Meta-analysis of the urokinase gene 3′-UTR T/C polymorphism and susceptibility to urolithiasis

Li, Dawei; Liu, Ji‐Kai; Ren, Juchao; Yan, Lei; Liu, Hainan; Xu, Zhonghua

doi:10.3892/br.2013.73

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…Urolithiasis, as a complex and multifactorial disease, is one of the most prevalent disorders in the urological system with increasing incidence. Approximately 5% of females and 12% of males are likely to develop urolithiasis during their lifetime [ 30 ]. A growing body of evidence shows that organic substances, in addition to inorganic substances, may significantly influence the development of urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis

Liu

Pan

et al. 2015

BioMed Research International

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Objective. Previous studies have investigated the relationships between osteopontin gene polymorphism rs1126616 and OPN levels and urolithiasis, but the results were controversial. Our study aimed to clarify such relationships. Methods. A meta-analysis was performed by searching the databases Pubmed, Embase, and Web of Science for relevant studies. Crude odds ratios (ORs) or standardised mean differences with 95% confidence intervals (CIs) were calculated to evaluate the strength of association. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results. Overall, a significantly increased risk of urolithiasis was associated with OPN gene polymorphism rs1126616 for all the genetic models except recessive model. When stratified by ethnicity, the results were significant only in Turkish populations. For OPN level association, a low OPN level was detected in the urine of urolithiasis patients in large sample size subgroup. Results also indicated that urolithiasis patients have lower OPN level in serum than normal controls. Conclusion. This meta-analysis revealed that the T allele of OPN gene polymorphism increased susceptibility to urolithiasis. Moreover, significantly lower OPN levels were detected in urine and serum of urolithiasis patients than normal controls, thereby indicating that OPN has important functions in the progression of urolithiasis.

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Section: Discussionmentioning

confidence: 99%

Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis

Liu

Pan

et al. 2015

BioMed Research International

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“…Case-control studies have also identified genetic polymorphisms associated with kidney stone disease in the following genes: HIPK2 (the protein product of which is thought to have a role in renal tubule epithelial cell apoptosis and renal fibrosis 174 ; SPP1 which encodes an inhibitor of stone formation [175][176][177] ; MGP, the protein product of which inhibits hydroxyapatite nucleation and formation of calcium oxalate monohydrate 178,179 ; and a variant in the 3' UTR of the urokinase gene, which encodes a protein that degrades the organic matrix of kidney stones 180 . Further studies are required to elucidate the role of these genetic polymorphisms in kidney stone pathogenesis.…”

Section: [H2] Case-control Studiesmentioning

confidence: 99%

Genetics of kidney stone disease

2020

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Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute composition including hypercalciuria. Studies suggest that the prevalence of monogenic kidney stone disorders, including renal tubular acidosis with deafness, Bartter syndrome, primary hyperoxaluria, and cystinuria, in patients attending kidney stone clinics is 15%. However, for the majority of individuals, nephrolithiasis has a multifactorial aetiology involving genetic and environmental factors. Nonetheless, the genetic influence on stone formation in these idiopathic stone formers remains considerable and twin studies estimate a heritability of >45% for nephrolithiasis and >50% for hypercalciuria. The contribution of polygenic influences from multiple loci have been investigated by genome-wide association and candidate gene studies, which indicate that a number of genes and molecular pathways contribute to the risk of stone formation. Genetic approaches, studying both monogenic and polygenic factors in nephrolithiasis, have revealed that the following have important roles in the aetiology of kidney stones: transporters and channels; ions, protons and amino acids; the calcium-sensing receptor (a G-protein-coupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, purines and uric acid. These advances, which have increased our understanding of the pathogenesis of nephrolithiasis, will hopefully facilitate the future development of targeted therapies for precision medicine approaches in patients with nephrolithiasis.

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“…Risk factors related to kidney stones are different among different population groups and environmental factors have a key role in their pathogenesis [5]. Research on urological patients has shown that the incidence of kidney stones can be associated with sex, race, geographic region, occupation, hot climate, positive family history, unhealthy diet (excessive intake of caffeine, salt, dairy products, animal proteins and fat) [6], smoking, alcohol consumption, physical activity, obesity, low fluid intake, dehydration [2] socioeconomic status, education [5], water quality [7], high intake of vitamins D and C [8], genetic background [9] and comorbid metabolic disorders (diabetes mellitus, hypertension, chronic kidney disease, and cardiovascular disease) [1].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiologically, about 5% of women and 12% of men experience kidney stones during their lives [9]. Basiri et al which conducted a study on the prevalence of urinary stones among 24 provinces of Iran, reported an average age of 41.5 years for the patients [7].…”

Section: Introductionmentioning

confidence: 99%

Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran

et al. 2021

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Background The prevalence of kidney stones in the world is increasing and environmental factors seem to play a major role in this issue. The aim of the present study was to investigate the prevalence of risk factors of kidney stones in the adult population of Rafsanjan city based on the data of the Rafsanjan Cohort Study (RCS). Methods In the baseline phase of this study, 10,000 people aged 35 to 70 years are enrolled in the RCS, as one of the prospective epidemiological research studies in Iran. From this population, 9932 participants completed related demographic questionnaires as well as reported a history of diabetes mellitus, kidney stone, and hypertension diseases. The obtained data were analyzed using univariable and multivariable logistics regression. Results According to the obtained results, 46.54% of the studied population were male and 53.46% were female. The mean age of the participants was 49.94 ± 9.56 years. 2392 people accounting for 24.08% of the population had kidney stones. After adjustment of the variables, six variables of gender, WSI, no consumption of purified water, BMI, and history of hypertension and diabetes were found to be significant related factors of kidney stone disease. Conclusions Gender, hypertension, obesity, diabetes, and personal habits like alcohol consumption, opium use and, cigarette smoking are effective in the development of kidney stones. So, by identifying the susceptible patients and teaching them, the burden of the disease on society and the individual can be reduced. The results of this study are helpful to health care providers for preventive planning for kidney stone disease.

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Meta-analysis of the urokinase gene 3′-UTR T/C polymorphism and susceptibility to urolithiasis

Cited by 9 publications

References 27 publications

Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis

Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis

Genetics of kidney stone disease

Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran

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