Ring enhancing lesions are a common neurological problem seen in eithergender and in all age groups. Objectives: To determine the clinical presentations and etiologicalfactors in patients with ring enhancing lesion on CT scan brain. Design: Case series study.Period: One year. Setting: Department of medicine, Liaquat University Hospital, Hyderabad.Patients and methods: Subjects of either sex ≥12 years of age, presented with seizures, fever,focal neurological signs and deficit, headache, weight loss and vomiting and had single ormultiple ring enhancing lesions on computed tomography (contrast CT brain film) were enrolledand entered in the study. CT scan brain was advised to evaluate any identified lesion and thencertain specific biochemical tests were also advised to detect the particular existence etiologicalfactor. The data was analyzed in SPSS 16 and the frequency and percentage was calculated.Results: During one year study period, total 50 subjects were detected as ring enhancing lesionon CT scan. The mean age ±SD of the over all population was 28.87±4.84 whereas the meanage ±SD of male and female population was 27.76±6.53 and 30.76±5.83 respectively. Ringenhancing lesions were right sided in 30 patients (60%), on the left side in 15 (30%) and bilaterallesions were identified in 6 subjects (10%) on brain imaging. Majority of the ring enhancinglesions were single 45 (90%) and the parietal lobe was observed as the commonest site. Theheadache, seizures, fever, pyramidal signs and papilledema was identified the common clinicalfeatures whereas the common etiological factors responsible for ring enhancing impression onbrain CT scan were tuberculoma 17(34%), brain tumor 12(24%), metastasis 05(10%) and brainabscess 04(08%). Conclusions: The male population was predominant while the seizure wasobserved as common clinical feature whereas the tuberculoma, brain tumour and metastasisare the common etiological factors responsible for ring enhancing lesion on brain imaging.