Metabolic alteration in healthy men with first degree type 2 diabetic relatives

Pauer, József; Fék, Attila; Buday, Barbara; Literáti-Nagy, Botond; Pach, Péter; Vitai, Márta; Péterfai, Éva; Korányi, László

doi:10.1556/oh.2013.29538

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…This study demonstrated significant reduction in adiponectin level in pre-diabetic and diabetic participants when compared with control group. Similar observation was documented in the study of Shrestha S et al [11], Pauer J et al [13] and Jiang Y et al [14].…”

Section: Discussionsupporting

confidence: 89%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control. Aim: To study the effect of glycemic status on inflammatory markers in pre-diabetes and diabetes. Methods: This study included 300 subjects divided into 3 groups; Control: 100, Pre-diabetes: 100 patients and Diabetes: 100 patients. Basic details of all the participants like age and gender were recorded and laboratory investigations like fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), IL-6, CRP, fibrinogen, uric acid and adiponectin were conducted. Results: Compared to controls, the levels FBS, HbA1c, IL-6, CRP, fibrinogen and uric acid were elevated and adiponectin was decreased in pre-diabetes and diabetes. The inflammatory parameters (IL-6, CRP, fibrinogen, uric acid and adiponectin) were significantly correlated with glycemic parameters (FBS, HbA1c) in diabetes, i.e. r=0.28, r=0.55, r=0.2, r=0.48 and r=-0.4 respectively in case of FBS and r=-0.39, r=0.48, r=0.21, r=0.33 and r=-0.53 respectively for HbA1c. Similarly, in pre-diabetes, FBS correlated significantly with adiponectin (r=-0.19), fibrinogen (r=0.29) and uric acid (r=0.18) while that with HbA1c was significant with adiponectin (r=-0.31), IL-6 (r=0.25), CRP (r=0.21) and fibrinogen (r=0.3). Conclusion:The strong correlations observed between glycemic control parameters and inflammation parameters in prediabetes and diabetes suggested the crucial involvement of inflammation in the diabetes development. So better control of glycemia can cause significant reduction in inflammation and arrest the health burden.

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Section: Discussionsupporting

confidence: 89%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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“…The same results were shown in other studies [37][38][39] . In addition, several case-control studies by Pauer et al 40 reported that prediabetes are associated with lower circulating adiponectin concentrations in patients with insulin resistance and type 2 diabetes [41][42][43] , as well as in patients with prediabetic conditions 25,[44][45][46] .…”

Section: Discussionmentioning

confidence: 99%

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

Lai

Lin

Xing

et al. 2015

J of Diabetes Invest

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Aims/IntroductionAdiponectin has been proposed to have an essential role in the regulation of insulin sensitivity and metabolism, but previous studies on levels of adiponectin in prediabetes remain inconsistent. The present study aimed to assess the differences of adiponectin levels between prediabetes patients and healthy controls by carrying out a meta-analysis.Materials and MethodsWe carried out a systematic literature search of PubMed, EMBASE, and other databases for case–control studies and cohort studies measuring adiponectin levels in serum or plasma from prediabetes patients and healthy controls. The pooled weighted mean difference (WMD) and 95% confidence interval (CI) were used to estimate the association between adiponectin levels and prediabetes.ResultsThree cohort studies and 15 case–control studies with a total of 41,841 participants were included in the meta-analysis. The results showed that circulating adiponectin levels in prediabetes patients were significantly lower than that of healthy controls (WMD –1.694 μg/mL; 95% CI –2.151, –1.237; P < 0.001). Subgroup analysis showed more significant differences between prediabetes patients and healthy controls when the ratio of the homeostatic model assessment of insulin resistance was >2.12 (WMD −2.95 μg/mL; 95% CI –4.103, –1.806; P < 0.001) and average age was >60 years (WMD −2.20 μg/mL; 95% CI –3.207, –1.201; P < 0.001). Additionally, WMD in adiponectin showed a trend of direct correlation in subgroups of homeostatic model assessment of insulin resistance ratio, body mass index and age.ConclusionsThe present meta-analysis supports adiponectin levels in prediabetes patients being lower than that of healthy controls,indicating that the level of circulating adiponectin decreases before the onset of diabetes.

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Metabolic alteration in healthy men with first degree type 2 diabetic relatives

Cited by 2 publications

References 31 publications

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Association between the level of circulating adiponectin and prediabetes: A meta‐analysis

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