Metabolic diseases and sex hormone levels affect differently in the development of cardiovascular and cerebrovascular diseases in elderly males

Gong, Yanping; Cheng, Xiaoling; Li, Chunlin; Li, Jian; Jin, Mei; Sun, Banruo; Tian, Hui

doi:10.3109/13685538.2014.1002082

Cited by 2 publications

(2 citation statements)

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“…This was indeed observed (Oskui et al ., ; Baillargeon et al ., ). Similarly, the risk of cerebrovascular disease was claimed to be related to an unbalanced oestradiol/testosterone ratio (Gong et al ., ).…”

Section: Testosterone Replacement Therapy and Cardiovascular Diseasementioning

confidence: 97%

The andrologist's contribution to a better life for ageing men: part 1

Comhaire

Mahmoud

2015

Andrologia

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The present opinion paper, explores the possibility that optimal hormone treatment and judicious nutraceutical food supplement can help ageing men to gain quality-adjusted life years. Testosterone treatment of patients with late-onset hypogonadism is given via the transdermal route or by intramuscular injections. There is overwhelming evidence that testosterone replacement therapy (TRT) has many beneficial effects and increases longevity by approximately 2% per year. On the basis of knowledge of physiology, animal and human experimental data, we explain why TRT reduces the risk of cardiovascular disease and of prostate cancer. However, the total testosterone load supplied per day should remain within the physiological range, and new galenical formulations should be developed, mimicking normal day-night variations.

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Section: Testosterone Replacement Therapy and Cardiovascular Diseasementioning

confidence: 97%

The andrologist's contribution to a better life for ageing men: part 1

Comhaire

Mahmoud

2015

Andrologia

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“…Cardiocerebral vascular diseases (CCVDs), including thrombosis, atherosclerosis, hypertension, cardiac hypertrophy, myocardial infarction, heart failure, stroke, and cerebral ischemia, are the major health problem all over the world, claiming more than 17.3 million lives annually [1][2][3]. Given the high incidence and high mortality of CCVDs, seeking feasible prevention and treatment strategy is highly imperative and critical to human health [4,5]. Western medicine is currently the mainstream medical treatment for CCVDs.…”

Section: Introductionmentioning

confidence: 99%

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui‐Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over the world, including atherosclerosis, hypertension, myocardial infarction, stroke, and so on. Chinese herbs pair of the Cinnamomum cassia Presl (Chinese name, rougui) and the Aconitum carmichaelii Debx (Chinese name, fuzi) can be effective in CCVDs, which is recorded in the ancient classic book Shennong Bencao Jing, Mingyibielu and Thousand Golden Prescriptions. However, the active ingredients and the molecular mechanisms of rougui-fuzi in treatment of CCVDs are still unclear. This study was designed to apply a system pharmacology approach to reveal the molecular mechanisms of the rougui-fuzi anti-CCVDs. The 163 candidate compounds were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). And 84 potential active compounds and the corresponding 42 targets were obtained from systematic model. The underlying mechanisms of the therapeutic effect for rougui-fuzi were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, component-target-disease (C-T-D) and target-pathway (T-P) networks were constructed to further dissect the core pathways, potential targets, and active compounds in treatment of CCVDs for rougui-fuzi. We also constituted protein-protein in interaction (PPI) network by the reflect target protein of the crucial pathways against CCVDs. As a result, 21 key compounds, 8 key targets, and 3 key pathways were obtained for rougui-fuzi. Afterwards, molecular docking was performed to validate the reliability of the interactions between some compounds and their corresponding targets. Finally, UPLC-Q-Exactive-MSE and GC-MS/MS were analyzed to detect the active ingredients of rougui-fuzi. Our results may provide a new approach to clarify the molecular mechanisms of Chinese herb pair in treatment with CCVDs at a systematic level.

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Metabolic diseases and sex hormone levels affect differently in the development of cardiovascular and cerebrovascular diseases in elderly males

Abstract: Metabolic diseases and sex hormones play different roles in the development of CAVD and CEVD, the methods for vascular protection in elderly men should be promoted differently according to the their risks of CAVD and CEVD.

Cited by 2 publications

References 19 publications

The andrologist's contribution to a better life for ageing men: part 1

The andrologist's contribution to a better life for ageing men: part 1

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui‐Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

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