Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update

Tucker, Wesley J.; Beaudry, Rhys; Liang, Yuanyuan; Clark, Alexander M.; Tomczak, Corey R.; Nelson, Michael D.; Ellingsen, Øyvind; Haykowsky, Mark J.

doi:10.1016/j.pcad.2018.08.006

Cited by 89 publications

(68 citation statements)

References 47 publications

(105 reference statements)

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“…It is recommended that all patients with established CHF (regardless of left ventricular ejection fraction) should be enrolled in an exercise-based cardiac rehabilitation programme with a multi-faceted approach 3,48-51 ( Table 5) [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] . This may also apply to patients with cardiac implantable electronic or ventricular assistant devices.…”

Section: Chfmentioning

confidence: 99%

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

Ambrosetti

Abreu

Corrà

et al. 2020

European Journal of Preventive Cardiology

552

604

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Secondary prevention through comprehensive cardiac rehabilitation has been recognized as the most cost-effective intervention to ensure favourable outcomes across a wide spectrum of cardiovascular disease, reducing cardiovascular mortality, morbidity and disability, and to increase quality of life. The delivery of a comprehensive and ‘modern’ cardiac rehabilitation programme is mandatory both in the residential and the out-patient setting to ensure expected outcomes. The present position paper aims to update the practical recommendations on the core components and goals of cardiac rehabilitation intervention in different cardiovascular conditions, in order to assist the whole cardiac rehabilitation staff in the design and development of the programmes, and to support healthcare providers, insurers, policy makers and patients in the recognition of the positive nature of cardiac rehabilitation. Starting from the previous position paper published in 2010, this updated document maintains a disease-oriented approach, presenting both well-established and more controversial aspects. Particularly for implementation of the exercise programme, advances in different training modalities were added and new challenging populations were considered. A general table applicable to all cardiovascular conditions and specific tables for each clinical condition have been created for routine practice.

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Section: Chfmentioning

confidence: 99%

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

Ambrosetti

Abreu

Corrà

et al. 2020

European Journal of Preventive Cardiology

552

604

View full text Add to dashboard Cite

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“…The decreased exercise capacity and endothelial dysfunction in patients with chronic heart failure can be improved by regular physical exercise. 25 Further, aerobic exercise training improves both oxygen utilization and ejection fraction in elderly patients with heart failure26,27 and reduces arterial stiffness in older adults. 28 …”

Section: Introductionmentioning

confidence: 99%

<p>Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease</p>

Esfandiarei¹,

Hoxha²,

Talley³

et al. 2019

DDDT

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Background: Studies have indicated an association between Alzheimer’s disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease. Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. Methods: In this study, we measured in vivo cardiovascular function in 7-month-old male 3xTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Results: Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3xTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3xTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3xTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was ~33% higher in 3xTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3xTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Conclusion: Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3xTg mouse model of AD can be prevented with exercise training and treatment with resveratrol. The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3xTg mouse support the value of healthy lifestyle factors on cardiovascular health.

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“…After acute myocardial infarction, Jiang et al showed that CR significantly improved LVEF [ 17 ], unlike what was concluded by McGregor et al [ 18 ]. Also, in patients with heart failure with reduced ejection fraction, a meta-analysis of exercise training on LVEF showed that moderate-intensity continuous training significantly increased LVEF (95% confidence interval, CI, 2.08 to 5.50%) [ 19 ]. On the contrary, McKelvie et al showed no significant impact [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Ramadan Fasting on Biochemical and Exercise Parameters among Patients Undergoing Exercise-based Cardiac Rehabilitation

Khorshid¹,

Rifaie²,

Osama³

et al. 2020

Journal of the Saudi Heart Association

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Background Ramadan fasting is an important worship activity for Muslims. It is not known if fasting could have deleterious effect on cardiac patients joining cardiac rehabilitation (CR) program, especially during summer season. Aim To assess the effect of Ramadan fasting on biochemical and exercise parameters among patients undergoing 12-week exercise-based CR program. Patients and methods 53 patients joining CR program in university hospital were included in the study. The patients were divided into two groups according to their Ramadan fasting status. Fasting group included 32 patients, while non-fasting group included 21 patients. All patients underwent supervised exercise-based CR during the month of Ramadan. Plasma osmolality, blood urea and serum creatinine were assessed before CR and during the last week of Ramadan. Lipid profile, echocardiography and exercise parameters were assessed before and after CR program. Results The two groups were similar in baseline characteristics including: risk factors, osmolality, urea, creatinine, lipid profile and hemoglobin values, as well as ejection fraction and exercise parameters. After the program, both groups showed significant improvement in ejection fraction, total cholesterol, LDL and HDL levels. There was also improvement in duration of exercise reached and achieved METs before and after CR program in both groups. An important notice was that fasting did not significantly influence plasma osmolality in either group. Conclusion Ramadan fasting did not change serum osmolality or negatively affect the results of CR among cardiac patients. It appears to be safe to undergo exercise-based CR during Ramadan even in summer season.

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Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update

Abstract: In clinically stable HFrEF patients, MICT is an effective therapy to attenuate LV remodeling with the greatest benefits occurring with long-term (≥6 months) training. HIIT performed for 2 to 3 months is superior to control, but not MICT, for improvement of LVEF.

Cited by 89 publications

References 47 publications

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

<p>Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease</p>

Impact of Ramadan Fasting on Biochemical and Exercise Parameters among Patients Undergoing Exercise-based Cardiac Rehabilitation

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Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update

Abstract: In clinically stable HFrEF patients, MICT is an effective therapy to attenuate LV remodeling with the greatest benefits occurring with long-term (≥6 months) training. HIIT performed for 2 to 3 months is superior to control, but not MICT, for improvement of LVEF.

Cited by 89 publications

References 47 publications

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology

<p>Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer&rsquo;s disease</p>

Impact of Ramadan Fasting on Biochemical and Exercise Parameters among Patients Undergoing Exercise-based Cardiac Rehabilitation

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Product

Resources

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Abstract: In clinically stable HFrEF patients, MICT is an effective therapy to attenuate LV remodeling with the greatest benefits occurring with long-term (≥6 months) training. HIIT performed for 2 to 3 months is superior to control, but not MICT, for improvement of LVEF.

<p>Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease</p>