Metabolic bone tissue disorders in patients with long bone fractures complicated by chronic osteomyelitis

Tsiskarashvili, Archil V.; Priorov, Moscow Orthopedics n.a. N.N.; Родионова, С. С.; Mironov, S P; Bukhtin, K.M.; Gorbatiuk, D.S.; Taraskin, A.Iu.

doi:10.18019/1028-4427-2019-25-2-149-155

Cited by 9 publications

(3 citation statements)

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“…In 2019, we published a retrospective study; the aim was to evaluate dynamics and values of markers and parameters of bone metabolism [16], which included 112 patients with infected pseudarthroses of long bones (humerus, femur, tibia) developing as an exacerbation of chronic osteomyelitis. The study had three main purposes:…”

Section: Our Experiencementioning

confidence: 99%

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Metabolic Disorders in Patients with Chronic Osteomyelitis: Etiology and Pathogenesis

Tsiskarashvili¹,

Zagorodniy²,

Родионова³

et al. 2021

Clinical Implementation of Bone Regeneration and Maintenance

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In this study, we discuss the peculiarities of metabolic disorders that follow the development of chronic osteomyelitis. For the purposes of this study, we analyzed the available data as well as results of our own clinical and scientific research. Chronic osteomyelitis leads not only to the destruction of bone tissue by pathogen but also to the shift of equilibrium between osteogenesis and bone resorption in the locus of bone infections. Such shift leads to additional damage not only to the bone cells (primarily osteoblasts) but also to the bone matrix. The final complications include difficulties with bone consolidation and prolongation of therapy, even when the patient is treated using an external fixation method like Ilizarov or similar techniques. Etiopathogenetic therapy, aimed at correction of metabolic disorders, allows to shorten the bone consolidation time (and respectively, the treatment time), preventing different pathogenetic processes that exacerbate and enhance each other’s effects. This study emphasizes the importance of etiopathogenetic therapy of metabolic disorders in patients with chronic osteomyelitis. Etiopathogenetic therapy should be combined with other necessary methods of the patient’s treatment, such as surgical debridement of the infection locus and antibiotic therapy.

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Section: Our Experiencementioning

confidence: 99%

“…Within this chapter, we made an attempt to synergize the knowledge in pathophysiology of the disorders described, as well as illustrate the importance of correction of impaired bone tissue metabolism using the results of our own work published in 2019 [16].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Disorders in Patients with Chronic Osteomyelitis: Etiology and Pathogenesis

Tsiskarashvili¹,

Zagorodniy²,

Родионова³

et al. 2021

Clinical Implementation of Bone Regeneration and Maintenance

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“…Це зумовлює зростання показників BSP. Кістковий сіалопротеїн присутній лише в зрілих остеобластах і не виявлений у їх попередниках, тому BSP є маркером пізнього диференціювання клітин кісток [45,46]. Abstract.…”

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Modern Aspects of Bone Tissue Reparative Regeneration and Analysis of Bone Metabolism Indices

Ryabenko¹,

Univercity²

2020

Ukr. ž. med. bìol. sportu

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Dynamics of bone tissue metabolism in the complex treatment of chronic posttraumatic osteomyelitis of long bones

Tsiskarashvili

Важаевич²,

Родионова

et al. 2020

N.N. Priorov Journal of Traumatology and Orthopedics

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Introduction: Chronic post-traumatic osteomyelitis is a complex problem of modern traumatology and orthopedics, affecting, in addition to medical, social and economic aspects of healthcare. When planning treatment, it is necessary to take into account the metabolic state of the bone tissue, since the effect of an infectious pathogen goes far beyond the classical lytic process, disrupting the balance of bone formation and bone resorption in various ways. The study is devoted to the study of the dynamics of parameters reflecting the metabolism of bone tissue in patients receiving complex therapy for chronic post-traumatic osteomyelitis of long bones. Aim: To study the dynamics of metabolic disorders of bone tissue in patients with orthopedic infection of long bones and large joints under conditions of ongoing complex etiotropic and compensatory therapy for 6 months, the timing of bone tissue consolidation within 2 years from the moment of surgery. Materials and methods: The study was prospective, observational, comparative, exploratory, involving 138 patients with post-traumatic chronic osteomyelitis of the long bones. Complex therapy included a combination of surgical treatment with antibacterial, anti-inflammatory therapy and drug correction of the revealed disorders of bone metabolism. The timing of the consolidation of bone defects after treatment and the dynamics of indicators of bone metabolism were studied. Results: The similarity of the periods of consolidation of different segments in the conditions of the described therapy was shown; the time period corresponding to the most pronounced dynamics of changes (correction) of violations was determined (3 months from the beginning of treatment); shows the effectiveness of metabolic therapy for the treatment of osteoarticular infections in various anatomical segments of the extremities. The results corresponds both to the results of the previous study and to the pathophysiological aspects of bone metabolism described in the literature. Conclusion: the timing of consolidation in the treatment of metabolic disorders is generally similar; the greatest changes in the parameters of bone metabolism are recorded within 3 months after the start of therapy. Also, the metabolic therapy regimen can be considered as universal for all segments.

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Metabolic bone tissue disorders in patients with long bone fractures complicated by chronic osteomyelitis

Cited by 9 publications

References 0 publications

Metabolic Disorders in Patients with Chronic Osteomyelitis: Etiology and Pathogenesis

Metabolic Disorders in Patients with Chronic Osteomyelitis: Etiology and Pathogenesis

Modern Aspects of Bone Tissue Reparative Regeneration and Analysis of Bone Metabolism Indices

Dynamics of bone tissue metabolism in the complex treatment of chronic posttraumatic osteomyelitis of long bones

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