Metabolic assessment of intracranial tuberculomas using 11C-methionine and 18F-FDG PET/CT

D’Souza, Maria; Sharma, Rajnish; Jaimini, Abhinav; Panwar, Puja; Bansal, Abhishek; Tripathi, Madhavi; Varshney, Raunak; Pandey, Santosh Kumar; Mondal, Anupam

doi:10.1097/mnm.0b013e32834f9b14

Cited by 17 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study 3, the standardized uptake value ratio (lesion to contralateral brain area) in both of these conditions was significantly lower (range: 0.3–0.7) than that noted in patients with lymphoma (range: 1.7–3.1) with virtually no overlap of the uptake values. Contrary to this 3, in a recently reported case series studying intracranial tuberculomas 4, a relatively high lesion-to-normal gray matter uptake ratio was observed on both 11 C-methionine (1.8±0.38) and 18 F-FDG scans (1.64±0.26) in all newly diagnosed cases. The investigators concluded that 11 C-methionine, similar to 18 F-FDG, has limited specificity in distinguishing tuberculoma from neoplastic lesions 4.…”

contrasting

confidence: 79%

“…Contrary to this 3, in a recently reported case series studying intracranial tuberculomas 4, a relatively high lesion-to-normal gray matter uptake ratio was observed on both 11 C-methionine (1.8±0.38) and 18 F-FDG scans (1.64±0.26) in all newly diagnosed cases. The investigators concluded that 11 C-methionine, similar to 18 F-FDG, has limited specificity in distinguishing tuberculoma from neoplastic lesions 4.…”

contrasting

confidence: 79%

See 1 more Smart Citation

Ring-enhancing brain lesions, clinical presentation of focal seizures, and inconclusive anatomical neuroimaging features

Basu

2013

Nuclear Medicine Communications

View full text Add to dashboard Cite

contrasting

confidence: 79%

contrasting

confidence: 79%

Ring-enhancing brain lesions, clinical presentation of focal seizures, and inconclusive anatomical neuroimaging features

Basu

2013

Nuclear Medicine Communications

View full text Add to dashboard Cite

“…[21][22][23][24] Other PET Tracers Preliminary data suggest a role for monitoring for other PET tracer such as Ga68 citrate, F18 ethylcholine, and C11 methionine. [107][108][109] In preclinical studies, 68 Ga labeled with triacetylfusarinine C and ferrioxamine E and [ 64 Cu] DOTA labeled Aspergillus fumigatus-specific monoclonal antibody are Aspergillus-specific tracers that may have a role in monitoring infections. 110,111 In TB, a tracer trehalose, a non-mammalian disaccharide is at the very early stage of development and has shown promise in TB imaging.…”

Section: Fdg Monitoring In Other Conditionsmentioning

confidence: 99%

Monitoring Response to Therapy

Sathekge

Ankrah

Lawal

et al. 2018

Seminars in Nuclear Medicine

View full text Add to dashboard Cite

Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging. However, there are currently no clinical criteria or recommended imaging modalities to objectively evaluate the effectiveness of antimicrobial treatment. Therapeutic effectiveness is currently gauged by the patient's subjective clinical response. In this review, we present the current studies for monitoring treatment response, with a focus on Mycobacterium tuberculosis, as it remains a major worldwide cause of morbidity and mortality. The role of molecular imaging in monitoring other infections including spondylodiscitis, infected prosthetic vascular grafts, invasive fungal infections, and a parasitic disease is highlighted. The role of functional imaging in monitoring lipodystrophy associated with highly active antiretroviral therapy for human immunodeficiency virus is considered. We also discuss the key challenges and emerging data in optimizing noninvasive response evaluation.

show abstract

“…Given these results, MET PET appears to be superior to NH 3 PET and FDG PET for detection of tumor lesions. However, increased uptake of these amino acid tracers is not specific as it has been observed in many NNL, including intracranial hemorrhages, cerebral infarctions, multiple sclerosis and brain abscess [16, 24–27]. In this study, MET PET revealed low specificity for brain tumors, as 10 of 23 NNL (6 patients with inflammatory and abscess lesions, 1 demyelination, 2 infarctions and 1 hemorrhage) showed MET uptake positive.…”

Section: Discussionmentioning

confidence: 49%

Diagnostic accuracy of 13N-ammonia PET, 11C-methionine PET and 18F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma

Zhang

et al. 2019

BMC Cancer

View full text Add to dashboard Cite

Background The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13 N-ammonia (NH 3 ), 11 C-methionine (MET) and 18 F-fluorodeoxyglucose (FDG) have been used to assess brain tumors. Our aim was to compare their diagnostic accuracies in patients with suspected cerebral glioma. Methods Ninety patients with suspicion of glioma based on previous CT/MRI, who underwent NH 3 PET, MET PET and FDG PET, were prospectively enrolled in the study. The reference standard was established by histology or clinical and radiological follow-up. Images were interpreted by visual evaluation and semi-quantitative analysis using the lesion-to-normal white matter uptake ratio (L/WM ratio). Results Finally, 30 high-grade gliomas (HGG), 27 low-grade gliomas (LGG), 10 non-glioma tumors and 23 non-neoplastic lesions (NNL) were diagnosed. On visual evaluation, sensitivity and specificity for differentiating tumors from NNL were 62.7% (42/67) and 95.7% (22/23) for NH 3 PET, 94.0% (63/67) and 56.5% (13/23) for MET PET, and 35.8% (24/67) and 65.2% (15/23) for FDG PET. On semi-quantitative analysis, brain tumors showed significantly higher L/WM ratios than NNL both in NH 3 and MET PET (both P < 0.001). The sensitivity, specificity and the area under the curve (AUC) by receiver operating characteristic (ROC) analysis, respectively, were 64.2, 100% and 0.819 for NH 3 ; and 89.6, 69.6% and 0.840 for MET. Besides, the L/WM ratios of NH 3 , MET and FDG PET in HGG all significantly higher than that in LGG (all P < 0.001). The predicted (by ROC) accuracy of the tracers (AUC shown in parentheses) were 86.0% (0.896) for NH 3 , 87.7% (0.928) for MET and 93.0% (0.964) for FDG. While no significant differences in the AUC were seen between them. Conclusion NH 3 PET has remarkably high specificity for the differentiation of brain tumors from NNL, but low sensitivity for the detection of LGG. MET PET was found to be highly useful for detection of brain tumors. However, like FDG, high MET uptake is frequently observed in some NNL. NH 3 , MET and FDG PET all appears to be valuable for evaluating the histological grade of gliomas.

show abstract

Metabolic assessment of intracranial tuberculomas using 11C-methionine and 18F-FDG PET/CT

Cited by 17 publications

References 20 publications

Ring-enhancing brain lesions, clinical presentation of focal seizures, and inconclusive anatomical neuroimaging features

Ring-enhancing brain lesions, clinical presentation of focal seizures, and inconclusive anatomical neuroimaging features

Monitoring Response to Therapy

Diagnostic accuracy of 13N-ammonia PET, 11C-methionine PET and 18F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma

Contact Info

Product

Resources

About