Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype

Zaki, Moushira Erfan; Kholoussi, Shams; Ismail, Somaia; Raouf, Haiam Abdel; Helwa, Iman; Hassan, Nayera E.; Youness, Eman R.; Mohamed, Nadia A.; Kamal, Sanaa; Yousef, Walaa; Shaker, Mohamed E.; Ezzat, Wafaa M.; Elhosary, Yasser A.; Saleh, Omnia; Gammal, Mona El; El-Bassyouni, Hala T.; Ismail, Samira; Bibars, Mamdouh; Azmy, Osama

doi:10.1016/j.ejmhg.2015.05.007

Cited by 2 publications

(2 citation statements)

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“…In addition, BMI, WHR and waist circumference were known as three important identifiers of PCOS patients (31). Additionally, another study demonstrated that PCOS patients demonstrate the most prevalent MS components such as central obesity, decreased HDL-C, and increased TG, BP and fasting glucose levels, which was consistent with our results (32). Melatonin is the essential hormone secreted by the pineal gland in both humans and mammals and plays a critical part in regulating circadian rhythm, sleep and reproduction (33).…”

Section: Discussionsupporting

confidence: 92%

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

Kou

Wang

et al. 2019

Mol Med Report

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Polycystic ovary syndrome (PCOS) is a condition in which a woman's levels of the sex hormones (estrogen and progesterone) are out of balance, leading to the growth of ovarian cysts. PCOS can affect the menstrual cycle, fertility, cardiac function and even appearance of women. Therefore, we aimed to explore the genetic polymorphism of the melatonin receptors 1A and 1B in obese patients with PCOS to identify a new theoretical basis for its treatment. Patients presenting with PCOS (n=359) were enrolled and classified into an obese OB-PCOS group [body mass index (BMI) of PCOS patients ≥25 kg/m 2 ] or a nonobese NOB-PCOS group, and 215 oviduct infertile patients who experienced normal ovulation were used as the control group. All baseline characteristics, endocrine hormone levels, lipid and glucose metabolism, and insulin indices were measured. The genotypes of rs2119882 within the MTNR1A gene and of rs10830963 within the MTNR1B gene were determined by PCR-RFLP; the genotype frequency and the difference in the distribution of allele frequency were compared. For rs2119882, C allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS, and C allele carriers with PCOS had an increased risk of developing OB-PCOS. For rs10830963, G allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS. The TT genotype in rs2119882 and the CC genotype in rs10830963 were protective factors for OB-PCOS, and increased levels of LH, testosterone, and estradiol and abnormal menstruation were key risk factors for PCOS. Furthermore, the TT genotype at the rs2119882 site was the key protective factor for OB-PCOS patients. Our study found that MTNR1A rs2119882 and MTNR1B rs10830963 could increase the risk for PCOS and cause glycolipid metabolism disorder in PCOS patients.

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Section: Discussionsupporting

confidence: 92%

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

Kou

Wang

et al. 2019

Mol Med Report

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show abstract

“…Skin-fold thickness was measured in all subjects at the biceps, triceps, subscapular, supra-iliac, and abdominal areas using Holtain caliper then, the sum of skin folds was calculated. A full description of the anthropometric measurements has been reported elsewhere (Zaki et al, 2015[ 33 ]). All measurements were obtained according to standardized equipment and following the recommendations of the International Biological Program (Hiernaux and Tanner, 1969[ 12 ]).…”

Section: Methodsmentioning

confidence: 99%

Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women

Zaki

Kamal

Kholousi

et al. 2017

EXCLI Journal; 16:Doc973; ISSN 1611-2156

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Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype

Cited by 2 publications

References 50 publications

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women

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