Meta-Analysis on Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography

Ukaigwe, Anene; Karmacharya, Paras; Mahmood, Maryam; Pathak, Ranjan; Aryal, Madan Raj; Jalota, Leena; Donato, Anthony A.

doi:10.1016/j.amjcard.2014.07.059

Cited by 36 publications

(30 citation statements)

References 23 publications

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“…CI-AKI is the third most common cause of hospital acquired acute renal failure [2, 4, 5] and is responsible for about 10–12% of the cases [2, 6–8]. Renal function may deteriorate after RCM use even in the absence of overt CI-AKI [9, 10].…”

Section: Introductionmentioning

confidence: 99%

“…The rise in the use of intravenous RCM for computer tomography (CT) and magnetic resonance imaging (MRI) and angiography [5] (Figure 1) led to the recognition of CI-AKI as the most important complication of iodinated RCM administration. Although contrast enhanced X-ray is the most common indication of RCM use (Figure 1), percutaneous coronary angiography (in the USA: 1.4–1.3 million/year between 1997 and 2010 [12]) is the primary cause of CI-AKI [4, 5]. Although hydration is considered to be the most effective preventive measure [13, 14], CI-AKI may develop in 3–25% of patients despite appropriate hydration [15] and further preventive measures such as antioxidants [2, 16] or statins [4, 17].…”

Section: Introductionmentioning

confidence: 99%

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Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models

Kiss

Hamar

2016

BioMed Research International

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Contrast-induced acute kidney injury (CI-AKI) can occur in 3–25% of patients receiving radiocontrast material (RCM) despite appropriate preventive measures. Often patients with an atherosclerotic vasculature have to receive large doses of RCM. Thus, animal studies to uncover the exact pathomechanism of CI-AKI are needed. Sensitive and specific histologic end-points are lacking; thus in the present review we summarize the histologic appearance of different rodent models of CI-AKI. Single injection of RCM causes overt renal damage only in rabbits. Rats and mice need an additional insult to the kidney to establish a clinically manifest CI-AKI. In this review we demonstrate that the concentrating ability of the kidney may be responsible for species differences in sensitivity to CI-AKI. The most commonly held theory about the pathomechanism of CI-AKI is tubular cell injury due to medullary hypoxia. Thus, the most common additional insult in rats and mice is some kind of ischemia. The histologic appearance is tubular epithelial cell (TEC) damage; however severe TEC damage is only seen if RCM is combined by additional ischemia. TEC vacuolization is the first sign of CI-AKI, as it is a consequence of RCM pinocytosis and lysosomal fusion; however it is not sensitive as it does not correlate with renal function and is not specific as other forms of TEC damage also cause vacuolization. In conclusion, histopathology alone is insufficient and functional parameters and molecular biomarkers are needed to closely monitor CI-AKI in rodent experiments.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models

Kiss

Hamar

2016

BioMed Research International

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“…Recently, several randomized trials reported that pretreatment statin therapy, in particular strong statins, modestly reduces the incidence of Contrast-Induced Acute Kidney Injury in addition to lowering lipid levels in patients undergoing coronary angiography [27,28]. However, there were no significant relationships between CIN incidences and the presence or absence of pretreatment statin in the present study.…”

Section: Discussionmentioning

confidence: 65%

Coronary artery calcification scores improve contrast-induced nephropathy risk assessment in chronic kidney disease patients

et al. 2016

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“…[25][26][27][28][29] Perhaps this could be due to differences in AKI risk profiles among patients who undergo vascular surgery procedures or the specific drug or dose delivered. Additionally, our study was likely underpowered to detect these differences.…”

Section: Discussionmentioning

confidence: 99%

Vascular Surgery Kidney Injury Predictive Score: A Historical Cohort Study

Kashani

Steuernagle

Akhoundi³

et al. 2015

Journal of Cardiothoracic and Vascular Anesthesia

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Meta-Analysis on Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography

Cited by 36 publications

References 23 publications

Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models

Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models

Coronary artery calcification scores improve contrast-induced nephropathy risk assessment in chronic kidney disease patients

Vascular Surgery Kidney Injury Predictive Score: A Historical Cohort Study

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