Metabolic Ce:Roles of Zinc

Mills, Christopher; Quarterman, J.; Chesters, J. K.; Williams, Roger D.; Dalgarno, A.

doi:10.1093/ajcn/22.9.1240

Cited by 105 publications

(29 citation statements)

References 15 publications

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“…This reduction in feed intake was previously reported to be accompanied by a pattern of cyclic feeding in rats with Zn-deficient diet (Mills et al 1969;Chesters & Quarterman, 1970;Chesters & Will, 1973;Wallwork et al 1981;Gingliano & Millward, 1984;Kramer et al 1984;Quinn et al 1990). Here, we found by Cosinor analysis that the period of the cycle was 3.5 (SE 0.1) d. These results suggest that rats fed on Zn-deficient diet show little variation in feeding pattern, which consistently shows a cycle of 3.5 d.…”

Section: Discussionsupporting

confidence: 81%

“…Fig. 2a illustrates the cyclic feeding pattern of five Zn-deficient rats, which has been described by others (Mills et al 1969;Chesters & Quarterman, 1970;Wallwork et al 1981;Kramer et al 1984). The values of the rhythmometric parameters obtained by Cosinor analysis are shown in Table 2.…”

Section: R E S U L T Smentioning

confidence: 71%

“…Failure of growth during Zn deficiency in vivo is complex, with cyclical changes in feed intake (Mills et al 1969;Chesters & Quarterman, 1970;Chesters & Will, 1973;Wallwork et al 1981;Gingliano & Millward, 1984;Kramer et al 1%4;Quinn et al 1990), body weight (Wallwork et al 1981;Gingliano & Millward, 1984), and muscle mass (Gingliano & Millward, 1984). Zn deficiency impairs growth by a combination of decreased feed intake, lowered anabolic response to the feed, and increased catabolic response (Ginghano & Millward, 1984).…”

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confidence: 99%

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Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC3.5.2.2)

et al. 1995

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The body weight and feed intake of rats fed on a Zn-deficient diet for 28 d were reduced compared with those of control rats. The feed intakes of the Zn-deficient and control groups during the period were 10.2 (SE 0.3) and 15-7 (SE 0.2) g/d respectively. Cyclic variations in feed intake and body-weight changes were found in analysis not only of all the data for five rats but also that in each individual rat. Cosinor analysis revealed that the cyclical period of both the feed intake and body-weight change in the Zn-deficient rats was 3.5 (SE 0.1) d. The mesor and amplitude value of the feed intake in the Zn-deficient rats was 10.1 (SE 0.4) g/d and 3 5 (SE 0.5) g/d respectively, and that of body-weight change was 1.4 (SE 0.1) g/d and 7.9 (SE 1.3) g/d respectively. Among pyrimidine-catabolizing enzymes, dihydropyrimidinase (EC 3.5.2.2) activity showed significant retardation in the Zn-deficient rat liver with decrease of the enzyme protein.The ratio of apo-form to holo-form dihydropyrimidinase in the liver was not alfected by the Zndeficient diet.Zinc deficiency : Cosinor analysis : Dihydropyrimidinase

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Section: Discussionsupporting

confidence: 81%

Section: R E S U L T Smentioning

confidence: 71%

mentioning

confidence: 99%

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Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC3.5.2.2)

et al. 1995

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“…A role of Zn in polymeric organization of DNA and RNA molecules has been postulated also (Mills et al 1969; Prasad et al 1971). Zn stimulates the growth of cells through its effect exerted primarily on RNA synthesis (Wegner and Romano 1963).…”

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confidence: 95%

Serum Zn content in tumor-bearing rats treated with anticancer drugs.

Saito

Wakui

Himori

et al. 1979

Tohoku J. Exp. Med.

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“…It has also been proposed that metabolic hor mones such as insulin, somatotropin, insulin-like growth factor and corticosterone may be mediating factors in impaired growth (5,6). The reduction in feed intake is accompanied by cyclic patterns of feeding and body weight in rats given a Zn-deficient diet (3,4,(7)(8)(9)(10)(11)(12). Mills et al (7) proposed originally that rats fed a Zn-deficient diet develop a characteristic cyclic variation in feed intake, which has a frequency of 3.5-4 days.…”

mentioning

confidence: 99%