Metabolic and Nutritional Aspects in Paediatric Patients with Klinefelter Syndrome: A Narrative Review

Mameli, Chiara; Fiore, Giulia; Sangiorgio, Arianna; Agostinelli, Marta; Zichichi, Giulia; Zuccotti, Gian Vincenzo; Verduci, Elvira

doi:10.3390/nu14102107

Cited by 4 publications

(5 citation statements)

References 70 publications

(177 reference statements)

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“…On the whole, the patients with psoriasis should to be recommended to lose weight and detect the comorbidities early. 43 In our study of metabolic pathway analyses, we found that the pathway of synthesis and degradation of ketone bodies was the most significant. The result was consistent with previous research that ketone bodies play an essential role in psoriasis.…”

Section: Discussionmentioning

confidence: 83%

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Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis

Wang,

Lin,

Chen

et al. 2024

Skin Research and Technology

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BackgroundPsoriasis is a chronic inflammatory disease that causes significant disability. However, little is known about the underlying metabolic mechanisms of psoriasis. Our study aims to investigate the causality of 975 blood metabolites with the risk of psoriasis.Materials and MethodsWe mainly applied genetic analysis to explore the possible associations between 975 blood metabolites and psoriasis. The inverse variance weighted (IVW) method was used as the primary analysis to assess the possible association of blood metabolites with psoriasis. Moreover, generalized summary‐data‐based Mendelian randomization (GSMR) was used as a supplementary analysis. In addition, linkage disequilibrium score regression (LDSC) was used to investigate their genetic correction further. Metabolic pathway analysis of the most suggested metabolites was also performed using MetaboAnalyst 5.0.ResultsIn our primary analysis, 17 metabolites, including unsaturated fatty acids, phospholipids, and triglycerides traits, were selected as potential factors in psoriasis, with odd ratios (OR) ranging from 0.986 to 1.01. The GSMR method confirmed the above results (β = 0.001, p < 0.05). LDSC analysis mainly suggested the genetic correlation of psoriasis with genetic correlations (rg) from 0.088 to 0.155. Based on the selected metabolites, metabolic pathway analysis suggested seven metabolic pathways including ketone body that may be prominent pathways for metabolites in psoriasis.ConclusionOur study supports the causal role of unsaturated fatty acid properties and lipid traits with psoriasis. These properties may be regulated by the ketone body metabolic pathway.

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Section: Discussionmentioning

confidence: 83%

“…Apart from blood metabolites, other possible targeted microbiotas are supposed to be studied further in psoriasis and metabolic syndrome via genomics and metabolomics. On the whole, the patients with psoriasis should to be recommended to lose weight and detect the comorbidities early 43 …”

Section: Discussionmentioning

confidence: 99%

Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis

Wang,

Lin,

Chen

et al. 2024

Skin Research and Technology

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“…Regarding potential confounding effects of diet in the present study, no significant differences regarding daily total energy or antioxidant vitamin intake were found between the intervention and control groups. Surprisingly, a previous study found that adult patients with PsO had a poor nutritional status, and were at risk of nutrient deficiencies compared to BMI-matched controls without PsO [5]. On reviewing the literature on this population group, it appears that future studies focusing on interventions based on the combination of a healthy anti-inflammatory personalized diet and exercise are urgently required [51].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have emphasized that psoriasis is a systemic disease with multiple comorbidities that extend beyond the skin [2][3][4]. It has been associated with an increased risk for comorbidities, including but not limited to arthritic, psychological, and cardiometabolic conditions [2][3][4][5]. In a more detailed way, the overall pooled prevalence of metabolic syndrome in adult patients with PsO was 32% (95% confidence interval (CI), 0.26-0.38) [6].…”

Section: Introductionmentioning

confidence: 99%

Regular Exercise Improved Fatigue and Musculoskeletal Pain in Young Adult Psoriatic Patients without Psoriatic Arthritis

Diaz,

Rosety,

Armario

et al. 2023

Nutrients

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Fatigue and musculoskeletal pain are also frequent in patients with psoriasis (PsO) without arthritis (PsA). The current study aimed to assess the impact of an intervention program based on aerobic training to reduce fatigue and musculoskeletal pain in patients with PsO without PsA. A total of 118 male patients with PsO volunteered in the current interventional study and were randomly allocated to the experimental (n = 59) or control group (n = 59). The intervention consisted of a 16-week aerobic training program on a treadmill, three sessions per week, consisting of a warm-up, 35–50 min treadmill exercise (increasing 5 min/4 weeks) at a work intensity of 50–65% of peak heart-rate (increasing 5%/4 weeks), and cooling-down. The functional assessment of chronic illness therapy fatigue scale (FACIT-Fatigue), health assessment questionnaire disability index (HAQ-DI), and visual analog scale (VAS) were compared pre and post intervention. Nutritional intake, maximal aerobic power, lipid profile, serum markers of muscle damage, and body composition were also assessed. When compared to baseline, FACIT-Fatigue, HAQ-DI, and VAS scores were significantly improved without increasing markers of muscle damage. Fat mass percentage, lipid profile, and maximal oxygen consumption were also improved. In conclusion, a 16-week aerobic training program at moderate intensity was safe, well tolerated, and effective in psoriatic patients without PsA. Long-term follow-up studies are required to examine whether these promising results may improve clinical outcomes.

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“…Both PsO and AD are chronic inflammatory diseases with systemic manifestations other than skin pathology. Both diseases are related to obesity via the complex influence of proinflammatory cytokines (IL-6, IL-17, TNF-α) and adipokines, leading to cardiometabolic disturbances [4,[22][23][24][25]. However, unlike clear evidence of increased prevalence of cardiometabolic diseases in patients with PsO, results concerning the link between AD and cardiometabolic risk are inconclusive [26].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis

Klisic,

Bakic,

Karanikolic

2023

Antioxidants

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There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive and specific oxidative stress biomarker that could best reflect the existence of one of these disease entities. Methods: Forty patients with PsO and forty patients with AD were consecutively included in this cross-sectional study. Parameters of redox homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) and advanced oxidation protein products (AOPP)] and antioxidants [catalase (CAT) and superoxide dismutase (SOD)] were determined. Results: There was no difference in oxidative stress biomarkers between the PsO and AD group, except for higher CAT activity in the AD group (p < 0.001). Among all examined redox homeostasis biomarkers, ROC analysis showed that only CAT exhibited good diagnostic accuracy (AUC = 0.719) in the discrimination of patients with PsO vs. AD, with 0.436 U/L as the cut-off value of CAT activity. Conclusions: The CAT exhibited good diagnostic accuracy in the discrimination of patients with AD from those with PsO. The obtained results could suggest the importance of the use of antioxidants as a potential therapeutic strategy in the treatment of these two skin inflammatory diseases.

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Metabolic and Nutritional Aspects in Paediatric Patients with Klinefelter Syndrome: A Narrative Review

Cited by 4 publications

References 70 publications

Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis

Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis

Regular Exercise Improved Fatigue and Musculoskeletal Pain in Young Adult Psoriatic Patients without Psoriatic Arthritis

Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis

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