census-cancer registry cohorts with quantitative bias analysis

Inpatients' Knowledge about Primary Liver Cancer and Hepatitis

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