1979
DOI: 10.1007/bf01872893
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Metabolic dependence of the offset of antidiuretic hormone-induced osmotic flow of water across the toad urinary bladder

Abstract: The elevated osmotic permeability to water induced by antidiuretic hormone (ADH) in the isolated urinary bladder of the toad is rapidly reversed by removal or washout of the ADH. This return to normal water permeability is delayed by the suppression of production of metabolic energy by any of three maneuvers: (i) low temperature (2 degrees C); (ii) inhibition of oxidative phosphorylation (10 mM azide or 0.5 mM 2,4 dinitrophenol); or (iii) inhibition of glycolysis (10 mM iodoacetate or 10 mM 2-deoxyglucose). Mo… Show more

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Cited by 13 publications
(5 citation statements)
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“…In each of thèse three situations, transepithelial water permeability remains elevated even if ADH is removed, probably as a resuit of inhibition of endocytosis (24). Indeed, as shown in Table 2, endocytosis of CF was almost totally blocked in each of thèse situations, and, perhaps correlatively, CF no longer inhibited water permeability (Fig.…”
Section: C734 Polycation Inhibition Of Adh-induced Water Flowmentioning
confidence: 83%
See 1 more Smart Citation
“…In each of thèse three situations, transepithelial water permeability remains elevated even if ADH is removed, probably as a resuit of inhibition of endocytosis (24). Indeed, as shown in Table 2, endocytosis of CF was almost totally blocked in each of thèse situations, and, perhaps correlatively, CF no longer inhibited water permeability (Fig.…”
Section: C734 Polycation Inhibition Of Adh-induced Water Flowmentioning
confidence: 83%
“…Prévention of endocytosis by metabolic inhibitors. Exposure of ADH-treated bladders to metabolic inhibitors prevents the return of water permeability when the hormone is withdrawn (24). One likely explanation of this phenomenon is that the endocytic retrieval of the water channel is prevented by thèse agents, which are known to inhibit endocytosis (34).…”
Section: Corrélation Between Cf-induced Endocytosis • and Inhibition mentioning
confidence: 99%
“…Our findings are also in agreement with the study of Masters et al . (24) who reported a lack of inhibitory effect by cytochalasin D on vasopressin‐activated water transport, but observed a sustained water transport after cytochalasin D‐washout. However, the latter group did not investigate this further.…”
Section: Discussionmentioning
confidence: 99%
“…The osmotic water flow response to antidiuretic hormone (ADH) or to cyclic adenosine 3',5' monophosphate (cAMP) was determined gravimetrically using the method of Bentley [2]. Paired hemibladders were mounted at the ends of glass cannules as detailed previously [14]. The rate of water flow across the hemibladders from a 1 : 10 diluted standard Ringer solution on the mucosal side to an undiluted aerated Ringer solution on the serosal side was determined before and after the addition of ADH (50 mU/ml, final serosal concentration) or of cAMP (10-aM, final serosal concentration).…”
Section: Methodsmentioning
confidence: 99%