Metabolic Disorders in Infertile Women With Polycystic Ovary Syndrome

Abstract

Introduction: Polycystic ovary syndrome (STD) is a common endocrine and metabolic disorder that affects significantly the general health of 6-18% of women. Data on metabolic disorders in PCOS is so far still limited and lack of uniformity in terms of race, geographic location, human-origin, age, sample size or lifestyle. Methodology: A cross-sectional description of 759 cases of reproductive-age women who were diagnosed with PCOS by Rotterdam criteria (391) and non-PCOS (368) visited 3 ART centers in central Vietnam including Hue University Hospital, Hue Central Hospital and Danang Hospital for Women and Children, from June 2016 to June 2017. Inclusion criteria to the control group consisted of infertile women without PCOS, regular menstrual cycle, no ovarian disease (ovary cyst/tumor or endometriosis), without history of ovarian surgery or determined ovarian failure. Clinical characteristics and basic hormonal profile, AMH, lipidemia variables, fasting blood glucose and glucose tolerance testing were performed to evaluate endocrine and metabolic status. Input and process data using SPSS 19.0 software. Results: The PCOS group had a 1.2-fold increase in overweight BMI (RR=1.20 with 95%CI: 1.02-1.42). The mean of waist circumference and waist / hip ratio was higher than that of control group. Lipidemia dysfunction was observed in 176 cases of PCOS (45%), of which total cholesterol abnormalities accounted for 21.0%, triglycerides 21.5%, LDL-C 25.6% and decreased HDL in 7.9%. Glycemia disturbances occurred in 119 cases (accounting for 30.4%) with abnormal blood glucose 16.4% and abnormal glucose tolerance test after 2 hours was 25.0%. Considering the metabolic factors, 68.8% of PCOS cases have at least one disorder. There is a correlation between metabolic disorders and clinical and endocrine factors: increased WHR with age, body mass index, AMH and prolactin; Total cholesterol associated with BMI and prolactin; Triglycerides related to age; HDL-C decrease is associated with BMI, LH and FSH; Hyperglycemia is associated with BMI. Conclusions: Endocrine disorders and especially metabolic syndrome are common in the infertile patients with PCOS in Central Vietnam. Appropriate screening strategy, early detection and timely intervention are needed to prevent systemic complications related to metabolic disorders. Key words: polycystic ovary syndrome, endocrine disorders, metabolic disorders