Meta-analytic investigations of common and distinct grey matter alterations in youths and adults with obsessive-compulsive disorder

Hu, Xinyu; Du, Mingying; Chen, Lizhou; Li, Lei; Zhou, Ming; Zhang, Lianqing; Liu, Qi; Lu, Lu; Mreedha, Kunal; Huang, Xiaoqi; Gong, Qiyong

doi:10.1016/j.neubiorev.2017.04.012

Cited by 63 publications

(51 citation statements)

References 101 publications

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“…Structural MRI often detects morphological abnormality or provides radiomic features. Although many works have reported significant volumetric differences between patients and healthy controls (Gilbert et al, ; Hu et al, ; Peng et al, ), they focus on local volumetric variability and neglect the integrity of the brain. Functional MRI measures brain activity based on blood‐oxygen‐level‐dependent level (BOLD) signals.…”

Section: Introductionmentioning

confidence: 99%

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Xing

Jin

et al. 2020

Brain and Behavior

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Object: Obsessive-compulsive disorder (OCD) is a mental disease in which people experience uncontrollable and repetitive thoughts or behaviors. Clinical diagnosis of OCD is achieved by using neuropsychological assessment metrics, which are often subjectively affected by psychologists and patients. In this study, we propose a classification model for OCD diagnosis using functional MR images.Methods: Using functional connectivity (FC) matrices calculated from brain region of interest (ROI) pairs, a novel Riemann Kernel principal component analysis (PCA) model is employed for feature extraction, which preserves the topological information in the FC matrices. Hierarchical features are then fed into an ensemble classifier based on the XGBoost algorithm. Finally, decisive features extracted during classification are used to investigate the brain FC variations between patients with OCD and healthy controls. Results:The proposed algorithm yielded a classification accuracy of 91.8%.Additionally, the well-known cortico-striatal-thalamic-cortical (CSTC) circuit and cerebellum were found as highly related regions with OCD. To further analyze the cerebellar-related function in OCD, we demarcated cerebellum into three subregions according to their anatomical and functional property. Using these three functional

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Section: Introductionmentioning

confidence: 99%

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Xing

Jin

et al. 2020

Brain and Behavior

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“…The dACC has repeatedly been implicated in the pathogenesis of OCD, 14 is directly associated with performance monitoring, 15,17 and shows volumetric reductions in OCD samples across metaanalyses and mega-analyses. 32,33,46 In our contribution to this literature, we demonstrate an association between reduced dACC volume in childhood and a theorized indicator of performance monitoring. We conjecture that these volumetric reductions underlie the emergence of OCD.…”

Section: Discussionmentioning

confidence: 64%

Associations of Observed Performance Monitoring During Preschool With Obsessive-Compulsive Disorder and Anterior Cingulate Cortex Volume Over 12 Years

et al. 2018

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“…We found two meta-analyses of voxel-based morphometry (VBM) analysis with magnetic resonance imaging (MRI) in OCD patients. 16,17 For TS, the query was ''Tourette AND MRI,'' yielding 293 results, of which 11 were ultimately selected. For TTM, our query was ''(TTM or trichotillomania) AND MRI,'' which yielded 55 results; nine were selected for inclusion (Table 4).…”

Section: Imagingmentioning

confidence: 99%

“…When TTM, TS, and OCD imaging studies 16,17,92,[118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133][134][135][136] were compared (Table 4), striatal abnormalities were found in the three disorders. No other common abnormality is found in OCD and TTM (Table 4).…”

Section: Imaging Studiesmentioning

confidence: 99%

“…In imaging studies of TS and TTM, 122,129 increased precentral gyrus volume has been reported in both disorders (since the supplementary motor area [SMA] is part of the precentral gyrus), not in OCD (Table 4). 16,17 There is evidence that the SMA is involved in the neurobiology of tics 137 ; hence, the finding of SMA abnormalities in both TS and TTM imaging studies could suggest a neurobiological relationship between TTM and TS. Unfortunately, it is difficult to reach any definitive conclusion, as meta-analyses of VBM studies in TTM and TS are still lacking; nonetheless, the current data seem to favor a closer relationship between TTM and TS than between TTM and OCD.…”

Section: Imaging Studiesmentioning

confidence: 99%

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Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder

Lamothe

Baleyte

Mallet

et al. 2020

Braz. J. Psychiatry

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Objective: Trichotillomania (TTM) is characterized by the pulling out of one's hair. TTM was classified as an impulse control disorder in DSM-IV, but is now classified in the obsessive-compulsive related disorders section of DSM-5. Classification for TTM remains an open question, especially considering its impact on treatment of the disorder. In this review, we questioned the relation of TTM to tic disorder and obsessive-compulsive disorder (OCD). Method: We reviewed relevant MEDLINE-indexed articles on clinical, neuropsychological, neurobiological, and therapeutic aspects of trichotillomania, OCD, and tic disorders. Results: Our review found a closer relationship between TTM and tic disorder from neurobiological (especially imaging) and therapeutic standpoints. Conclusion: We sought to challenge the DSM-5 classification of TTM and to compare TTM with both OCD and tic disorder. Some discrepancies between TTM and tic disorders notwithstanding, several arguments are in favor of a closer relationship between these two disorders than between TTM and OCD, especially when considering implications for therapy. This consideration is essential for patients.

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Meta-analytic investigations of common and distinct grey matter alterations in youths and adults with obsessive-compulsive disorder

Cited by 63 publications

References 101 publications

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

Associations of Observed Performance Monitoring During Preschool With Obsessive-Compulsive Disorder and Anterior Cingulate Cortex Volume Over 12 Years

Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder

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