Metabolic effects of salmon glucagon and glucagon-like peptide in coho and chinook salmon

Plisetskaya, Erika M.; Ottolenghi, C; Sheridan, Mark A.; Mommsen, Thomas P.; Gorbman, Aubrey

doi:10.1016/0016-6480(89)90093-2

Cited by 68 publications

(22 citation statements)

References 27 publications

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“…Plasma was immediately frozen and stored at -20°C until assayed. Insulin, glucagon and GLP were measured by homologous salmonid RIAs based on coho salmon purified pancreatic hormones and rabbit antisalmon pancreatic hormone serum as described by Plisetskaya et al (1985Plisetskaya et al ( , 1986aPlisetskaya et al ( , 1989 and Sundby el al. (1991).…”

Section: Methodsmentioning

confidence: 99%

Plasma insulin, glucagon, glucagon-like peptide and glucose levels in response to feeding, starvation and life long restricted feed ration in salmonids

Sundby¹,

Eliassen²,

Blom³

et al. 1991

Fish Physiol Biochem

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Plasma insulin, glucagon, glucagon-like peptide (GLP) and glucose were measured in samples taken from rainbow trout,Oncorhynchus mykiss. (1.5 years of age) before feeding and at selected times up to 9 days after feeding. The feed contained 21.7% carbohydrate (65% digestibe) in the dry matter. The fish responded to feeding with an elevated plasma insulin level (p<0.005) 0.5 h post-feeding, which may account for the unchanged plasma glucose levels. Twentyfour hours after feeding, plasma insulin level had returned to prefeeding levels, while 4-9 days after feeding, a significant reduction compared to pre-feeding levels was observed (p<0.001). During this period plasma glucose levels remained unchanged. The corresponding plasma glucagon or GLP levels showed no significant elevation in response to starvation, the plasma GLP concentration was even significantly reduced on days 4-9 post-feeding (p<0.01-0.001).Atlantic salmon,Salmo salar, (3.5 years of age) fed a calculated satiation ration (RL=100) throughout their lifetime had, in addition to a higher body weight, significantly higher plasma insulin (p<0.005) glucagon (p<0.0001) and GLP levels (p<0.0001) than fish fed half the satiation ration. The plasma glucose levels were, however, not significant different between the groups.

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Section: Methodsmentioning

confidence: 99%

Plasma insulin, glucagon, glucagon-like peptide and glucose levels in response to feeding, starvation and life long restricted feed ration in salmonids

Sundby¹,

Eliassen²,

Blom³

et al. 1991

Fish Physiol Biochem

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“…The glucagon gene encodes for several peptides that are expressed in different tissues (Nelson and Sheridan, 2006). Glucagon is lipolytic and stimulates hepatic TG lipase activity in rainbow trout and coho salmon (Harmon and Sheridan, 1992a;Plisetskaya et al 1989). Glucagon also stimulates TG lipase activity in adipocytes in sea bream and rainbow trout (Albalat et al 2005a;Albalat et al 2005b).…”

Section: Glucagonmentioning

confidence: 99%

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Leaver

Bautista

Björnsson

et al. 2008

Reviews in Fisheries Science

231

192

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Lipids are the predominant source of energy for fish. The mechanisms by which fish allocate energy from lipids, for metabolism, development, growth and reproduction are critical for understanding key life history strategies and transitions. Currently, the major lipid component in aquaculture diets is fish oil (FO), derived from wild capture fisheries that are exploited at their maximum sustainable limit. The increasing demand from aquaculture for FO will soon exceed supply and threaten the viability of aquaculture. Thus, it is essential to minimize FO use in aquaculture diets. This might be achieved by a greater understanding of lipid storage and muscle growth, or the identification of alternatives to FO in feeds. This review focuses on recent research applying molecular and genomic techniques to the study of fin-fish lipid metabolism from an aquaculture perspective. Accordingly, particular emphasis will be given to fatty acid metabolism and to highly unsaturated fatty acid (HUFA) biosynthesis, and to the transcriptional mechanisms and endocrine factors that regulate these processes in fish. Comparative studies of gene function and distribution are described which, when integrated with recent fish genome sequence information, provide insights into lipid homeostasis and the outcomes associated with the replacement of FO in fish diets.

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“…GLPs also differ from glucagon in their effect on glycogenolysis. In coho salmon in vivo and in liver slices, salmonid GLPs appear to exert much less of a glycogenolytic action than either salmon or mammalian glucagon ( [19] and Plisetskaya and Ottolenghi, unpublished). This observation supplies preliminary evidence that the preferred target for GLPs is indeed the gluconeogenic pathway.…”

Section: Discussionmentioning

confidence: 99%

Glucagon‐like peptides activate hepatic gluconeogenesis

1987

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Piscine (anglerfish, catfish, coho salmon) glucagon-like peptides (GLPs), applied at 3.5 nM, stimulate (1.1-1.9-fold) flux through gluconeogenesis above control levels in isolated trout and salmon hepatocytes. Human GLP-1 and GLP-2 also activate gluconeogenesis, but to a lesser degree than their piscine counterparts. Minor increases of substrate oxidation are noticed at times of peak gluconeogenic activation through GLPs. These hormones, which are derived from the same precursor peptide as glucagon are more potent activators of gluconeogenesis than glucagon when applied at equimolar concentrations, and do not appear to employ cAMP or cGMP as the intraceilular messenger in hepatic tissue.

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Metabolic effects of salmon glucagon and glucagon-like peptide in coho and chinook salmon

Cited by 68 publications

References 27 publications

Plasma insulin, glucagon, glucagon-like peptide and glucose levels in response to feeding, starvation and life long restricted feed ration in salmonids

Plasma insulin, glucagon, glucagon-like peptide and glucose levels in response to feeding, starvation and life long restricted feed ration in salmonids

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Glucagon‐like peptides activate hepatic gluconeogenesis

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