Metabolic assessment of recurrent and first renal calcium oxalate stone formers

Çakıroğlu, Basri; Eyyupoglu, Erkan; Hazar, Aydin Ismet; Uyanık, Bekir Sami; Nuhoğlu, Barış

doi:10.4081/aiua.2016.2.101

Cited by 8 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of the promoters include cell membrane lipids (phospholipids, cholesterol, and glycolipids) [ 42 ], calcitriol hormone enhancement via parathyroid hormone stimulation [ 101 ], oxalate, calcium, sodium, cystine, and low urine volume [ 34 ]. Among recurrent stone formers, urinary oxalate excretion was found to be higher, whereas citrate excretion was lower [ 102 ]. Studies indicated that oxalate can increase chloride, sodium, and water reabsorption in the proximal tubule and activate multiple signaling pathways in renal epithelial cells [ 103 ].…”

Section: Mechanisms Of Renal Stone Formationmentioning

confidence: 99%

Kidney Stone Disease: An Update on Current Concepts

Alelign

Petros

2018

Advances in Urology

582

432

View full text Add to dashboard Cite

Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an increasing urological disorder of human health, affecting about 12% of the world population. It has been associated with an increased risk of end-stage renal failure. The etiology of kidney stone is multifactorial. The most common type of kidney stone is calcium oxalate formed at Randall's plaque on the renal papillary surfaces. The mechanism of stone formation is a complex process which results from several physicochemical events including supersaturation, nucleation, growth, aggregation, and retention of urinary stone constituents within tubular cells. These steps are modulated by an imbalance between factors that promote or inhibit urinary crystallization. It is also noted that cellular injury promotes retention of particles on renal papillary surfaces. The exposure of renal epithelial cells to oxalate causes a signaling cascade which leads to apoptosis by p38 mitogen-activated protein kinase pathways. Currently, there is no satisfactory drug to cure and/or prevent kidney stone recurrences. Thus, further understanding of the pathophysiology of kidney stone formation is a research area to manage urolithiasis using new drugs. Therefore, this review has intended to provide a compiled up-to-date information on kidney stone etiology, pathogenesis, and prevention approaches.

show abstract

Section: Mechanisms Of Renal Stone Formationmentioning

confidence: 99%

Kidney Stone Disease: An Update on Current Concepts

Alelign

Petros

2018

Advances in Urology

582

432

View full text Add to dashboard Cite

show abstract

“…[15] Recurrent stone-formers were found to excrete more oxalate from their urine than citrate. [52] Oxalate has been shown in studies to trigger a variety of signaling pathways in renal epithelial cells, as often it enhances the reabsorption of water, sodium, and chloride in the proximal tubule. [53] In general, it has been hypothesized that the cause of stone formation is a mismatch between urinary stone inhibitors and promoters.…”

Section: Renal Stones Inhibitors and Promotersmentioning

confidence: 99%

An insight on mechanism and management of kidney stones and its recurrence

Rajput,

Badwal,

Gupta

et al. 2023

Pharmaspire

View full text Add to dashboard Cite

Kidney stones (calculi) comprise mineral concretions which can form in both renal calyces and pelvis and can be free floating or associated with the renal papillae. It is an emerging urological condition that affects around 12% of the world’s population. Globally, the prevalence and recurrence of kidney stone disease are increasing, and there are limited effective treatment options. I manifest a brief general overview and then concentrate on risk factors, pathophysiology, and medical treatment of kidney stones. The major component of most stones is calcium oxalate, and many of them develop on a foundation of calcium phosphate known as Randall’s plaques, which are located on the renal papillary surface. The mechanism of stone formation is a complicated process that involves multiple physicochemical phenomena such as supersaturation, nucleation, growth, aggregation, and retention of urinary stone ingredients inside tubular cells. Cellular damage is also thought to enhance particle retention on renal papillary surfaces. There is currently no effective treatment or prevention for kidney stone recurrence. Recurrence prevention required behavioral and nutritional interventions, as significantly as pharmaceutical therapies tailored to the kind of stone. There is a great demand for recurrence prevention, which necessitates a deeper knowledge of the processes involved in the development of stones to design more effective medications. Open surgical lithotomy has given way to minimally invasive endourological procedures for the treatment of symptomatic kidney stones, resulting in lower patient morbidity, increased stone-free rates, and enhanced quality of life. As a result, furthering our knowledge of the biology of kidney stone development is a research focus for treating urolithiasis with novel medications.

show abstract

“…According to [16], variety of chemicals were preferred for induction of renal calculi in experimental animal through the exogenous administration of lithogenic material including sodium oxalate, glycolic acid, ethylene glycol (EG) and Hydroxyl-L-proline. The administration of the dose can be done by intra-peritoneal administration or by subcutaneous somatic minipump and also can be induced as miscible dose of toxicants with drinking water under oral administration method [17].…”

Section: Selection Of the Toxicantmentioning

confidence: 99%

Untitled

2019

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Multicellular organisms have special feature to concentrate and excrete nitrogenous wastes from the body. Normally kidneys in vertebrates have extensive role in the filtration and elimination function. Urinary calculi or stones are the most common cause for chronic / acute obstruction of urinary system. Pathologically urolithiasis (nephrolithiasis) relates with kidney stone disease. Understanding of the pathophysiology of nephrocytes with altered blood and urine constituents found to be thrust area of urolithiasis; therefore, present investigation has intended to focus on mechanism for development of calculus in kidney and phytoremideation against Ethylene glycol (EG) induced nephritic cells. With the intension vertebrate model rat have been used to understand pathogenesis and dose dependent recovery mechanism of two plant extract of Tribulus terrestris (Tt) and Amranthus cruentus (Ac). All animals were subjected to EG induction as a first part of experimental design. The recovery mechanism considering urine profile and histological observations were carried out with treatment of plant extracts. Observations in relations to doses compensation against EG were statically documented. Results of the different toxic concentration and exposure period were observed histologically and interpreted for comparative effects of plant extract (AC: TT) pertaining depleted percentage of crystal formation responsible for stone development. The overall mechanisms of phytoremideation were critically studied and interpreted in universally accepted vertebrate experimental model Rattus norvigicus.

show abstract

Metabolic assessment of recurrent and first renal calcium oxalate stone formers

Cited by 8 publications

References 19 publications

Kidney Stone Disease: An Update on Current Concepts

Kidney Stone Disease: An Update on Current Concepts

An insight on mechanism and management of kidney stones and its recurrence

Untitled

Contact Info

Product

Resources

About