Metabolic effects of an enteral nutrition formula for diabetes: comparison with standard formulas in patients with type 1 diabetes

Crespillo, Marı́a del Carmen; Olveira, Gabriel; Adana, María Soledad Ruiz de; Rojo‐Martínez, Gemma; Garcı́a-Alemán, Jorge; Olvera, Pilar; Soriguer, Federico; Muñoz, Antonio Campos

doi:10.1016/s0261-5614(03)00047-5

Cited by 22 publications

(17 citation statements)

References 19 publications

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“…(61,73,74), the difference was reported to be statistically significant, while the remaining three studies (14,56,59) did not report any statistical analysis. However, these were not meta-analyzable due to incomplete data being reported (41,52,53) or incompatible data presentation (14,50) or study design (42).…”

Section: Other Outcomesmentioning

confidence: 94%

“…Although in the Nutritional support for diabetes (14,38,44,45,51,54). majority of the studies the diabetesspecific formulas showed lower triglyceride concentrations than the standard formulas, the combined data from four RCTs (14,38,44,45) indicated no significant effect (effect size Ϫ0.11 [95%CI Ϫ0.5 to 0.28], r ϭ 0; effect size Ϫ0.13 [Ϫ0.53 to 0.26], r ϭ 0.5) ( Table 1). Furthermore, two other long-term RCTs (49,54) reported no significant effect of diabetes-specific versus standard formulas on triglycerides, whereas the findings of a short-term RCT were unclear (48).…”

Section: Lipidemia (Total Cholesterol Hdl and Triglycerides)mentioning

confidence: 99%

“…Diabetes-specific formulas contain a defined nutrient composition designed to enable better glycemic control. Such nutrients include fructose (10), fiber (11), monounsaturated fatty acids (MUFAs) (12), soy protein (13,14), and antioxidants (15). Although general guidelines exist regarding the composition of the diet for those with diabetes (16 -18), there are no specific guidelines for patients with diabetes who are at risk of malnutrition, requiring nutritional support.…”

Section: Diabetes Care 28:2267-2279 2005mentioning

confidence: 99%

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Enteral Nutritional Support and Use of Diabetes-Specific Formulas for Patients With Diabetes

et al. 2005

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OBJECTIVE -The aim of this systematic review was to determine the benefits of nutritional support in patients with type 1 or type 2 diabetes.RESEARCH DESIGN AND METHODS -Studies utilizing an enteral nutritional support intervention (oral supplements or tube feeding) were identified using electronic databases and bibliography searches. Comparisons of interest were nutritional support versus routine care and standard versus diabetes-specific formulas (containing high proportions of monounsaturated fatty acids, fructose, and fiber). Outcomes of interest were measures of glycemia and lipid status, medication requirements, nutritional status, quality of life, complications, and mortality. Meta-analyses were performed where possible.RESULTS -A total of 23 studies (comprising 784 patients) of oral supplements (16 studies) and tube feeding (7 studies) were included in the review, and the majority compared diabetesspecific with standard formulas. Compared with standard formulas, diabetes-specific formulas significantly reduced postprandial rise in blood glucose (by 1.03 mmol/l [95% CI 0.58 -1.47]; six randomized controlled trials [RCTs]), peak blood glucose concentration (by 1.59 mmol/l [86 -2.32]; two RCTs), and glucose area under curve (by 7.96 mmol ⅐ l Ϫ1 ⅐ min Ϫ1 [2.25-13.66]; four RCTs, i.e., by 35%) with no significant effect on HDL, total cholesterol, or triglyceride concentrations. In addition, individual studies reported a reduced requirement for insulin (26 -71% lower) and fewer complications with diabetes-specific compared with standard nutritional formulas.CONCLUSIONS -This systematic review shows that short-and long-term use of diabetesspecific formulas as oral supplements and tube feeds are associated with improved glycemic control compared with standard formulas. If such nutritional support is given long term, this may have implications for reducing chronic complications of diabetes, such as cardiovascular events. Diabetes Care 28:2267-2279, 2005T he impact of better glycemic control on long-term clinical outcome is well recognized in both type 1 (1) and type 2 (2) diabetes, where hyperglycemia may result in life-threatening complications and numerous comorbidities. In addition, many conditions, including accidental injury, stroke, and critical illness, show a worse outcome in the presence of hyperglycemia (3).In the U.K., the costs associated with major hyperglycemic complications range from £872 (€1,256 or $1,607 for blindness in one eye) to £8,459 (€12,178 or $15,591 for amputation) per patient (4), and the U.S. has reported annual diabetes health care costs of $11,157 (€8,710) per patient (5). This large economic burden is unsurprising given that patients with diabetes are known to be admitted to the hospital more often than other patient groups, accounting for up to 25% of intensive care admissions (3,6). Many of these hospitalized patients will require nutritional support. In addition, an increasing number of patients receive long-term home enteral tube feeding (ETF), including those with diabetes (7...

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Section: Other Outcomesmentioning

confidence: 94%

Section: Lipidemia (Total Cholesterol Hdl and Triglycerides)mentioning

confidence: 99%

Section: Diabetes Care 28:2267-2279 2005mentioning

confidence: 99%

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Enteral Nutritional Support and Use of Diabetes-Specific Formulas for Patients With Diabetes

et al. 2005

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“…DSF tube feeds have been studied in T1DM patients and show similar reductions in postprandial glucose and insulin requirements in single bolus trials [34][35][36]. One longitudinal study demonstrates decreased postprandial glucose and lower insulin requirements over 2 weeks of observation [32].…”

Section: Enteral Nutrition In Diabetic Patientsmentioning

confidence: 96%

“…Two of the studies compared formulas with similar carbohydrate content, but differing amounts of fiber in patients with diabetes. del Carmen et al [34] showed no difference in blood glucose levels after a single bolus of standard or high-fiber formula in T1DM patients. Similarly, Thomas et al [28] demonstrated no difference in area under the curve for postprandial blood glucose after a single bolus of standard or high-fiber formula in T2DM patients.…”

Section: Enteral Nutrition In Diabetic Patientsmentioning

confidence: 98%

Inpatient Enteral and Parental Nutrition for Patients with Diabetes

Via

Mechanick

2010

Curr Diab Rep

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Both glycemic control and adequate nutrition support impact the clinical outcome of hospitalized patients. Providing nutrition to malnourished patients using the enteral or parenteral route may increase the risk of hyperglycemia, especially in patients with diabetes. Hyperglycemia can be managed through the use of enteral tube feeds with reduced carbohydrate content or limiting the carbohydrate concentration in parenteral formulas. Judicious use of insulin or other glucose-lowering medications synchronized with appropriate nutrition support allows for optimal inpatient glycemic control.

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Nutritional Support in Hospitalized Patients with Diabetes Mellitus

Chen¹,

Via²

2015

Glucose Intake and Utilization in Pre-Diabetes and Diabetes

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Metabolic effects of an enteral nutrition formula for diabetes: comparison with standard formulas in patients with type 1 diabetes

Cited by 22 publications

References 19 publications

Enteral Nutritional Support and Use of Diabetes-Specific Formulas for Patients With Diabetes

Enteral Nutritional Support and Use of Diabetes-Specific Formulas for Patients With Diabetes

Inpatient Enteral and Parental Nutrition for Patients with Diabetes

Nutritional Support in Hospitalized Patients with Diabetes Mellitus

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