2009
DOI: 10.1111/j.1365-2036.2008.03896.x
|View full text |Cite
|
Sign up to set email alerts
|

Metabolic and histological features of non‐alcoholic fatty liver disease patients with different serum alanine aminotransferase levels

Abstract: SUMMARY BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in affluent countries. Serum alanine aminotransferase (ALT) level is commonly performed to monitor NAFLD patients, but its clinical relevance is unclear.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

7
90
0
1

Year Published

2010
2010
2020
2020

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 114 publications
(98 citation statements)
references
References 38 publications
7
90
0
1
Order By: Relevance
“…It is well-known that aminotransferase levels in many (if not most) patients with NASH are often normal or only slightly elevated [12,14,15]. This was also true in our cohort, where only 23.1% of NASH subjects had elevated ALT.…”
Section: Discussionsupporting
confidence: 71%
“…It is well-known that aminotransferase levels in many (if not most) patients with NASH are often normal or only slightly elevated [12,14,15]. This was also true in our cohort, where only 23.1% of NASH subjects had elevated ALT.…”
Section: Discussionsupporting
confidence: 71%
“…However, ALT values do not correlate well with the severity of liver injury in human NAFLD. 35,36 Similar to that in patients with NAFLD but that inunlike viral or drug-induced hepatitis, the ALT level in this rabbit model remained unchanged, but the mechanism remains unknown and should be clarified in future research.…”
Section: Discussionsupporting
confidence: 57%
“…at 0.5 Â upper limit of healthy population reference range) might still be associated with significant histological abnormalities in the liver. 16 Low-density lipoprotein cholesterol (LDL-C) concentrations was calculated using the Friedewald formula for TG , 4.5 mmol/L. 17 Insulin resistance (IR) was calculated from the Homeostasis Model Assessment (HOMA) where HOMA-IR ¼ fasting plasma glucose (FPG) (mmol/L) Â fasting insulin (mU/mL) 4 22.5 and insulin secretion, by…”
Section: Laboratory Measurementsmentioning
confidence: 99%