Meta-analysis study of glutathione-S-transferases (GSTM1,GSTP1, andGSTT1) gene polymorphisms and risk of acute myeloid leukemia

Abstract

To investigate the association of glutathione-S-transferase (GST) polymorphisms with the risk of acute myeloid leukemia (AML), a meta-analysis of case-control studies published between 1998 and 2009 was performed. Pooled odds ratios (ORs) were assessed using both fixed- and random-effects models. Heterogeneity across studies was calculated, and funnel plots were constructed to test for publication bias. Overall, the random-effects OR with GSTM1 null genotype, GSTP1 Val105 allele and GSTT1 null genotype were 1.30 (95% confidence intervals (CI) 1.04-1.62, p = 0.018), 1.03 (95% CI 0.80-1.33, p = 0.80) and 1.24 (95% CI 0.98-1.58, p = 0.06), respectively. Statistically, significant increased risk of AML was observed with GSTM1 while borderline significance was seen with GSTT1 null genotypes. However, fixed-effects model showed significant risk of AML in the presence of null genotypes of GSTM1 and GSTT1(p < 0.05). Significant heterogeneity was found between studies relating to GSTP1 (p = 0.162), however, no heterogeneity was seen in studies that evaluated GSTM1 (Q-value = 44; I(2) = 70.9; p-value < 0.01]; and GSTT1 (Q-value = 26.03; I(2) = 57.74; p-value < 0.01] polymorphisms. From the limited studies on the association of GSTP1 with risk of AML, the role of this gene cannot be ascertained fully. Significant association of these three genes with risk of AML must be evaluated further with respect to population, smoking, eating habits, ethnicity, and race.

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

“…Sample size plays an important role in predicting the association between genotypes and cancer risk in case-control studies. Therefore, the inclusion of studies with very small samples may lead to overestimation of the true association (Das et al, 2009). The results of meta-analyses that are based on relatively small numbers of studies should be interpreted with caution.…”

“…They also found a discrepancy in the A allele frequency in children of different races: 43% in Caucasians, 21% in African Americans, and 41% in Hispanics. Furthermore, infection with hepatitis B virus and/or hepatitis C virus, cirrhosis, male gender, concurrent alcohol use, aflatoxin B1 intake, and multiple based variants (Nissen and Martin, 2002;Chen and Chen, 2002;Das et al, 2009) were found to be risk factors for hepatocellular carcinoma in their study.…”

Risk Effects of GST Gene Polymorphisms in Patients with Acute Myeloid Leukemia: A Prospective Study

“…Numbers of published studies have focused on GSTM1, GSTTI and GSTP1 genetic variation with respect to various cancers. A few studies have shown that significant association of GST polymorphisms with AML, and the results are contradictory (Crump et al, 2000;Naoe et al, 2000;Rollinson et al, 2000;D'Alo et al, 2004;Seedhouse et al, 2004;Taspinar et al, 2008;Das et al, 2009;Mandegary et al, 2011). But there is no study reported their association with AML in Chinese population.…”

Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

“…However, several new studies with more data have been published since 2005. What's more, some previous meta-analysis studies about the association between GST polymorphisms and acute leukemia risk just focused on Childhood acute leukemia (Tang et al, 2013) or one of the types of acute leukemia (Das et al, 2009;Xu et al, 2013). Therefore, to derive a more precise estimation of the association in Asians, with big sample size, we performed a meta-analysis of 23 studies including 3504 cases and 4876 controls.…”