Meta-analysis of recent studies on patients admitted to hospital due to adverse drug effects

Atiqi, Roya; Cleophas, T. J.; Bommel, Eric van; Zwinderman, A. H.

doi:10.5414/cpp47549

Cited by 10 publications

(7 citation statements)

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“…In 2009, the top three events were drug events, fall events and piping events, respectively [7]. Atiqi R. mentioned that ADEs accounted for 3.4-33.9% of all the reasons leading to hospitalization [8].…”

Section: Discussionmentioning

confidence: 99%

Elderly patients with inappropriate medication correlations with adverse drug events or unexpected illnesses in long-term care institutions

Lin¹,

Yeh²,

Lau³

2013

The Aging Male

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Section: Discussionmentioning

confidence: 99%

Elderly patients with inappropriate medication correlations with adverse drug events or unexpected illnesses in long-term care institutions

Lin¹,

Yeh²,

Lau³

2013

The Aging Male

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“…However, comparisons between the studies are limited, particularly because of the absence of a standardized definition of events, and even in the same study, different detection methods were combined and the information on the events characteristics was not presented in most of the studies. 1,2,9,14,53,54 In addition, few articles gave information on the number of drugs used during hospital stay, a factor associated with the outcome 10,11 . Nevertheless, calculation of the summary measure is helpful to quantify study heterogeneity using I 2 and to investigate the sources of variability by meta-regression, and sensitivity and subgroup analysis.…”

Section: Discussionmentioning

confidence: 99%

“…22 Moreover, other systematic reviews have also used the cut-off point of 2000. 5,6,14 Descriptors for the searches in Lilacs were selected from among the DeCs (Descritores em Ciências da Sa ude), and for MEDLINE from among MeSH (Medical Subject Headings) terms. The MEDLINE search terms were adapted for the Embase search.…”

Section: Methodsmentioning

confidence: 99%

“…Pooled estimates can also be explored further through sensitivity analyses. 14 Event frequency is also influenced by case identification method. These include spontaneous reporting, which constitutes the basis for a number of vigilance systems.…”

Section: What Is Known and Objectivementioning

confidence: 99%

“…There are studies that used ADR definitions that include preventable events and studies where their inclusion or exclusion is not clearly specified. 1,3,4,14 To deal with the problem posed by study heterogeneity, strategies adopted have included calculating the frequencies of ADE and ADR separately 3 or including only studies where the ADR definition was similar to WHO's 1 . Pooled estimates can also be explored further through sensitivity analyses.…”

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confidence: 99%

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Adverse drug events among adult inpatients: a meta-analysis of observational studies

2014

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SUMMARYWhat is known and objective: Studies in a number of countries have shown that adverse drug events (ADE) occur frequently among hospital inpatients. The objective of this study was to conduct a systematic review of observational studies of the frequency of ADE in adult inpatients and to examine factors associated with observed heterogeneity in the reported results. Methods: The systematic review included observational studies, which identified and analysed ADE during hospitalization of adult inpatients. The literature search was conducted on MED-LINE, Embase, Lilacs and Google Scholar (January of 2000 to June of 2013). Article selection, quality assessment and information extraction were performed by two of the authors, working independently. Using the random-effects model, the proportion of patients with adverse events was used as an outcome measure. Proportion was estimated for subgroups based on event identification method: stimulated reporting (SR), retrospective monitoring (RM) and prospective monitoring (PM). For the latter group, meta-regression was used to identify sources of heterogeneity in the estimates. Results and discussion: Twenty-eight articles from the 7550 identified met our inclusion criteria. The articles were heterogeneous in terms of quality, outcome definition and event identification method and in the corresponding descriptions. Of the 28 articles selected, 25 were included in the corresponding quantitative summary: four used SR, six RM and 15 PM, returning incidences of 2Á3% (CI 95%: 1Á6-4Á5), 8Á7% (CI 95%: 4Á8-15Á3) and 21Á3% (CI 95%: 15Á7-28Á3), respectively, and I 2 greater than 95%. There were other sources of heterogeneity, including the use of combined strategies within each subgroup. In the PM subgroup, using multivariate meta-regression model, no variables were found to associate with proportion. What is new and conclusion: Event frequency seems to associate with the event identification method. PM returned the highest estimates. This subgroup used a greater diversity of approaches for event identification and more diverse data sources. Improved recording of information on the event identification method, the characteristics of the events and the conduct of the study would enable more reliable and precise estimates of the frequency of ADE among hospital inpatients. WHAT IS KNOWN AND OBJECTIVEHospital studies in a number of countries have identified high incidences of drug-related adverse events occurring during hospital stay. The estimates are high and vary widely across studies. In recent years, meta-analyses have been made to summarize the frequency of such events.1,2 Other reviews of the frequency of drug-related events among adult inpatients have either included only the ones identified at admission 3,4 or did not calculate summary measures. 5,6 Systematic reviews aiming to estimate the prevalence or incidence of events are often complicated by heterogeneity of eligible studies. However, the aim of a meta-analysis is not only to compute a summary measure but also to hig...

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Meta-analysis of recent studies on patients admitted to hospital due to adverse drug effects

Cited by 10 publications

References 0 publications

Elderly patients with inappropriate medication correlations with adverse drug events or unexpected illnesses in long-term care institutions

Elderly patients with inappropriate medication correlations with adverse drug events or unexpected illnesses in long-term care institutions

Adverse drug events among adult inpatients: a meta-analysis of observational studies

Current awareness: Pharmacoepidemiology and drug safety

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