Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a condition in which a woman's levels of the sex hormones (estrogen and progesterone) are out of balance, leading to the growth of ovarian cysts. PCOS can affect the menstrual cycle, fertility, cardiac function and even appearance of women. Therefore, we aimed to explore the genetic polymorphism of the melatonin receptors 1A and 1B in obese patients with PCOS to identify a new theoretical basis for its treatment. Patients presenting with PCOS (n=359) were enrolled and classified into an obese OB-PCOS group [body mass index (BMI) of PCOS patients ≥25 kg/m 2 ] or a nonobese NOB-PCOS group, and 215 oviduct infertile patients who experienced normal ovulation were used as the control group. All baseline characteristics, endocrine hormone levels, lipid and glucose metabolism, and insulin indices were measured. The genotypes of rs2119882 within the MTNR1A gene and of rs10830963 within the MTNR1B gene were determined by PCR-RFLP; the genotype frequency and the difference in the distribution of allele frequency were compared. For rs2119882, C allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS, and C allele carriers with PCOS had an increased risk of developing OB-PCOS. For rs10830963, G allele carriers who were not diagnosed with PCOS had an increased risk of developing PCOS. The TT genotype in rs2119882 and the CC genotype in rs10830963 were protective factors for OB-PCOS, and increased levels of LH, testosterone, and estradiol and abnormal menstruation were key risk factors for PCOS. Furthermore, the TT genotype at the rs2119882 site was the key protective factor for OB-PCOS patients. Our study found that MTNR1A rs2119882 and MTNR1B rs10830963 could increase the risk for PCOS and cause glycolipid metabolism disorder in PCOS patients.

Association between serum melatonin and skin aging in an urban population of Mongolia

“…We compared the level of obesity and serum melatonin levels. Our study revealed that people with obesity grades I and II have low melatonin levels, but the differences were not statistically significant …”

“…In another study, researchers sought to study the genetic polymorphism of melatonin receptors 1A and 1B in obese patients with polycystic ovarian syndrome (PCOS) to identify a new theoretical basis for its treatment. As a result, the study provided evidence of the relationship between the polymorphism of the melatonin receptor genes and lipid metabolism disorders in patients with PCOS …”

Association of single nucleotide polymorphisms in the RAB5B gene 3′UTR region with polycystic ovary syndrome in Chinese Han women

“…Its etiology and pathogenesis are related not only to genetic factors, but also to environmental factors [3–6]. Recent studies have shown that the etiology of PCOS is likely correlated with genes involved in androgen elevated, insulin resistance and insulin-regulating genes, as well as those involved in metabolism, steroid hormones and glandular hormone biosynthesis [7–10].…”

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

“…In a recent study, evidence has been provided showing the relationship between rs2119882 and rs10830963 melatonin receptor polymorphism and lipid metabolism disorder in PCOS patients, highlighting the importance of the therapeutic and protective effects of melatonin and its metabolites [ 16 ].…”