Metabolic disorders prevalence in sudden deafness

Abstract

OBJECTIVES:The aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys.INTRODUCTION:No consensus has been reached regarding the prevalence of metabolic disorders among sudden deafness patients or their influence as associated risk factors.METHODS:This cross‐sectional study enrolled all sudden deafness patients treated in the Otolaryngology Department of the University of São Paulo between January 1996 and December 2006. Patients were subjected to laboratory exams including glucose and cholesterol levels, low‐density lipoprotein cholesterol fraction, triglycerides, free T4 and TSH.RESULTS:The sample comprised 166 patients. We observed normal glucose levels in 101 (81.5%) patients and hyperglycemia in 23 (18.5%) patients, which is significantly different (p < 0.0001) compared to the diabetes mellitus prevalence (7.6%) in the Brazilian population. Cholesterol levels were normal in 78 patients (49.7%) and abnormal in 79 (50.3%) patients, which is significantly different compared to the Brazilian population (p = 0.0093). However, no differences were observed in low‐density lipoprotein cholesterol fraction (p = 0.1087) or triglyceride levels (p = 0.1474) between sudden hearing loss patients and the Brazilian population. Normal levels of thyroid hormones were observed in 116 patients (78.4%), and abnormal levels were observed in 32 (21.6%) patients. Compared with the prevalence of thyroid disorders in the general population (10%), statistical analysis revealed a significant difference (p = 0.0132) between these two groups.DISCUSSION:Among sudden deafness patients, we observed frequencies of hyperglycemia and thyroid disorders that were more than twice those of the general population.CONCLUSIONS:Hyperglycemia and thyroid disorders are much more frequent in patients with sudden deafness than in the general population and should be considered as important associated risk factors.

Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients

“…In a case-controlled study of 141 Italian patients, Aimoni et al (19) noted that the prevalence of diabetes was higher in the SSHL group (15.6%) compared with controls (8.5%, p = 0.03). Oiticica and Bittar (23) reported that hyperglycemia was noted in 23 (18.5%) Brazilian patients with SSHL ( p G 0.0001), a proportion that was higher than the national diabetic prevalence (7.6%). Lin et al (26) found that the prevalence of DM was higher in an SSHL group than in the controls (10.1 versus 4.3; p G 0.001).…”

Lipid Profile among Patients with Sudden Sensorineural Hearing Loss

“…cholesterol levels and hypertension, are more contributory as risk factors in its development. Moreover, Oiticica J and Bittar RSM [8] in studying the prevalence of metabolic disorders among patients with SSHL in Brazil noted that the mean age of their patients was 46.5 years and that 43.9 % were males were and 56.1 % were females.…”

“…Oiticica J, Bittar RSM [8] concluded that hyperglycemia and thyroid disorders are much more frequent in patients with sudden deafness than in the general population of Brazil and should be considered as important associated risk factors for sudden deafness. Furthermore, there was an increase on the prevalence of hypercholesterolemia in the sensorineural hearing loss SHL patient sample compared to the historical reference value for the Brazilian population, whereas, no difference was observed regarding LDL cholesterol fraction or triglyceride.…”

Eficácia da dieta fracionada e restritiva de carboidratos em pacientes portadores de distúrbios do equilíbrio corporal associados a alterações do metabolismo da glicose por meio da posturografia dinâmica computadorizada, disability

“…A dosagem metabólica que inclui glicemia, dosagem do colesterol total e frações, triglicérides e hormônios tireoidianos é de grande relevância e deve fazer parte da triagem de todos os pacientes com suspeita de disfunção da orelha interna (Charles et al, 1979;Pillsbury, 1981;Bittar et al, 1998;Oiticica;Bittar, 2010). A alta prevalência destes distúrbios, quando comparados a população geral, justifica sua solicitação para todos pacientes com tontura (Bittar et al, 2003).…”

“…Em relação ao gênero e à idade, os estudos apontam maior prevalência das alterações metabólicas relacionadas às disfunções da orelha interna em pacientes do gênero feminino com média de idade por volta da quinta década de vida (Pillsbury, 1981;Mangabeira-Albernaz;Fukuda, 1984;Ramos;Ramos, 1993;Bittar et al, 2003;Bittar et al, 2004;Fonseca;Davidson, 2006;Oiticica;Bittar, 2010). Provavelmente, alterações hormonais femininas, como as flutuações de estrogêneo e progesterona, associadas à migrânea e às disfunções de metabolismo de glicose favoreçam o aparecimento de distúrbios do equlíbrio corporal nesta faixa etária (Bittar et al, 2003;Sacco et al, 2012).…”