Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies

Abstract

BackgroundPublished data showed that the susceptibility of autoimmune diseases (ADs) was associated with the polymorphism rs2910164 in microRNA-146a (miR-146a). However, the results remain controversial so far. Two meta-analyses published in 2013 and 2014 came to opposite conclusions. In order to derive a more precise estimation of the relationship, we performed this meta-analysis.MethodsWe searched the PubMed, OvidSP and CNKI databases (published prior to September 8th, 2014) and extracted data from eligible studies. The procedure of meta-analysis was performed by using the Stata 12.0 software. Random effect model or fixed effect model were chosen respectively, according to the between study heterogeneities.ResultsA total of 24 case-control studies, 11 more than previous meta-analysis on this topic, were involved. We took stratified analyses by different ethnicities and different types of diseases in different genetic models. In Caucasian subgroup, significant increased risks of GC genotype and GC+CC genotype with ADs susceptibility were found in heterozygote model (GC vs GG, OR = 1.38, 95% CI 1.04–1.83, p = 0.024) and dominant model (GC+CC vs GG, OR = 1.37, 95% CI 1.01–1.85, p = 0.041), respectively. Meanwhile, in other disease subgroup, significant increased risks of C allele, CC genotype and GC+CC genotype were found in allele model (C vs G, OR = 1.16, 95% CI 1.04–1.31, p = 0.010), homozygote model (CC vs GG, OR = 1.42, 95% CI 1.10–1.84, p = 0.006) and dominant model (GC+CC vs GG, OR = 1.25, 95% CI 1.04–1.51, p = 0.020), respectively.ConclusionsMiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs.

MicroRNA-146a suppresses IL-17–mediated skin inflammation and is genetically associated with psoriasis

“…21 This SNP has been shown to be associated with several autoimmune diseases. 32 In line with our findings, in the Chinese Han population, where the G allele is the minor allele, the GG/CG genotype was found be associated with increased risk of psoriasis. 24 Interestingly, the protective allele is a minor allele in the white population in which the prevalence of psoriasis is much higher (3% to 4%) 1 than in the Chinese Han population (<1%), 24 in which it represents the major allele.…”

miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis

“…The in silico analysis showed suggestive evidence for presence of two independent psoriasis susceptibility loci in the MIR146A gene region. One marker mapped 853 bp upstream from miR-146a encoding sequence, with the lead variant rs2961920 (OR=1.12, P=0.0015) being in perfect linkage disequilibrium (LD) (r 2 =1) with a functional polymorphism rs2910164 (Luo et al , 2011) reported to be associated with various autoimmune diseases (Li et al , 2015) and with psoriasis in Han Chinese population with the same effect direction (Zhang et al , 2014). An independent association was observed for rs184776122 (OR=0.80, P = 0.005) 37 kb downstream of the MIR146A gene (Supplementary Table S4 online).…”

Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1

“…Ethnicities were categorized as Caucasian, Asian, African, and LatinAmerican. Study quality was judged according to the criteria modified from previous publications [29][30][31] (See Supplementary " Table S1 Scale for methodological quality assessment").…”