Metabolic Clearance of the Antioxidant Ascorbic Acid in Surgical Patients1

Rümelin, Andreas; Humbert, T.; Lühker, Olaf; Drescher, A.; Fauth, U.

doi:10.1016/j.jss.2005.03.017

Cited by 22 publications

(16 citation statements)

References 24 publications

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“…That low plasma concentrations reflect real deficiency and low intracellular concentrations is supported by the finding that urinary concentrations initially remain low despite high-dose intravenous supplementation, and only increase after a couple of days when plasma concentrations increase above 30 mmol/l [20,21]. This suggests that intracellular stores are replenished.…”

Section: Low Plasma Vitamin C Concentrationmentioning

confidence: 95%

Vitamin C supplementation in the critically ill patient

Berger

Straaten²

2015

Current Opinion in Clinical Nutrition and Metabolic Care

119

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Section: Low Plasma Vitamin C Concentrationmentioning

confidence: 95%

Vitamin C supplementation in the critically ill patient

Berger

Straaten²

2015

Current Opinion in Clinical Nutrition and Metabolic Care

119

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“…The average person, in good health, maintains normal plasma vitamin C levels with a daily intake of about 0.1 g/day. However, much higher doses, in the order of grams per day, are needed for critically ill patients to reach normal plasma vitamin C levels [2][3][4][5]. Without supplementation, plasma vitamin C levels are particularly low in critically ill patients [6][7][8][9][10], indicating that the body may have a greater need for vitamin C when under severe stress such as illness requiring intensive care.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

2020

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Background: Our recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin C effect on ventilation time, by the control group ventilation time (which we used as a proxy for severity of disease in the patients of each trial). Methods: We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials and reference lists of relevant publications. We included controlled trials in which the administration of vitamin C was the only difference between the study groups. We did not limit our search to randomized trials and did not require placebo control. We included all doses and all durations of vitamin C administration. One author extracted study characteristics and outcomes from the trial reports and entered the data in a spreadsheet. Both authors checked the data entered against the original reports. We used meta-regression to examine whether the vitamin C effect on ventilation time depends on the duration of ventilation in the control group.Results: We identified nine potentially eligible trials, eight of which were included in the meta-analysis. We pooled the results of the eight trials, including 685 patients in total, and found that vitamin C shortened the length of mechanical ventilation on average by 14% (P = 0.00001). However, there was significant heterogeneity in the effect of vitamin C between the trials. Heterogeneity was fully explained by the ventilation time in the untreated control group. Vitamin C was most beneficial for patients with the longest ventilation, corresponding to the most severely ill patients. In five trials including 471 patients requiring ventilation for over 10 h, a dosage of 1-6 g/day of vitamin C shortened ventilation time on average by 25% (P < 0.0001). Conclusions: We found strong evidence that vitamin C shortens the duration of mechanical ventilation, but the magnitude of the effect seems to depend on the duration of ventilation in the untreated control group. The level of baseline illness severity should be considered in further research. Different doses should be compared directly in future trials.

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“…It is also involved in neuronal regulation, providing an essential action within the brain, while also playing a major role in neuronal regulation (Smythies 1996(Smythies , 2000. The shortage of this vitamin in schizophrenic patients occurs as a metabolic response to the inflammatory aspects of the disease, increasing the clearance of AA and reducing plasma concentrations to undetectable levels in some cases (Rumelin et al 2005).…”

Section: Introductionmentioning

confidence: 99%

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

Damázio

Silveira

Canever

et al. 2017

An. Acad. Bras. Ciênc.

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Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the hyperlocomotion induced by ket. Ket also showed an increase of AChE activity within the prefrontal cortex and striatum prevented by AA. Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder.

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Metabolic Clearance of the Antioxidant Ascorbic Acid in Surgical Patients1

Cited by 22 publications

References 24 publications

Vitamin C supplementation in the critically ill patient

Vitamin C supplementation in the critically ill patient

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

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