Metabolic and behavioural effects of prenatal exposure to non-nutritive sweeteners: A systematic review and meta-analysis of rodent models

Morahan, Heidi; Leenaars, Cathalijn; Boakes, Robert A.; Rooney, Kieron

doi:10.1016/j.physbeh.2019.112696

Cited by 19 publications

(18 citation statements)

References 65 publications

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“…Archibald et al 18 reviewed the evidence for early life LCS exposure and the developmental origins of childhood obesity from human and rodent studies and concluded that while some observational studies suggest children consuming LCS have increased obesity risk, fewer studies have examined prenatal LCS exposure. In rats, increased body weight, fasting glucose and impaired learning performance were seen in males exposed to high doses of aspartame (50 mg/kg) beginning in utero and continuing with chronic direct postnatal exposure19; however, this remains controversial 20. Recently, Olivier-Van Stichelen and colleagues found that prenatal exposure to acesulfame potassium and sucralose altered offspring microbiota at 20 days of age in mice 9.…”

Section: Introductionmentioning

confidence: 99%

“…In rats, increased body weight, fasting glucose and impaired learning performance were seen in males exposed to high doses of aspartame (50 mg/kg) beginning in utero and continuing with chronic direct postnatal exposure 19 ; however, this remains controversial. 20 Recently, Olivier-Van Stichelen and colleagues found that prenatal exposure to acesulfame potassium and sucralose altered offspring microbiota at 20 days of age in mice. 9 Therefore, our objective was to examine whether maternal consumption of low-dose aspartame or stevia during pregnancy and lactation alters glucose tolerance and gut microbiota in pregnant and lactating dams.…”

Section: Introductionmentioning

confidence: 99%

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Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring

Nettleton

Cho

Klančič

et al. 2020

Gut

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ObjectiveWe examined the impact of maternal low-dose aspartame and stevia consumption on adiposity, glucose tolerance, gut microbiota and mesolimbic pathway in obese dams and their offspring.DesignFollowing obesity induction, female Sprague-Dawley rats were allocated during pregnancy and lactation to: (1) high fat/sucrose diet (HFS) +water (obese-WTR); (2) HFS +aspartame (obese-APM; 5–7 mg/kg/day); (3) HFS +stevia (obese-STV; 2–3 mg/kg/day). Offspring were weaned onto control diet and water and followed until 18 weeks. Gut microbiota and metabolic outcomes were measured in dams and offspring. Cecal matter from offspring at weaning was used for faecal microbiota transplant (FMT) into germ-free (GF) mice.ResultsMaternal APM and STV intake with a HFS diet increased body fat in offspring at weaning and body weight long-term with APM. Maternal APM/HFS consumption impaired glucose tolerance in male offspring at age 8 weeks and both APM and STV altered faecal microbiota in dams and offspring. Maternal obesity/HFS diet affected offspring adiposity and glucose tolerance more so than maternal LCS consumption at age 12 and 18 weeks. APM and STV altered expression of genes in the mesolimbic reward system that may promote consumption of a palatable diet. GF mice receiving an FMT from obese-APM and obese-STV offspring had greater weight gain and body fat and impaired glucose tolerance compared with obese-WTR.ConclusionMaternal low-calorie sweetener consumption alongside HFS may disrupt weight regulation, glucose control and gut microbiota in dams and their offspring most notably in early life despite no direct low-calorie sweetener consumption by offspring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring

Nettleton

Cho

Klančič

et al. 2020

Gut

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“…Based on discoveries in rat models, litter size was not influenced in utero in NNS introduction. 42 Anyway, constant NNS introduction during lactation period showed a noteworthy decrease in body weight at weaning yet not during childbirth. 31,37,[42][43][44] Child's body weight at adulthood was likewise diminished when exposed to NNS during pregnancy and lactation.…”

Section: Birth Weight and Weight Gainmentioning

confidence: 93%

“…42 Anyway, constant NNS introduction during lactation period showed a noteworthy decrease in body weight at weaning yet not during childbirth. 31,37,[42][43][44] Child's body weight at adulthood was likewise diminished when exposed to NNS during pregnancy and lactation. 37,[45][46][47][48] A couple of studies uncovered weight gain from birth to adulthood, following in utero NNS exposure.…”

Section: Birth Weight and Weight Gainmentioning

confidence: 93%

Consumption of Nonnutritive Sweeteners during Pregnancy

Malhotra¹,

Sahoo²,

Garg³

et al. 2020

Journal of South Asian Federation of Obstetrics and Gynaecology

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Studies have indicated that practically all pregnant ladies in the world have certain degree of synthetic compounds in their body, for example, phthalates, bisphenol A, flame retardant, tobacco, pesticides, lead, polychlorinated-biphenyl, and mercury. 1,2 These synthetic compounds have been related to preterm birth, innate peculiarities, and neuroformative issues. During early fetal advancement, even gentle introduction to such poisonous synthetic concoctions can have enduring negative impacts prompting development of infection from youth to adulthood. 1,3 Among developing food additive substances that are raising concerns, nonnutritive sugars (NNS) have been tested in kids, grown-ups, and pregnant women. 4,5 nonnutrItIve SweetenerS a n d nonnutrItIve SugarS regulatIon a n d labelIng Nonnutritive sugars (NNS) are zero or low-calorie options in contrast to nutritive sugars. They are generally utilized in nourishments and drinks. 6 Right now, there are no rules for NNS utilization in pregnancy, despite collecting proof of unfriendly impacts, after their utilization, in creature models. The American Heart Association suggest restricting included sugar by supplanting it with without sugar choices containing NNS. NNS endorsed for utilization in the United States are Sucralose, Acesulfame-K, Aspartame, Saccharin, and Stevioside. 4 Accordingly, NNS use has been accounted for to have expanded from 8.7% to 25.1% in kids and from 26.9% to 41.4% of grown-ups from 1999 to 2000 to 2009 to 2012, with higher utilization in females than males. 7 The FDA has approved six NNS and has given ADI (Acceptable Daily Intake) values for each. 8 The two difficulties that purchasers are looking after the endorsement by FDA are that initially, NNS amount is not uncovered per serving on huge numbers of the foods and refreshments, and furthermore, NNS is additionally being found in clueless items, for example, 'no-sugar included' or 'decreased sugar' items, making it hard for buyers to maintain a strategic distance from NNS. Sugar items with NNS answers to bring down rewards in the sensory system contrasted with sweet nourishments or drinks. 9 NNS binds to sweet taste receptors that are found on the tongue as well as in the lungs, digestion tracts, fat tissues, bones, and testicles. 10,11 In utero Exposure and Breastmilk Studies have shown that sucralose can be found in the urine of the newborns proposing in utero transmission through cord blood. 31 Acesulfame-K was found in amniotic liquids and urine of fetus in 1,

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“…Batas beban yang dapat diangkat oleh manusia tanpa menimbulkan cedera meskipun pekerjaan tersebut dilakukan secara berulang-ulang dalam durasi kerja tertentu (misal 8 jam sehari) dan dalam jangka waktu yang cukup lama. rumus untuk menghitung beban yang disarankan menurut NIOSH untuk diangkat seorang pekerja adalah [9], [14], [26], [27] : Hasil dan Pembahasan Data diambil aktifitas angkat beban es balok seberat 27 kg secara manual yang dilakukan oleh para pekerja di pabrik penggolahan es balok. Pekerja yang diamati sebanyak 8 orang, data yang diambil meliputi berat badan pekerja, berat beban yang diangkat, panjang segmen tubuh panjang telapak tangan, lengan atas, lengan bawah, punggung, sudut inklinasi perut terhadap horizontal dan sudut inklinasi paha terhadap horizontal.…”

Section: Lamanya Waktu Atau Durasi Dalam Melakukan Aktivitas Pemindahunclassified

Analisis Postur Kerja Manual Material Handling Menggunakan Biomekanika dan Niosh

Sanjaya

Wirawan

Adenan

2018

jatiunik. jurnal. ilm. teknik. manaj. industri.

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Kerja atau aktivitas merupakan salah satu kegiatan manusia yang tidak dapat dihindarkan lagi. Salah satu aktivitas tersebut adalah pemindahan barang, proses pemindahan barang terjadi baik diperusahaan maupun pekerja yang berada diluar perusahaan. Aktivitas pemindahan yang terjadi pada pekerja bongkar es balok terjadi secara manual. Aktifitas pengangkatan secara membungkuk yang disebabkan adanya pembebanan yang terlalu berat menyebabkan cedera tulang belakang dan gangguan otot lainnya (musculoskeletal disorder). Selain itu aktifitas pemindahan barang juga perlu diperhatikan guna meningkatkan kesehatan dan keselamatan kerja. Pada hasil penelitian Berdasarkan perhitungan momen gaya rata-rata adalah 74425,72, hal ini akan membuat sakit pada tulang belakang sehingga dalam waktu tertentu tubuh akan berubah menjadi membungkuk. Nilai konsumsi energi rata-rata adalah 3,6, hal ini menunjukkan konsumsi energi oleh para pekerja termasuk kategori moderat. Untuk nilai RWL rata-rata 16,42 kg dan nilai (LI) dengan massa beban 27 kg nilai LI rata-rata adalah 1,63, nilai tersebut sangat beresiko menyebabkan cedera tulang belakang L5/S1. Setelah dilakukan usulan perbaikan sistem kerja pada RWL dan LI mendapatkan hasil nilai RWL sebesar 40,67 dan LI sebesar 0,6, nilai LI setelah usulan sudah tidak menimbulkan cidera pada ruas tulang belakang L5/S1.Kata kunci : Biomekanika, Lifting Index (LI), Manual Material Hadling, Recommended Weight Limit (RWL).

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Metabolic and behavioural effects of prenatal exposure to non-nutritive sweeteners: A systematic review and meta-analysis of rodent models

Cited by 19 publications

References 65 publications

Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring

Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring

Consumption of Nonnutritive Sweeteners during Pregnancy

Analisis Postur Kerja Manual Material Handling Menggunakan Biomekanika dan Niosh

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