“…A large amount of money is invested annually in fungicide spray programs, and profits are reduced when resistance arises. A recent publication has described, for example, general costs of 45.14 USD/ha for ground application and 51.80 USD/ha for aerial application in corn in the U.S. [ 170 ] or loss of GBP 170 m/year for UK growers to control the cereal eyespot ( Oculimacula yallundae ) during the 1980s [ 171 ]. Moreover, the most common powdery mildew fungi are high-risk pathogens, and as documented in this review, important cases of practical resistance have been reported in several parts of the world, such as Africa, Australia, Brazil, Canada, China, Europe (Austria, Belgium, Czech Republic, Denmark, France, Germany, Greece, Hungary, Italy, Portugal, Scandinavia, Spain and the Netherlands), Egypt, India, Iran, Japan, New Zealand, UK, and the US (California, Georgia, Michigan, New Jersey, New York, North Carolina, Ohio, South Carolina and Virginia).…”