1998
DOI: 10.2337/diacare.21.10.1726
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Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes

Abstract: The results of this meta-analysis demonstrate that in type 1 diabetic patients, the frequency of severe hypoglycemia can be reduced by taking insulin lispro as compared with regular human insulin therapy.

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Cited by 183 publications
(78 citation statements)
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“…Previous reports evaluating pump therapy in children have shown significant reduction in risk of severe hypoglycemia despite improvements in A1c (20,34,35). Furthermore, other reports have suggested that severe hypoglycemia may be less common with insulin analog therapy (36)(37)(38). Although the relationship has not been as strong in pediatric studies (19,20,39), the fact that nearly twice as many patients were using insulin analogs as part of their treatment regimens in 2002 than in 1997 likely contributed to the decreased incidence of severe hypoglycemia in this cohort.…”
Section: Discussionmentioning
confidence: 97%
“…Previous reports evaluating pump therapy in children have shown significant reduction in risk of severe hypoglycemia despite improvements in A1c (20,34,35). Furthermore, other reports have suggested that severe hypoglycemia may be less common with insulin analog therapy (36)(37)(38). Although the relationship has not been as strong in pediatric studies (19,20,39), the fact that nearly twice as many patients were using insulin analogs as part of their treatment regimens in 2002 than in 1997 likely contributed to the decreased incidence of severe hypoglycemia in this cohort.…”
Section: Discussionmentioning
confidence: 97%
“…In a patient treated with basal-bolus insulin, morning fasting hypoglycemia implicates the long-or intermediate-acting insulin; daytime hypoglycemia implicates the rapid or shortacting insulin; nocturnal hypoglycemia may implicate either. Substitution of a preprandial rapid-acting insulin analogue (e.g., lispro or aspart) for short-acting (regular) insulin reduces the frequency of nocturnal hypoglycemia (72)(73)(74). Substitution of a long-acting insulin analogue (e.g., glargine or detemir) for intermediate-acting insulin (NPH or ultralente) may also reduce the frequency of nocturnal hypoglycemia (75)(76)(77).…”
Section: Preventionmentioning
confidence: 99%
“…Estudos prévios demonstraram uma incidência menor de episódios hipoglicêmicos em pacientes em uso de insulina lispro, particularmente episódios noturnos (12)(13)(14)(15)(16). A redução da taxa de hipoglicemia noturna tem sido observada tanto em pacientes diabéticos tipo 1(13-16) quanto em pacientes diabéticos tipo 2 (20).…”
Section: Discussionunclassified