Meta-Analysis of Obstructive Sleep Apnea as Predictor of Atrial Fibrillation Recurrence After Catheter Ablation

Ng, C. M.; Liu, Tong; Shehata, Michael; Stevens, Steven; Chugh, Sumeet S.; Wang, Xunzhang

doi:10.1016/j.amjcard.2011.02.343

Cited by 287 publications

(173 citation statements)

References 30 publications

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“…Estudos mostram que pacientes com SAOS apresentam risco 25% maior de recorrência de FA após ablação quando comparados a pacientes sem SAOS 53 . Os pacientes com SAOS apresentam menor sucesso na ablação e mais complicações relacionadas ao procedimento.…”

Section: Arritmias Cardíacasunclassified

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Campostrini

Prado

2014

RNC

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RESUMOIntrodução. A Síndrome da Apneia Obstrutiva do Sono (SAOS) é caracterizada por obstrução parcial ou completa da via aérea superior, de forma intermitente e recorrente durante o sono. As principais manifestações durante o sono incluem roncos, pausas respiratórias, fragmentação do sono, levando a prejuízos diurnos incapacitantes, como sonolência excessiva diurna, alterações cognitivas e cefaléia matinal. Além das manifestações respiratórias clássicas, resulta em alterações metabólicas e hemodinâmicas que predispõem ao desenvolvimento e agravamento de doenças cardiovasculares, tais como hipertensão arterial sistêmica, insuficiência cardíaca congestiva, doença arterial coronariana e arritmias. Objetivo. Abordar aspectos clínicos, fisiopatológicos e diagnósticos da SAOS, bem como seus efeitos deletérios no sistema cardiovascular. Método. Revisão da literatura acerca da SAOS e suas consequências cardiovasculares através de artigos selecionados no PubMed. Conclusão. A apneia obstrutiva do sono e as doenças cardiovasculares têm origem multifatorial e alta prevalência na população mundial. Considerando que as doenças cardiovasculares são a maior causa atual de morbidade e mortalidade no mundo, a determinação de fatores de risco possíveis de controle e tratamento, como a SAOS, torna-se fundamental para prevenção e tratamento das doenças cardiovasculares.Unitermos. Síndrome da Apneia Obstrutiva do Sono, Doenças Cardiovasculares, Hipertensão, insuficiência Cardíaca Congestiva, Doença da Artéria Coronariana, Arritmias Cardíacas.Citação. Campostrini DDA, Prado LBF, Prado GF. Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares. ABSTRACTIntroduction. Obstructive Sleep Apnea Syndrome (OSAS) is characterized by partial or complete obstruction of the upper airway, intermittently and recurrently during sleep. The main manifestations during sleep include snoring, pauses in breathing, sleep fragmentation, resulting in excessive daytime sleepiness, cognitive dysfunction and morning headaches. Besides the classic respiratory symptoms, OSAS results in metabolic and hemodynamic alterations that predispose to the development and worsening of cardiovascular diseases such as hypertension, congestive heart failure, coronary artery disease and arrhythmias. Objective. Reporting clinical, pathophysiological and diagnostic aspects of OSAS and its deleterious effects on the cardiovascular system. Method. Review of literature about OSAS and its cardiovascular consequences through selected articles in PubMed. Conclusion. Obstructive sleep apnea and cardiovascular diseases have multifactorial origin and high prevalence in the global population. Because cardiovascular diseases are the main cause of the current morbidity and mortality worldwide, determining possible treatable risk factors, such as OSAS, it is fundamental to prevention and treatment of cardiovascular diseases.

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Section: Arritmias Cardíacasunclassified

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Campostrini

Prado

2014

RNC

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“…Additionally, a recent meta-analysis, which included 6 studies of 3,995 patients, suggests that patients with OSA have a greater risk of recurrence of AF even after pulmonary vein isolation 48 .…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Lifestyle Modification in the Prevention and Treatment of Atrial Fibrillation

Menezes¹,

Lavie²,

Schutter³

et al. 2015

Progress in Cardiovascular Diseases

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A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTAtrial fibrillation (AF) is the most common arrhythmia worldwide and has a significant impact on morbidity and mortality. Additionally, the incidence and prevalence of AF is expected to increase in the United States and worldwide over the next few decades. While the pathophysiology concerning the development of AF is not completely understood, multiple modifiable, as well as non-modifiable risk factors, for AF development have been discovered.

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“…Patients with OSA are overall more likely to experience the recurrence of AF after pulmonary vein isolation, as well as after pharmacological and electric cardioversion. 42 As for OSA and ED, their concurrence is even more frequent. Almost 70% of male patients with OSA suffer from ED.…”

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confidence: 99%

Obstructive sleep apnea, atrial fibrillation, and erectile dysfunction: are they only coexisting conditions or a new clinical syndrome? The concept of the OSAFED syndrome

Szymański¹,

Puchalski²,

Filipiak‬³

2013

Polish Archives of Internal Medicine

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REVIEW ARTICLE Obstructive sleep apnea, atrial fibrillation, and erectile dysfunction... 701Clinical scenarios A 55-year-old man with diabetes and hypertension was admitted for the ablation of a source of AF. He had been diagnosed with paroxysmal AF 4 years before. His AF attacks caused palpitations, reduced exercise capacity, and breathlessness, and flared as often as once every 3 to 6 months. The symptoms were classified as being European Heart Rhythm Association (EHRA) class III. The patient said that, apart from arterial hypertension and diabetes, he was otherwise healthy. He was taking warfarin, metformin 500 mg bid, ramipril 5 mg od, with good glucose and blood pressure control. AF was recorded both on standard electrocardiogram (ECG) and during 24-hour ambulatory ECG monitoring. He was admitted 1 day prior to the procedure. During the night, other patients complained that he snored very loudly and had episodes of apnea. When he was interviewed, he reported that his wife often complained about his loud snoring and that he experienced daytime sleepiness. He also said that he had been having erectile problems for about 2 years. We decided to proceed with the ablation and scheduled polysomnography after the procedure, and he was referred for further consultation. After performing a transesophageal echocardiography (which did not reveal any thrombi in the left atrial appendage, but showed an enlargement of the left atrium, confirmed also later with transthoracic echocardiography with the following results: left atrium, 5.9 × 6.8 cm; area, 33.7 cm 2 ; volume 135 cm 3 ); the pulmonary vein was isolated. Polysomnography showed an apnea-hypopnea index (AHI) of 43.8/h and a mean night-time blood oxygen saturation of 91.3%. After the diagnosis of severe REVIEW ARTICLEObstructive sleep apnea, atrial fibrillation, and erectile dysfunction: are they only coexisting conditions or a new clinical syndrome? The concept of the OSAFED syndrome AbsTRACTPatients rarely suffer from only 1 disease. Most of them have several conditions with common risk factors and etiology, and which often increase the severity of each other. The phenotypes linked to 1 condition are often linked to many others. We describe 3 patients with obstructive sleep apnea (OSA), atrial fibrillation (AF), and erectile dysfunction (ED), all of which are highly prevalent in the general population. OSA is one of the most common sleep disorders, affecting approximately 24% of men and 9% of women between 30 and 60 years of age. AF is one of the most common arrhythmias, present in approximately 2% of the population, and erectile dysfunction can be found in 18% to 40% of the male population older than 20 years. The presence of these 3 conditions in the same patient may be not only a coincidence but rather a new clinical syndrome. We present data which allow one to consider OSA, AF, and ED as parts of a clinical syndrome: OSAFED (obstructive sleep apnea, atrial fibrillation, and erectile dysfunction), with a larger effect on the cardiovascular risk profile than th...

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Meta-Analysis of Obstructive Sleep Apnea as Predictor of Atrial Fibrillation Recurrence After Catheter Ablation

Cited by 287 publications

References 30 publications

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Lifestyle Modification in the Prevention and Treatment of Atrial Fibrillation

Obstructive sleep apnea, atrial fibrillation, and erectile dysfunction: are they only coexisting conditions or a new clinical syndrome? The concept of the OSAFED syndrome

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