Meta-analysis of factors related to health services that predict treatment default by tuberculosis patients

Brasil, Pedro Emmanuel Alvarenga Americano do; Braga, José Ueleres

doi:10.1590/s0102-311x2008001600003

Cited by 26 publications

(26 citation statements)

References 47 publications

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“…When the time needed to get to the TCU exceeded 30 minutes, patients were 3.34 times (95% CI: 1.06-10.5) more likely to default from treatment than patients who were less than 30 minutes away. Similar results can be found in the literature [23,24], whether taking into account the distance or the time to get to the health centre. Cost of transport was not an issue in this study, particularly since almost 90% of patients were at a walking distance to the health centre.…”

Section: Discussionsupporting

confidence: 90%

Factors associated with treatment default by tuberculosis patients in Fez, Morocco

Slama¹,

Tachfouti²,

Obtel³

et al. 2013

East Mediterr Health J

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Interruption in tuberculosis (TB) treatment still remains the most important challenge for control of the disease. This study aimed to identify the determinants of TB treatment default in Fez, Morocco. A 1:2 pairmatched case-control study was carried out in the TB control units in Fez. Cases were defaulters to TB treatment and were matched by age and sex to non-defaulters (controls). Of the 320 patients (108 defaulters, 212 controls), 80.6% were male. The main reason for defaulting reported by patients was the sensation of being cured. Predictive factors for treatment default in the multivariate conditional logistic regression analysis, were: relapsed case (adjusted OR = 4.49; 95% CI: 1.87-10.8), current smoking (aOR = 2.10; 95% CI: 1.07-4.14), alcohol use (aOR = 2.92; 95% CI: 1.04-8.19), being more than 30 minutes away from the health centre (aOR = 3.34; 95% CI: 1.06-10.5) and perception of having received insufficient explanation about the disease (aOR = 2.87; 95% CI: 1.53-5.36). The rate of defaulting in Fez can be lowered through targeted and realistic measures.

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Section: Discussionsupporting

confidence: 90%

Factors associated with treatment default by tuberculosis patients in Fez, Morocco

Slama¹,

Tachfouti²,

Obtel³

et al. 2013

East Mediterr Health J

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“…Several studies have been conducted worldwide to identify the personal, environmental and health care factors associated with adherence to treatment 4,5,6,7,8,9,10,11,12 .…”

Section: Introductionmentioning

confidence: 99%

“…To date, only one article, encompassing a narrow spectrum of risk factors for dropping out of treatment, has addressed this issue in Argentina 5 . By using hierarchical factor analysis to explore different types of factors among a sample from selected districts of the Buenos Aires Metropolitan Area, the present study aims to identify individual and environmental (place of residence) determinants of nonadherence to TB treatment and investigate the influence of these different types of factors on adherence.…”

Section: Introductionmentioning

confidence: 99%

Social determinants of nonadherence to tuberculosis treatment in Buenos Aires, Argentina

et al. 2015

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This study aimed to identify the individual and environmental determinants of nonadherence to tuberculosis (TB) treatment in selected districts in the Buenos Aires Metropolitan Area, in Argentina. We conducted a cross-sectional study using a hierarchical model. Using primary and secondary data, logistic regression was performed to analyze two types of determinants. The likelihood of nonadherence to treatment was greatest among male patients. The following factors led to a greater likelihood of nonadherence to treatment: patients living in a home without running water; head of household without medical insurance; need to use more than one means of transport to reach the health center; place of residence in an area with a high proportion of households connected to the natural gas network; place of residence in an area where a large proportion of families fall below the minimum threshold of subsistence capacity; place of residence in an area where a high proportion of households do not have flushing toilets and basic sanitation. Our results show that social and economic factors – related to both individual and environmental characteristics – influence adherence to TB treatment.

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“…Default rate in Kassala State is estimated by 11 and 16% if adding the transfers (Sudan TB Program, 2012). These figures are relatively high in comparison to other countries in the region (which have default rates of 1 to 13% that include transfers).WHO and the Sudan TB treatment protocol have defined defaulting as a "treatment interruption of two consecutive months or more" (Brasil and Braga, 2008). WHO defines transfer out "as a patient who has been transferred to another recording and reporting unit and whose treatment outcome is unknown".…”

Section: Introductionmentioning

confidence: 99%

Factors associated with default from treatment among tuberculosis patients in Kassala State, Sudan 2013

Abdelhadi¹,

E.Mahdi²,

Soghaier³

et al. 2015

J. Public Health Epidemiol.

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Sudan, particularly the eastern part shoulders 8% of TB burden in the World Health Organization (WHO) Eastern Mediterranean Region (EMR). Kassala state is classified as one of the most tuberculosis (TB) affected states in Sudan with annual risk of around 120 new cases per 100,000 of populations. TB medications take a relatively long time to ensure adequate treatment. Default from TB treatment leads to continuation of disease transmission and multidrug resistant TB cases. Default rate in Kassala state is 11% while the globally acceptable rate is below 4%. This study aimed to find out the main risk factors associated with default from TB treatment among pulmonary TB patients in Kassala state in 2013. The study used case control design with (102 cases and 204 controls), structured questionnaire was used to collect socio-demographic factors. Multivariate logistic regression analysis model was built to quantify the association between risk factors and study outcome. Male to female ratio was 3:2, with age ranges between 15 and 85 years and the mean was 44 years ± 17.4 years. Stopping treatment after feeling improved and completing the intensive treatment phase was an important predictor of defaulting. Age and education level are found to be negatively associated with the default from the TB treatment. Stigma was also found to be strongly associated with the default rate. The current DOTS strategy and its components should be further strengthened by raising attention of medical personnel towards the strategy. An effective communication channel between the care provider and the patient should be mainlined to better education and ensuring of maximum adherence to treatment regimen.

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Meta-analysis of factors related to health services that predict treatment default by tuberculosis patients

Abstract: The identification of factors that predict tuberculosis (TB)

Cited by 26 publications

References 47 publications

Factors associated with treatment default by tuberculosis patients in Fez, Morocco

Factors associated with treatment default by tuberculosis patients in Fez, Morocco

Social determinants of nonadherence to tuberculosis treatment in Buenos Aires, Argentina

Factors associated with default from treatment among tuberculosis patients in Kassala State, Sudan 2013

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