Metabolic Cardioprotection: New Concepts in Implementation of Cardioprotective Effects of Meldonium

Даниленко, Л. М.; Klochkova, G.N.; Kizilova, Irina; Корокин, М. В.

doi:10.18413/2500-235x-2016-2-3-95-100

Cited by 7 publications

(9 citation statements)

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“…The obtained data confirm efficiency of the drug Detralex of 1000 mg for correction of function of an endothelium and restoration of the NO synthesizing function at experimental endothelial dysfunction that most likely it is bound to augmentation of the activity of antioxidatic enzymes, depression of influence of endothelin-1, and a factor of a necrosis of a tumor alpha. [5] Elongation of the rate of AT in an experiment at group of the animals receiving Detralex is caused by decrease of the phenomenon of a stasis, restoration of a linear blood flow, [6] and also immediate endotelioprotectiv action.…”

Section: Resultsmentioning

confidence: 99%

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Солдатов¹

2018

AJP

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Introduction: The phlebotropic effect of flavonoids is contradictory, and clinically significant effects are poorly understood theoretically. The efficiency of flavonoids needs verification by means of the large-scale experimental and clinical trials protected from the conflicts of interest. Research Tasks: Experimental study of venotonic, anti-aggregation and endothelioprotectiv properties of the drug Detralex 1000 mg. Materials and Methods: A venotonic effect was investigated after week administration of drug inside on model of the endoteliumdependent smooth muscle response to increased calcium ion isolated portal vein of rats. The Biopac Bas System Station installation including a polygraph of Biopac MP 150 with the TSD-104A module and the software of ACQ 4.2 was for this purpose used. The protective properties of the endothelium were studied on a 7-day model of L-N-nitro-L-arginine-methyl ether-induced rat endothelial dysfunction using invasive blood pressure recording. Aggregation of thrombocytes (AT) was investigated by a visual micromethod with use as inductors ADF, a collagen, thrombinum, ristomycinum, and adrenaline. Results: In model of endothelial dysfunction rising of sensitivity to the contractile response to Сa 2 + the isolated segment of a portal vein after use of the drug Detralex of 500 mg/kg per day, and also elongation of AT and decrease of coefficient of endothelial dysfunction on a background the course reception of the investigated preparation. Conclusion: Pleiotropic effect of micronized combination of diosmin and hesperidin, expressed in strengthening the contractile potential of smooth muscle veins, improving endothelial function, and lengthening thrombocyte aggregation, was сonfirmed.

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Section: Resultsmentioning

confidence: 99%

“…[2,3] At the same time, their studying has to be carried out on pharmacological targets, [4] in vivo and in vitro models. [5] Flavonoids -the most widespread group of the drugs which are applied at patients with a disease of peripheric veins. It is a group of biologically active substances derivative…”

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confidence: 99%

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Солдатов¹

2018

AJP

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“…Given that the fundamental role in the development of cardiotoxicity when using doxorubicin is connected with activation of lipid peroxidation of membrane structures and disruption of energy exchange, it is natural to use, as a metabolic cardioprotective therapy in patients with doxorubicin cardiomyopathy, substances that block the partial oxidation of free fatty acids and normalize the energy metabolism of cells exposed to hypoxia or ischemia. In particular, at the present stage, Meldonium is of great interest among metabolic drugs (Danilenko et al 2016;Ezhov et al 2018).…”

Section: Rationale For Choosing the Test Drugsmentioning

confidence: 99%

Evaluation of the effectiveness of pharmacotherapy for brain and heart diseases by monitoring the effects of drugs

Kharina¹,

Berezhnova²

2020

RRP

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Introduction: The study aims at analyzing the possibility of using a method of monitoring the action of drugs in real-time to assess the effectiveness of pharmacotherapy for brain and heart lesions. Materials and methods: To assess the effect of drugs in the experiment and in the clinic, the temperature difference between the biologically active point and the intact skin zone was recorded every second for 2 minutes. The work involved experimental and clinical parts. The experimental study was performed on 81 rabbits. In the experiment, the effect of Meldonium was evaluated when treating doxorubicin cardiomyopathy and the effect of Cortexin – when treating experimental brain ischemia. The clinical testing of the method involved 10 healthy volunteers and 20 patients of both sexes, diagnosed with acute cerebrovascular events of the ischemic-stroke type. Results and discussions: An increase of some indicators of differential thermometry of the biologically active point by 60% or more on the 7th day of the treatment concerning the values obtained before the treatment is indicative of a high probability of pronounced positive dynamics in the treatment of doxorubicin cardiomyopathy. If on the 7th day of the treatment, some indicators of differential thermometry of biologically active point С7 to exceed by 20% or more the similar indicators before the treatment, a high probability of pronounced positive dynamics in the treatment of ischemic stroke can be inferred. Conclusion: A safe, non-invasive method for monitoring the effects of drugs in real-time, which does not require any special training of a doctor, has been developed.

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“…At the same time, none of the proposed methods and their combinations provide guaranteed protection against ischemia-reperfusion injury, in connection with which the search and selection of innovative and promising compounds and preparations of this orientation continue. Preclinical studies at the systemic (Korokin et al, 2014;Peresypkina et al, 2016;Yakushev et al, 2016), cellular (Danilenko et al, 2016;Kravchenko et al, 2016;Kalmikov et al, 2018), and molecular (Bogus et al, 2018;Dzhimak et al, 2018;Soldativ et al, 2018) levels, including specific activity (Gumanova et al, 2007;Denisyuk et al, 2016;Danilenko, 2018) and toxicology studies (Kolesnichenko et al, 2018) in conjunction with bioequivalence studies )Kalmikov et al, 2018(, therapeutic equivalence and effectiveness (Avdeeva et al, 2016) are an integral part of the research of innovative drugs.…”

Section: Introductionmentioning

confidence: 99%

Incretin Mimetics Vildagliptin and Exenatide Improve Pedicle Skin Flap Survival in Rats.

Даниленко¹,

Tarasova²,

Pokrovskiy³

et al. 2019

jwpr

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Hypoxia and tissue ischemia are the leading factors in the alteration of tissues in many pathological conditions. Prevention and reversion of the effects of local ischemia, which develops during various surgical interventions, is an actual problem of modern medicine. The aim of the present study was to investigate the effect of exenatide and vildagliptin on the survival rate of an isolated pedicle skin flap in sixty adults Wistar rats. Simulation of a pedicle skin graft was performed on the second day of the experiment. After anesthesia under aseptic conditions, a skin graft was cut out: isolated in a plastic bag, the edges of the skin were stitched with interrupted sutures (nylon 3/0). Rats were divided into six groups: control group, exenatide group (10 µg/kg/day subcutaneously for nine days after surgery), vildagliptin group (0.2 mg/kg/day intraperitoneally for nine days after surgery) and pentoxifylline group (100 mg/kg/day intravenously, two hours before the surgical intervention). In the other two groups, glibenclamide (5 mg/kg) were administered before injection of incretin mimetics. On the third, seventh and tenth day, area of the surviving tissue was measured. Subsequently, the survival rate of the skin graft was calculated. The area of the surviving tissue in exenatide and vildagliptin group was 1.5 and 1.7 times more compared to the control group, respectively. Preliminary blockade of ATP-dependent potassium channels by glibenclamide eliminated the protective effect of exenatide and vildagliptin. The increase in the survival of ischemic tissues using exenatide and vildagliptin has been experimentally proved. The current study confirmed the important role of ATP-dependent potassium channels in dermatoprotective properties of incretin mimetics.

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Metabolic Cardioprotection: New Concepts in Implementation of Cardioprotective Effects of Meldonium

Cited by 7 publications

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Untitled

Untitled

Evaluation of the effectiveness of pharmacotherapy for brain and heart diseases by monitoring the effects of drugs

Incretin Mimetics Vildagliptin and Exenatide Improve Pedicle Skin Flap Survival in Rats.

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