Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis<sup>*</sup>

Young, J.W.; Shrago, Earl; Lardy, Henry A.

doi:10.1021/bi00899a015

Cited by 356 publications

(93 citation statements)

References 26 publications

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“…In the pig, malic enzyme, with glucose-6-phosphate dehydrogenase, is a major enzyme involved in supplying NADPH for the reductive biosynthesis of fatty acids (Young et al, 1964). Our results are in agreement with those obtained by Mourot et al (1994) showing the absence of a significant effect of diets rich in LA on pig muscle lipogenic enzyme activities.…”

Section: Dietary and Weight Effects On Activities Of Lipogenic Enzymesupporting

confidence: 91%

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Corino

Musella

Mourot

2008

Journal of Animal Science

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ABSTRACT:The Western diet is characterized by a high intake of SFA relative to PUFA, and the consumption of n-3 PUFA is decreased relative to n-6 PUFA. Therefore, there has been much interest in recent years in ways to manipulate the fatty acid composition of meat. The objective of this work was to determine the effects of dietary extruded linseed, an n-3 PUFA source, on growth performance, carcass composition, meat quality, and oxidative stability of pigs slaughtered at 111.0 (±4.8) kg of BW and 160.0 (±9.2) kg of BW. The association of these factors with BW at slaughter was also examined. Forty barrows, 78.1 (±1.75) kg of initial BW, were fed a control diet (2.5% sunflower oil) or a linseed diet containing 5% of whole extruded linseed. Both diets contained 170 mg of vitamin E and 250 μg of selenium. Eight pigs from each dietary treatment were slaughtered at 110 kg of BW and the others at 160 kg of BW. There was no dietary effect (P > 0.05) on growth, carcass characteristics, meat quality, or the activity of malic enzyme in LM and backfat. Inclusion of linseed increased (P < 0.05) n-3 PUFA content in both LM and backfat and decreased the n-6:n-3 PUFA ratio from 12 to 4.5 in LM, and from 11 to 3 in backfat. Liveweight at slaughter significantly influenced carcass characteristics, meat quality, total lipid and oxidative stability of LM, malic enzyme activity in adipose tissue, and fatty acid content of LM and backfat. This study shows that the inclusion of linseed in swine diets may improve the fatty acid profile of pork without deleteriously affecting oxidation or color stability. Thus, such a feeding practice may improve human health based on the n-6:n-3 PUFA ratio recommended for the human diet.

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Section: Dietary and Weight Effects On Activities Of Lipogenic Enzymesupporting

confidence: 91%

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Corino

Musella

Mourot

2008

Journal of Animal Science

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“…The co-enzyme NADPH is necessary for the biosynthesis of fatty acids and, in the pig, MENZ and G6PDH are recognised to be the main enzymes that supply NADPH [43]. Activities of both enzymes were lower in the fat tissues of our lactating sows than in growing pigs [26].…”

Section: Discussionmentioning

confidence: 73%

Influence of feed intake during pregnancy and lactation on fat body reserve mobilisation, plasma leptin and reproductive function of primiparous lactating sows

et al. 2001

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-From day 23 of pregnancy, 24 gilts received either a medium (M, n = 16) or a high (H, n = 8) level of feeding calculated to meet 115% or 190% of energy for maintenance, respectively. During lactation, all H sows were fed ad libitum (H-AL) whereas M sows were fed either ad libitum (M-AL, n = 8) or were restricted (M-RE, n = 8) to the amount of feed ingested by H-AL sows. Increased feed intake during pregnancy increased live weight, backfat thickness, and estimated body lipid and protein on days 4 and 25 of lactation (P < 0.05). It also resulted in lower feed intake and higher lipid mobilisation during lactation (P < 0.05) without a detrimental influence on milk production. Activities of malic enzyme and glucose-6-phosphate dehydrogenase from neck fat samples were higher in H than M sows on day 4 (P < 0.05). They decreased during lactation in H sows (P < 0.05). Mean diameter of adipocytes decreased during lactation in the 3 groups (P < 0.05) but did not differ between groups on days 4 and 25. Plasma leptin on days 4, 11, 18 and 25 was higher in H than in M sows (P < 0.05) but was not influenced by lactational feed intake. Neither measured characteristics of gonadotrophin secretion on day 22, nor of ovarian activity on day 26, were significantly influenced by the level of feeding during pregnancy or lactation.

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“…ACX activity in MS pigs presented a peak at 20 kg body weight and decreased thereafter in the four adipose tissues studied. ME and G6PDH are recognised to be the main enzymes involved in supplying NADPH for the reductive biosynthesis of fatty acids [36,37]. Malic enzyme activities were similar in muscles in each breed.…”

Section: Resultsmentioning

confidence: 94%

Development of intra- and intermuscular adipose tissue in growing Large White and Meishan pigs

Mourot¹,

Kouba²

1999

Reprod. Nutr. Dev.

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Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis^*

Cited by 356 publications

References 26 publications

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Influence of feed intake during pregnancy and lactation on fat body reserve mobilisation, plasma leptin and reproductive function of primiparous lactating sows

Development of intra- and intermuscular adipose tissue in growing Large White and Meishan pigs

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Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis*

Cited by 356 publications

References 26 publications

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Influence of extruded linseed on growth, carcass composition, and meat quality of slaughtered pigs at one hundred ten and one hundred sixty kilograms of liveweight1

Influence of feed intake during pregnancy and lactation on fat body reserve mobilisation, plasma leptin and reproductive function of primiparous lactating sows

Development of intra- and intermuscular adipose tissue in growing Large White and Meishan pigs

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Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis^*