Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals

Lu, Dongping; Williams, Philip G.; Wang, Guangyi

doi:10.1002/9780470823163.ch12

Cited by 4 publications

(2 citation statements)

References 124 publications

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“…As edible plants used to have a long history of safe human consumption, this indicates low or no toxicity of phytochemicals on the human body system when used in optimum concentration. In modern days, almost one-third of approved drugs are natural products or their derivatives or synthetic products based on the natural model [1][2][3]. Though a large number of drugs come from natural sources, there is a lack of attention on natural compounds from the side of large pharmaceutical companies.…”

Section: Introductionmentioning

confidence: 99%

Natural products based nanoformulations for cancer treatment: current evolution in Indian research

et al. 2021

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The use of medicinal plants is as ancient as human civilization. The development of phytochemistry and pharmacology facilitates the identification of natural bioactive compounds and their mechanisms of action, including against cancer. The efficacy and the safety of a bioactive compound depend on its optimal delivery to the target site. Most natural bioactive compounds (phenols, flavonoids, tannins, etc) are unable to reach their target sites due to their low water solubility, less cellular absorption, and high molecular weight, leading to their failure into clinical translation. Therefore, many scientific studies are going on to overcome the drawbacks of natural products for clinical applications. Several studies in India, as well as worldwide, have proposed the development of natural products-based nanoformulations to increase their efficacy and safety profile for cancer therapy by improving the delivery of natural bioactive compounds to their target site. Therefore, we are trying to discuss the development of natural products-based nanoformulations in India to improve the efficacy and safety of natural bioactive compounds against cancer.

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Section: Introductionmentioning

confidence: 99%

Natural products based nanoformulations for cancer treatment: current evolution in Indian research

et al. 2021

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“…Today, approximately one-third of the top-selling pharmaceuticals are natural products or their derivatives. [1][2][3] Although many of the drugs used today come from natural products, major pharmaceutical companies have not paid due attention to these compounds for a variety of reasons. The lack of attention could be due to the outdated idea that natural products are only useful as antibiotics: natural products had huge success in the post-World War II era as antibiotics, and the two terms have become synonymous.…”

Section: Introductionmentioning

confidence: 99%

Natural product-based nanomedicine: recent advances and issues

Watkins¹,

Wu²,

Zhang³

et al. 2015

IJN

164

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Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications.

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Total Synthesis of (+)-Roxaticin via C−C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction

et al. 2010

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A total synthesis of the oxo-polyene macrolide (+)-roxaticin is achieved in 20 steps from 1,3-propanediol. In this approach, nine of ten C-C bonds formed in the longest linear sequence are made via metal catalysis, including 7 C-C bonds formed via iridium catalyzed alcohol C-C coupling. Notably, the present synthesis, which represents the most concise preparation of any oxo-polyene macrolide reported to date, is achieved in the absence of chiral reagents, chiral auxiliaries with minimal use of premetallated C-nucleophiles.

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Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals

Cited by 4 publications

References 124 publications

Natural products based nanoformulations for cancer treatment: current evolution in Indian research

Natural products based nanoformulations for cancer treatment: current evolution in Indian research

Natural product-based nanomedicine: recent advances and issues

Total Synthesis of (+)-Roxaticin via C−C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction

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